Plant Sterols and Risk of Stomach Cancer: A Case-Control Study in Uruguay

Stéfani, Eduardo De; Boffetta, Paolo; Ronco, Álvaro L.; Brennan, Paul; Deneo‐Pellegrini, Hugo; Carzoglio, Julio; Mendilaharsu, Marı́a

doi:10.1207/s15327914nc372_4

Cited by 123 publications

(66 citation statements)

References 18 publications

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“…Only two epidemiological studies on plant sterols and cancer have been performed. In the first study, Mendilaharsu and colleagues (30) reported a protective effect of phytosterols in lung cancer, whereas a similar effect was observed in gastric cancer (31). It has been suggested that plant sterols could induce decreased cell growth and apoptosis through ceramide production (32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay

Stéfani¹,

Brennan²,

Boffetta³

et al. 2000

Nutrition and Cancer

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Section: Discussionmentioning

confidence: 99%

Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay

Stéfani¹,

Brennan²,

Boffetta³

et al. 2000

Nutrition and Cancer

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“…inverse association between consumption of vegetables and fruits and risk of human cancers at many sites (8)(9)(10).…”

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confidence: 99%

The Chemopreventive Bioflavonoid Apigenin Inhibits Prostate Cancer Cell Motility through the Focal Adhesion Kinase/Src Signaling Mechanism

Franzen

Amargo

Todorović

et al. 2009

Cancer Prevention Research

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Prostate cancer mortality is primarily attributed to metastatic rather than primary, organ-confined disease. Acquiring a motile and invasive phenotype is an important step in development of tumors and ultimately metastasis. This step involves remodeling of the extracellular matrix and of cell-matrix interactions, cell movement mediated by the actin cytoskeleton, and activation of focal adhesion kinase (FAK)/Src signaling. Epidemiologic studies suggest that the metastatic behavior of prostate cancer may be an ideal target for chemoprevention. The natural flavone apigenin is known to have chemopreventive properties against many cancers, including prostate cancer. Here, we study the effect of apigenin on motility, invasion, and its mechanism of action in metastatic prostate carcinoma cells (PC3-M). We found that apigenin inhibits PC3-M cell motility in a scratchwound assay. Live cell imaging studies show that apigenin diminishes the speed and affects directionality of cell motion. Alterations in the cytoskeleton are consistent with impaired cell movement in apigenin-treated cells. Apigenin treatment leads to formation of "exaggerated filopodia," which show accumulation of focal adhesion proteins at their tips. Furthermore, apigenin-treated cells adhere more strongly to the extracellular matrix. Additionally, apigenin decreases activation of FAK and Src, and phosphorylation of Src substrates FAK Y576/577 and Y925. Expression of constitutively active Src blunts the effect of apigenin on cell motility and cytoskeleton remodeling. These results show that apigenin inhibits motility and invasion of prostate carcinoma cells, disrupts actin cytoskeleton organization, and inhibits FAK/Src signaling. These studies provide mechanistic insight into developing novel strategies for inhibiting prostate cancer cell motility and invasiveness.Prostate cancer is the most common noncutaneous malignancy in American males (over 186,000 cases diagnosed yearly), and the second leading cause of cancer-related deaths in American men (28,660 estimated deaths in 2008; ref. 1). In prostate cancer, most deaths are attributed to metastatic disease rather than primary, organ-confined prostate cancer (2-5). Numerous epidemiologic studies (6) suggest that the metastatic behavior of prostate cancer may be an ideal target for pharmacologic intervention with chemopreventive agents. Because prostate cancer is typically diagnosed in older men, chemopreventive and/or chemotherapeutic strategies to delay its progression may have a substantial impact on clinical outcome. Epidemiologic studies have shown that Asian men experience a lower incidence of metastatic prostate cancer than Western men, which is attributed to dietary and/or life-style factors (3, 4). Interestingly, some studies suggest that the incidence of primary cancer may be similar in Asian and Western populations, and that the higher rate of prostate cancer-related deaths in the United States is due to a higher rate of prostate cancer metastasis (3,5).Apigenin (4′, 5, 7-trihydroxyflavo...

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“…Phytosterols were also found to be protective to ulcers [104] and to have antifungal activity [105]. The intake of phytosterols is beneficial to prevent or treat many different types of cancer, inlcuding breast [106], prostate [107 -108], lung [109], esophagus [110], stomach [111], endometrial [112], and ovary [113].…”

Section: Overview Of the Phospholipids Composition Of Nigerian Vegetamentioning

confidence: 99%

Dietary Phospholipids and Phytostrerols: A Review on Some Nigerian Vegetable Oils

Aremu¹,

Ibrahim²

2017

ijSciences

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Dietary phospholipids and phytosterols have proven to be potential sources of bioactive lipids with widespread effects on pathways related to inflammation, cholesterol metabolism, and high-density lipoprotein function. Due to their biological and physicochemical properties, they are important in human nutrition. The efficient separation and accurate quantification of phospholipids and phytosterols can be achieved with highperformance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) and gas chromatography (GC) often combined with mass spectrometry respectively. The phospholipid and phytosterol compositions of some Nigerian vegetable oils were reviewed. From the literature, the phospholipid concentrations (mg/100) of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, lysophosphatidyl choline, phosphatidyl inositol and phosphatidic acid are in the range of 2.60 -1168.00, 1.13 -558.00, 0.10 -336.00, 0.

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Plant Sterols and Risk of Stomach Cancer: A Case-Control Study in Uruguay

Cited by 123 publications

References 18 publications

Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay

Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay

The Chemopreventive Bioflavonoid Apigenin Inhibits Prostate Cancer Cell Motility through the Focal Adhesion Kinase/Src Signaling Mechanism

Dietary Phospholipids and Phytostrerols: A Review on Some Nigerian Vegetable Oils

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