Plant Secondary Metabolites: Their Food and Therapeutic Importance

Kumar, Satish; Saini, R. K.; Suthar, Priyanka; Kumar, Vikas; Sharma, Rakesh

doi:10.1007/978-981-16-4779-6_12

Cited by 20 publications

(15 citation statements)

References 108 publications

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“…These compounds act as a natural defence system against attack of various microorganisms and environmental stresses. The functions of these compounds are in fact more than just providing protection because of their link to many biochemical pathways and possess a wide range of therapeutic applications (Kumar et al, 2022). On the other hand, the primary metabolites have an active role in the survival of species with regard to functions as photosynthesis and respiration.…”

Section: Plants and Their Secondary Metabolitesmentioning

confidence: 99%

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

et al. 2022

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Sepsis is a severe inflammatory response to systemic infection and is a threatening cause of death in intensive care units. In recent years, a number of studies have been conducted on the protective effect of natural products against sepsis-induced organ injury. However, a comprehensive review of these studies indicating the mechanisms of action of the bioactive compounds is still lacking. In this context, this review aimed to provide an updated analysis of the mechanism of action of plants’ secondary metabolites in the management of sepsis. Scopus, Science Direct, Google Scholar, and PubMed were searched from inception to July 2022. A variety of secondary metabolites were found to be effective in sepsis management including allicin, aloin, cepharanthine, chrysin, curcumin, cyanidin, gallic acid, gingerol, ginsenoside, glycyrrhizin, hesperidin, kaempferol, narciclasine, naringenin, naringin, piperine, quercetin, resveratrol, rosmarinic acid, shogaol, silymarin, sulforaphane, thymoquinone, umbelliferone, and zingerone. The protective effects exerted by these compounds can be ascribed to their antioxidant properties as well as induction of endogenous antioxidant mechanisms, and also via the downregulation of inflammatory response and reduction of biochemical and inflammatory markers of sepsis. These findings suggest that these secondary metabolites could be of potential therapeutic value in the management of sepsis, but human studies must be performed to provide strength to their potential clinical relevance in sepsis-related morbidity and mortality reduction.

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Section: Plants and Their Secondary Metabolitesmentioning

confidence: 99%

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

et al. 2022

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“…Plants, including microgreens, produce a diverse array of phytochemicals, including antioxidants, to combat environmental stressors (Sharma et al, 2022a;Kumar et al, 2022b). While antioxidants are found in various plant parts like leaves, stems, and seeds (Sun et al, 2017;Arumugam et al, 2022), microgreens are particularly noteworthy for their enhanced nutritional profile.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on the antioxidant activities and health benefits of microgreens: current insights and future perspectives

Tallei,

Kepel,

Wungouw

et al. 2023

Int J of Food Sci Tech

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SummaryMicrogreens contain an abundance of antioxidants (glucosinolates, carotenoids, and phenolic compounds), vitamins (C, E, and K), minerals (iron and magnesium), and other nutrients (fibre and omega‐3 fatty acids). They have been shown to promote cardiovascular health, reduce inflammation, combat cancer, manage diabetes, protect the nervous system, and improve digestion. This review investigates the antioxidant content and health implications of microgreens, providing current insights and prospective outlooks. The types of antioxidants found in microgreens, as well as the factors that influence their content, such as species, growing conditions, and harvesting time, are discussed. The review highlights antioxidants' role in cardiovascular health, inflammation reduction, cancer defence, diabetes management, and nervous system protection. The antioxidant properties of microgreen varieties are discussed. The bioavailability of antioxidants from microgreens, culinary applications, and incorporation into the diet are elaborated. The section of future perspectives covers the commercial potential of microgreens, optimal harvest timing, research directions, and potential functional food and nutraceutical uses. The aim and scope of this review are to provide a comprehensive understanding of the antioxidant content in microgreens and their associated health benefits. It also seeks to identify gaps in current research and suggest avenues for future studies, especially concerning their relevance in human health and nutrition.

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“…In general, plant secondary metabolites with high industrial use in agriculture, food, and medicine include steroids, terpenes, alkaloids, antibiotics, vitamins, and sweeteners (Kumar et al, 2022;Ochatt et al, 2022). The use of triterpenoid saponins of the terpene class has been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Pentacyclic triterpenoids saponins pannosides A-E from Tripolium pannonicum

Lee²,

Lee³

et al. 2023

Front. Mar. Sci.

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Five previously undescribed pentacyclic triterpenoid saponins, pannoside A–E (1–5), were discovered from the whole plant of seashore aster, Tripolium pannonicum, collected from the Songdo tidal flat, Incheon, Korea. The planar structures of pannosides were elucidated as pentacyclic triterpenoids bearing sugar moieties and 3-hydroxybutyrate (3-HB) based on the interpretation of the NMR, IR spectroscopic and MS data. The relative configurations of the aglycone and sugar moieties of 1–5 were determined based on careful analysis of ROESY correlations. To determine the absolute configuration of 3-hydroxybutyrate, we utilized the phenylglycine methyl ester (PGME) derivatization with LC-MS chromatographic analysis. Pannoside E (5) exhibited inhibitory activities against diverse cancer cell lines including prostate carcinoma and non-small cell lung carcinoma, with IC50 values of 0.34 and 0.89 μM, respectively. Pannosides are the first triterpenoid saponin isolated from T. pannonicum, implying that undiscovered secondary metabolites from a halophyte could be a good source of bioactive compounds.

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Plant Secondary Metabolites: Their Food and Therapeutic Importance

Cited by 20 publications

References 108 publications

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

A comprehensive review on the antioxidant activities and health benefits of microgreens: current insights and future perspectives

Pentacyclic triterpenoids saponins pannosides A-E from Tripolium pannonicum

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