Plant selenium toxicity: Proteome in the crosshairs

Kolbert, Zsuzsanna; Molnár, Árpád; Feigl, Gábor; Hoewyk, Doug Van

doi:10.1016/j.jplph.2018.11.003

Cited by 57 publications

(33 citation statements)

References 107 publications

(83 reference statements)

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“…The role of Se in higher plant metabolism and its essentiality still needs more evidences (Pilon-Smits, 2019). Several reports confirmed that Se can stimulate the growth and plant quality at low applied concentration (Golubkina et al, 2018), improve the photosynthesis rate (Jiang et al, 2017amd Zsiros et al, 2019, and strengthen the plant defense under stress (Bocchini et al, 2018;Hawrylak-Nowak et al, 2018;Singh et al, 2018 andKolbert et al, 2019). On the other hand, nano -selenium (nano-Se) or selenium nanoparticles (Se-NPs) has also distinguished features including low toxicity and high bioactivity comparing with other Se-forms like selenate or selenite or selenomethionine (Djanaguiraman et al, 2018).…”

Section: Introductionmentioning

confidence: 93%

Using of Nano - Selenium in Reducing the Negative Effects of High Temperature Stress on Chrysanthemum morifolium Ramat.

Seliem

Hafez

El-Ramady

2020

Journal of Sustainable Agricultural Sciences

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Section: Introductionmentioning

confidence: 93%

Using of Nano - Selenium in Reducing the Negative Effects of High Temperature Stress on Chrysanthemum morifolium Ramat.

Seliem

Hafez

El-Ramady

2020

Journal of Sustainable Agricultural Sciences

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“…As the genetic mechanism(s) of fungal Se reduction are currently unknown, the reduction pathways are not yet fully understood. Some toxicology studies suggest that Se(IV) is more toxic than Se(VI) in plants (e.g., Kolbert et al, 2018;Molnár et al, 2018), which could be the case for fungi as well. As such, the mechanisms for Se(IV) detoxification may be very effective and efficient, particularly at higher Se loadings.…”

Section: Assessing and Improving The Se Mycoremediation Potentialmentioning

confidence: 99%

Fungal Bioremediation of Selenium-Contaminated Industrial and Municipal Wastewaters

et al. 2020

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Selenium (Se) is an essential element for most organisms yet can cause severe negative biological consequences at elevated levels. The oxidized forms of Se, selenate [Se(VI)] and selenite [Se(IV)], are more mobile, toxic, and bioavailable than the reduced forms of Se such as volatile or solid phases. Thus, selenate and selenite pose a greater threat to ecosystems and human health. As current Se remediation technologies have varying efficiencies and costs, novel strategies to remove elevated Se levels from environments impacted by anthropogenic activities are desirable. Some common soil fungi quickly remove Se (IV and VI) from solution by aerobic reduction to solid or volatile forms. Here, we perform bench-scale culture experiments of two Se-reducing Ascomycota to determine their Se removal capacity in growth media conditions containing either Se(IV) or Se(VI) as well as in Se-containing municipal (∼25 µg/L Se) and industrial (∼2000 µg/L Se) wastewaters. Dissolved Se was measured throughout the experiments to assess Se concentration and removal rates. Additionally, solid-associated Se was quantified at the end of each experiment to determine the amount of Se removed to solid phases (e.g., Se(0) nanoparticles, biomass-adsorbed Se, or internal organic selenoproteins). Results show that under optimal conditions, fungi more efficiently remove Se(IV) from solution compared to Se(VI). Additionally, both fungi remove a higher percentage of Se from the filtered municipal wastewater compared to the industrial wastewater, though cultures in industrial wastewater retained a greater amount of solid-associated Se. Additional wastewater experiments were conducted with supplemental carbohydrate-or glycerin-based carbon products and additional nitrogenand phosphorous-containing nutrients in some cases to enhance fungal growth. Relative to unamended wastewater experiments, supplemental carbohydrates promote Se removal from municipal wastewater but minimally impact industrial wastewater removal. This demonstrates that carbon availability and source impacts fungal Se reduction and removal from solution. Calculations to assess the leaching potential of solid-associated Se from fungal biomass show that wastewater Se release will not exceed regulatory limits. This study highlights the considerable potential for the mycoremediation of Se-contaminated wastewaters.

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“…In general, the content of Se in plant tissues caused toxicity is around 5 mg kg −1 dry weight. The Se tolerance range in crop plants are quietly different, for instance, in rice 2 mg kg −1 dry weight is the maximum levels of Se, in wheat is 4.9 mg kg −1 dry weight, while Dutch clover can tolerant 330 mg kg −1 dry weight (Kolbert et al, 2018). Based on these results, we suggested that a relatively higher dosage of Se-compounds may cause cell toxicity and induce inflammation by increasing COX-2 expression.…”

Section: Discussionmentioning

confidence: 84%

Promoting effect of Se-allylselenocysteine on 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Cheng¹,

Jiang²,

Hsiao³

et al. 2020

JFB

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Se-allylselenocysteine (ASC), an analogue of garlic compound, has been shown to inhibit mammary carcinogenesis in vivo and cell growth in vitro. However, the function of ASC on anti-inflammatory effects remains largely unknown. Therefore, we investigated whether ASC has an anti-inflammatory effect on lipopolysaccharide (LPS) -induced inflammation or an anti-tumour effect promoting on DMBA/TPA-induced skin tumorigenesis and tried to elucidate the mechanisms involved. Herein, the results showed that ASC inhibited LPS-induced production of nitric oxide (NO) with a decreased protein level of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. However, ASC enhanced LPS-induced cyclooxygenase-2 (COX-2) protein levels and mRNA expression. Interestingly, we found for the first time that topical application of ASC on the dorsal skin of DMBA-initiated and TPA-promoted mice significantly accelerated skin tumorigenesis and raised tumour multiplicity as compared to the positive control group (DMBA/TPA). The number of tumours that were 1–3 mm, 3–5 mm, and >5 mm in size per mouse increased in a dose-dependent manner in the ASC pre-treated groups. Pre-treatment with ASC showed a significant increase in the expression of COX-2 compared with the positive control group. In summary, that ASC may modulate the COX-2 protein expression and promoting DMBA/TPA-induced skin cancer in mice.

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Plant selenium toxicity: Proteome in the crosshairs

Cited by 57 publications

References 107 publications

Using of Nano - Selenium in Reducing the Negative Effects of High Temperature Stress on Chrysanthemum morifolium Ramat.

Using of Nano - Selenium in Reducing the Negative Effects of High Temperature Stress on Chrysanthemum morifolium Ramat.

Fungal Bioremediation of Selenium-Contaminated Industrial and Municipal Wastewaters

Promoting effect of Se-allylselenocysteine on 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

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