Plantagiolides K–N, three new withanolides and one withanolide glucoside from Tacca plantaginea

Natural withanolides, an update

“…38 Phytochemical investigation of the whole plants of Tacca plantaginea led to the isolation of plantagiolide M ( 178 ) and its glucoside, plantagiolide N ( 179 ), the first withanolide glycoside featuring a glucose located at C-7. 92…”

“…38 Phytochemical investigation of the whole plants of Tacca plantaginea led to the isolation of plantagiolide M (178) and its glucoside, plantagiolide N (179), the rst withanolide glycoside featuring a glucose located at C-7. 92 Phytochemical investigation of Physalis pubescens L. by our group led to the isolation of three new withanolides (180)(181)(182) and four new withanolide glucosides (183)(184)(185)(186). The absolute conguration of physapubside B (184) was assigned using X-ray crystallography, and the absolute conguration of the 24,25-diol moiety in physapubescin E (180) was determined using the in situ dimolybdenum electronic circular dichroism method.…”

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

“…Four new withanolides, including one having a sugar moiety, called plantagiolides, were isolated from Tacca plantaginea . These new withanolides were evaluated for their TNFα-induced NF-κB transcriptional and cytotoxic activities [ 98 ]. The evaluation of the TNFα-induced NF-κB transcriptional activity of compounds 87 – 90 ( Figure 11 ) in human embryonic kidney cells (HEK293T) cells using an NF-κB-luciferase assay showed the new compounds to be inactive, with IC 50 values greater than 20 μM.…”

Untiring Researches for Alternative Resources of Rhizoma Paridis

“…In order to discuss/explore whether the Tacca species possess the same steroidal constituents as that of RP, our group investigated the phytochemicals of two Tacca species ( T. plantaginea and T. subflabellata ). The results led to the structural characterization of eight new spirostane saponins, named taccaosides E–L ( 92 – 99 ) [ 53 ], taccaoside C ( 100 ) [ 54 ], taccasubosides B ( 103 ) and C ( 104 ) [ 55 ], three furostanol saponins, named taccaoside D ( 101 ) [ 54 ], taccaosides A ( 106 ) and B ( 107 ) [ 56 ], a new C 21 steroidal saponin, taccasuboside D ( 105 ) [ 55 ], and 13 new withanolides, named taccasuboside A ( 102 ) [ 55 ], plantagiolides A–E ( 108 – 112 ) [ 57 ], plantagiolide F ( 113 ) [ 58 ], plantagiolides K–N ( 114 – 117 ) [ 59 ], and taccalonolides W–Y ( 118 – 120 ) [ 60 ] (Fig. 4 ; Table 4 ).…”