Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol

Seppo, L; Jauhiainen, T.; Nevala, Riikka; Poussa, Tuija; Korpela, Riitta

doi:10.1007/s00394-006-0639-2

Cited by 39 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the effects of 3-supplemented milk (250 ml/day) relate to plasma TGL and VLDLc, both changing in a similar range, without affecting plasma LDLc levels. The lowering of 9.8% in plasma LDLc, induced by the PhyS-milk, is in the range reported in previous plant sterol supplementation trials with once-a-day intake design ( 36,37 ). It is to be noted that the effect of the PhyS-supplemented milk in our study was observed with a daily dose of 1.57 g/day, which was not consumed with the main meals.…”

Section: Discussionsupporting

confidence: 82%

Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk

Padró

Vilahur

Sánchez-Hernández

et al. 2015

Journal of Lipid Research

View full text Add to dashboard Cite

The prevalence of overweight and obesity is increasing and represents a primary health concern due to the relationship between obesity and a number of diseases and comorbidities including hyperlipidemia, a major risk factor for atherosclerosis and CVD. Dyslipidemias, typically characterized by high serum LDL cholesterol (LDLc), or low levels of HDL cholesterol (HDLc), and/or elevated triglyceride (TGL) levels, are common among patients with established CVD, type 2 diabetes mellitus, and the metabolic syndrome ( 1 ).Because cholesterol lowering is a major target for reducing CVD risk ( 2 ), dietary interventions to reduce LDLc levels in individuals with borderline dyslipidemia and obesity without overall cardiovascular risk are becoming mandatory. Cholesterol concentrations within the circulatory pool are products of input from gut absorption and endogenous synthesis relative to clearance through Abstract The benefi ts of dietary phytosterols (PhySs) and long-chain n-3 PUFA ( 3) have been linked to their effects as cholesterol-and triglyceride (TGL)-lowering agents. However, it remains unknown whether these compounds have further metabolic effects on LDL lipid composition. Here, we studied the effects of PhyS-or 3-supplemented low-fat milk (milk) on the LDL-lipidome. Overweight and moderately hypercholesterolemic subjects (n = 32) were enrolled in a two-arm longitudinal crossover study. Milk (250 ml/day), enriched with either 1.57 g PhyS or 375 mg 3 (EPA + DHA), was given to the participants during two sequential 28 day intervention periods. Compared with baseline, PhyS-milk induced a higher reduction in the LDL cholesterol (LDLc) level than 3-milk. LDL resistance to oxidation was signifi cantly increased after intervention with PhyS-milk. Changes in TGL and VLDL cholesterol were only evident after 3-milk intake. Lipidomic analysis revealed a differential effect of the PhyS-and 3-milk interventions on the LDL lipid metabolite pattern. Content in LDL-glycerophospholipids was reduced after PhySmilk intake, with major changes in phosphatidylcholine (PC) and phosphatidylserine subclasses, whereas 3-milk induced signifi cant changes in the long-chain polyunsaturated cholesteryl esters and in the ratio PC36:5/lysoPC16:0, associated to a reduced infl ammatory activity. In conclusion, daily intake of milk products containing PhyS or 3 supplements induce changes in the LDL-lipidome that indicate reduced infl ammatory and atherogenic effects, beyond their LDLc-and TGL-lowering effects. -Padro, T., G. Vilahur, J. S á nchez-Hern á ndez, M. Hern á ndez, R. M. Antonijoan, A. Perez, and L. Badimon. Lipidomic changes of LDL in overweight and moderately hypercholesterolemic

show abstract

Section: Discussionsupporting

confidence: 82%

Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk

Padró

Vilahur

Sánchez-Hernández

et al. 2015

Journal of Lipid Research

View full text Add to dashboard Cite

show abstract

“…This finding was in agreement with studies in which the TMD has been applied (17). Yogurt and other milk products have been studied in the literature in the context of serum lipid lowering.…”

Section: Discussionsupporting

confidence: 91%

“…Yogurt and other milk products have been studied in the literature in the context of serum lipid lowering. It has been shown that low-fat milk products enriched with plant stanol esters lower both total cholesterol and LDL cholesterol significantly in subjects with mild or moderate hypercholesterolemia (17). In another study, the consumption of one yogurt serving per day containing 2 g of stanol significantly reduced cholesterol levels; this effect was not observed with placebo (18).…”

Section: Discussionmentioning

confidence: 99%

Effects of a Stanol-Enriched Yogurt on Plasma Cholesterol Levels

Furuncuoglu¹,

Başar²,

Alıcı³

et al. 2014

Electron J Gen Med

View full text Add to dashboard Cite

show abstract

“…The cholesterol-lowering action of PS is thought to occur, at least in part, through competition with dietary and biliary cholesterol for intestinal absorption in mixed micelle (Calpe-Berdiel et al, 2009). The daily consumption of foods rich in PS has been shown to reduce the plasma concentration of LDLc by 10% (Katan et al, 2003) without altering levels of high-density lipoprotein cholesterol (HDLc) or triacylglycerols (TAG) (Noakes et al, 2005;Seppo et al, 2007). PS in their free form are slightly soluble in fats; in fact, their solubility and hypolipidemic effects can be increased by esterification.…”

Section: Introductionmentioning

confidence: 99%

“…Most previous studies have shown that the dispersion of PS in different food forms substantially affects the extent to which levels of LDLc are reduced (Katan et al, 2003). However, few studies have examined the hypocholesterolemic effect of PS supplementation via low-fat dairy beverages in the absence of lipidlowering medication (Noakes et al, 2005;Seppo et al, 2007;Bañuls et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by apolipoprotein E polymorphism or diameter of low-density lipoprotein particles

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: The importance of both low-density lipoprotein cholesterol (LDLc) size and the apolipoprotein E (Apo E) in the atherogenic process is known, but there is little information with regard to the effect of phytosterols (PS) on these parameters. The aim of this study was to evaluate the influence of PS on lipid profile and LDLc size according to Apo E genotype. Subjects/Methods: This was a randomized parallel trial employing 75 mild-hypercholesterolemic subjects and consisting of two 3-month intervention phases. After 3 months of receiving a standard healthy diet, subjects were divided into two intervention groups: a diet group (n ¼ 34) and a diet þ PS group (n ¼ 41) that received 2 g/day of PS. Total cholesterol (TC), triacylglycerols, LDLc, high-density lipoprotein cholesterol (HDLc), non-HDLc, Apo A-I and B-100, LDLc size and Apo E genotype were determined. Results: Patients receiving PS exhibited a significant decrease in TC (5.1%), LDLc (8.1%), non-HDLc (7.4%) and Apo B-100/Apo A-I ratio (7.7%), but these effects did not depend on Apo E genotype. No significant changes were found in lipid profile according to Apo E genotype when patients following dietary recommendations were considered as a whole population or separately. No variations in LDLc size were observed in any of the intervention groups. Conclusion:The results of this study show that Apo E genotype does not have an impact on the lipid response to PS as a cholesterol-lowering agent in mild-hypercholesterolemic patients. Furthermore, the evidence obtained confirms that LDLc particle size is not modified when PS are added to a standard healthy diet.

show abstract

Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol

Abstract: These results imply that low-fat milk products enriched with plant stanol esters lower both total cholesterol and LDL cholesterol statistically significantly in subjects with mild or moderate hypercholesterolemia. The changes tended to relate to the baseline LDL-cholesterol concentration.

Cited by 39 publications

References 32 publications

Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk

Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk

Effects of a Stanol-Enriched Yogurt on Plasma Cholesterol Levels

Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by apolipoprotein E polymorphism or diameter of low-density lipoprotein particles

Contact Info

Product

Resources

About