Plant virus-based materials for biomedical applications: Trends and prospects

Eiben, Sabine; Koch, Claudia; Altintoprak, Klara; Southan, Alexander; Tovar, Günter E. M.; Laschat, Sabine; Weiss, Ingrid M.; Wege, Christina

doi:10.1016/j.addr.2018.08.011

Cited by 82 publications

(79 citation statements)

References 284 publications

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“…It should be added here, however, that in parallel to the RNA‐stabilized nanorings with superior pH stability and dispersal, also a number of engineered TMV CP types have been developed that allow the fabrication of similarly robust disks devoid of RNA, due to enhanced CP‐CP interactions (Bruckman et al, ; Dedeo et al, ; Finbloom et al, ; J. Zhang, Wang, Zhou, Chen, & Wang, ; J. Zhang, Zhou, & Wang, ; Zhou, Li, Dai, Meng, & Wang, ). Although several of them show an increased propensity for aggregation under certain conditions, they reflect the high interest in such bionanostructures for various further purposes, including vaccination, delivery of biopharmaceuticals and intravital imaging and nuclear magnetic resonance contrast agents, plasmonics and energy transfer (see Altintoprak et al, for an overview and Eiben et al, and the above references for details on the applications).…”

Section: Tmv‐like Particles Of Modified Length and Aspect Ratiomentioning

confidence: 99%

“…Lanes (1) and (2) show TMV WT and TMV Lys particles isolated from tobacco, respectively. Reprinted from Eiben et al () with permission from Springer…”

Section: Fine‐tunable Mixtures Of Distinct Cp Speciesmentioning

confidence: 99%

“…Supramolecular protein structures comprise numerous different assemblies with shapes determined by the own natural or engineered protein constituents, or—alternatively—by organic or inorganic nonprotein cargo and linkers. Such protein‐based structures include, among others, apoferritin (Calò, Eiben, Okuda, & Bittner, ), clathrin (Krajina, Proctor, Schoen, Spakowitz, & Heilshorn, ), cellular microcompartments (Plegaria & Kerfeld, ), or virus‐like particle (VLP)‐based nanocages and elongated scaffolds (e.g., Aumiller, Uchida, & Douglas, ; Chen et al, ; Dragnea, ; Eiben et al, ; Koch et al, ; L. Wang et al, ; Wege & Lomonossoff, ; see more references in 1.3). Extensive 2D lattices may form for example, from bacterial surface‐(S‐)‐layer proteins (SLPs) (Farjadian et al, ; Ilk, Egelseer, & Sleytr, ), and elongated fibers from synthetic or natural peptides, proteins like collagen, keratin or silk fibroins, and protein domains (Aigner, DeSimone, & Scheibel, ; Luo et al, ; Pieters, van Eldijk, Nolte, & Mecinović, ).…”

Section: Introductionmentioning

confidence: 99%

“…Hence, plant viruses have developed into one of the major classes of biological carrier templates so that all of their features described up to here have been reviewed extensively and repeatedly. For a more complete survey on looming plant VNP applications, the reader is referred to book chapters and articles that list appropriate original references, and specific recent reviews (e.g., Aljabali et al, ; Chu, Brown, Culver, & Ghodssi, ; Culver et al, ; Czapar & Steinmetz, ; Eiben et al, ; Fan et al, ; Koch et al, ; Lam & Steinmetz, ; K. L. Lee et al, ; Lomonossoff, ; Mao, Liu, & Cao, ; Steele et al, ; van Rijn & Schirhagl, ; Wege & Lomonossoff, ; Wen et al, ; Wen & Steinmetz, ). Instructive details on numerous of the underlying preparation and application procedures may be retrieved for example, from Khudyakov and Pumpens (); Lin and Ratna (); Steinmetz and Manchester (); Wege and Lomonossoff ().…”

Section: Introductionmentioning

confidence: 99%

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From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Wege

Koch

2019

WIREs Nanomed Nanobiotechnol

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The self‐assembly of viral building blocks bears exciting prospects for fabricating new types of bionanoparticles with multivalent protein shells. These enable a spatially controlled immobilization of functionalities at highest surface densities—an increasing demand worldwide for applications from vaccination to tissue engineering, biocatalysis, and sensing. Certain plant viruses hold particular promise because they are sustainably available, biodegradable, nonpathogenic for mammals, and amenable to in vitro self‐organization of virus‐like particles. This offers great opportunities for their redesign into novel “green” carrier systems by spatial and structural synthetic biology approaches, as worked out here for the robust nanotubular tobacco mosaic virus (TMV) as prime example. Natural TMV of 300 x 18 nm is built from more than 2,100 identical coat proteins (CPs) helically arranged around a 6,395 nucleotides ssRNA. In vitro, TMV‐like particles (TLPs) may self‐assemble also from modified CPs and RNAs if the latter contain an Origin of Assembly structure, which initiates a bidirectional encapsidation. By way of tailored RNA, the process can be reprogrammed to yield uncommon shapes such as branched nanoobjects. The nonsymmetric mechanism also proceeds on 3'‐terminally immobilized RNA and can integrate distinct CP types in blends or serially. Other emerging plant virus‐deduced systems include the usually isometric cowpea chlorotic mottle virus (CCMV) with further strikingly altered structures up to “cherrybombs” with protruding nucleic acids. Cartoon strips and pictorial descriptions of major RNA‐based strategies induct the reader into a rare field of nanoconstruction that can give rise to utile soft‐matter architectures for complex tasks. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures

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Section: Tmv‐like Particles Of Modified Length and Aspect Ratiomentioning

confidence: 99%

“…Lanes (1) and (2) show TMV WT and TMV Lys particles isolated from tobacco, respectively. Reprinted from Eiben et al () with permission from Springer…”

Section: Fine‐tunable Mixtures Of Distinct Cp Speciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Wege

Koch

2019

WIREs Nanomed Nanobiotechnol

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“…The increasing interest and recent publications stimulated us to summarize and discuss the latest developments in the design of vaccines based on plant viruses. Descriptions of other plant VLP applications can be found in several recent review articles [34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Use of Plant Virus-Like Particles as Vaccines

Baļķe

Zeltiņš

2020

Viruses

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Vaccination is one of the most effective public health interventions of the 20th century. All vaccines can be classified into different types, such as vaccines against infectious diseases, anticancer vaccines and vaccines against autoimmune diseases. In recent decades, recombinant technologies have enabled the design of experimental vaccines against a wide range of diseases using plant viruses and virus-like particles as central elements to stimulate protective and long-lasting immune responses. The analysis of recent publications shows that at least 97 experimental vaccines have been constructed based on plant viruses, including 71 vaccines against infectious agents, 16 anticancer vaccines and 10 therapeutic vaccines against autoimmune disorders. Several plant viruses have already been used for the development of vaccine platforms and have been tested in human and veterinary studies, suggesting that plant virus-based vaccines will be introduced into clinical and veterinary practice in the near future.

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Flexuous Plant Viruses as Nanomaterials for Biomedical Applications

De¹

2022

Nanomaterials in Clinical Therapeutics

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Plant virus-based materials for biomedical applications: Trends and prospects

Cited by 82 publications

References 284 publications

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Recent Advances in the Use of Plant Virus-Like Particles as Vaccines

Flexuous Plant Viruses as Nanomaterials for Biomedical Applications

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