Plant responses to extracellular nucleotides: Cellular processes and biological effects

Jeter, Collene; Roux, Stanley J.

doi:10.1007/s11302-005-3981-6

Cited by 20 publications

(10 citation statements)

References 53 publications

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“…Many non‐neural as well as neuronal cells express multiple receptors,37 and this poses problems about how they mediate interacting physiological events. It is becoming clear that the purinergic signaling system has an early evolutionary basis (see Ref 93) with fascinating recent studies showing cloned receptors in two primitive invertebrates, Dictyostelium and Schistosoma that resemble mammalian P2X receptors94,95 and ATP signaling in plants has also been described 96–98…”

Section: Receptors To Purines and Pyrimidinesmentioning

confidence: 99%

Purinergic signaling

Burnstock

Verkhratsky

2012

WIREs Membr Transp Signal

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The concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5 -triphosphate (ATP) was a transmitter in non-adrenergic, non-cholinergic inhibitory nerves in the guinea pig taenia coli. Subsequently, ATP was identified as a cotransmitter in sympathetic and parasympathetic nerves, and it is now recognized that ATP acts as a cotransmitter in most nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a fast excitatory neurotransmitter or neuromodulator and has potent long-term (trophic) roles in cell proliferation, differentiation, and death in development and regeneration, as well as in disease. Three subclasses of receptors to purines and pyrimidines have been identified, P1 adenosine receptors (with four subtypes), P2X ionotropic nucleotide receptors (seven subtypes), and P2Y metabotropic nucleotide receptors (eight subtypes). ATP is released physiologically by many different cell types by mechanical deformation, and after release ATP undergoes rapid enzymatic degradation by ectonucleotidases. Purinergic receptors appeared early in evolution and have a widespread distribution on many different non-neuronal cell types as well as neurons. There is evidence for the involvement of purinergic signaling in embryonic development and in the activities of stem cells. There is a rapidly growing literature about the pathophysiology of purinergic signaling, and there are therapeutic developments for a variety of diseases, including stroke and thrombosis, osteoporosis, kidney failure, bladder incontinence, cystic fibrosis, dry eye, cancer, and disorders of the CNS, such as Alzheimer's, Parkinson's, and Huntington's disease, multiple sclerosis, epilepsy, migraine, and neuropsychiatric disorders.sacral parasympathetic nerves, and NANC transmission was later shown in the urinary bladder and vascular system. ATP AS A TRANSMITTER IN NANC NERVESThe next step was to try to identify the transmitter released during NANC inhibitory transmission in the gut and by NANC excitatory transmission in the urinary bladder. Several criteria needed to be satisfied to establish a neurotransmitter: synthesis and storage in nerve terminals; release by a Ca 2+ -dependent mechanism; mimicry of the nerve-mediated responses by the exogenously applied transmitter; inactivation by ectoenzymes and/or neuronal uptake; and parallel block or potentiation of responses to stimulation by nerves and exogenously applied transmitter. 116

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Section: Receptors To Purines and Pyrimidinesmentioning

confidence: 99%

Purinergic signaling

Burnstock

Verkhratsky

2012

WIREs Membr Transp Signal

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“…There has been increasing recent interest in the roles of extracellular ATP in plant growth and regeneration. Excellent recent reviews about purinergic signaling in plants are also available 32–36. Extracellular ATP is emerging as an important plant signaling molecule capable of mobilizing intracellular second messengers, such as Ca 2+ , nitric oxide (NO), and reactive oxygen species 37.…”

Section: Plantsmentioning

confidence: 99%

Evolution of P2X receptors

Burnstock

Verkhratsky

2012

WIREs Membr Transp Signal

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Purines appear to be the most primitive and widespread chemical messengers in all kingdoms of the Domain Eucarya. There is evidence for purinergic signaling in plants, invertebrates, and lower vertebrates from protozoa to birds. Much is based on pharmacological studies, but important recent papers have utilized the techniques of molecular biology, and ATP-gated ion channels (ionotropic purinoceptors) have been cloned and characterized in primitive invertebrates, including the social amoeba Dictyostelium and the platyhelminth Schistosoma, as well as the green algae Ostreococcus. These ancient purinoceptors resemble P2X receptors identified in mammals. This suggests that contrary to earlier speculations, P2X ion channel receptors appeared early in evolution, while G protein-coupled P1 and P2Y receptors were introduced either at the same time or perhaps even later. The absence of gene coding for P2X receptors in some animal groups (e.g., in some insects, roundworm Caenorhabditis elegans, and the plant Arabidopsis), in contrast to the potent pharmacological actions of nucleotides in the same species, suggests that novel receptors are still to be discovered. 

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“…7 for details). Moreover, injury-induced ATP release and stimulation of P2-like receptors mediate wound responses in plants by mechanisms similarly linked to NADPH oxidase and the expression of wound response genes [74,75]. Recently, ATP release in plant roots was found associated with regions of active growth and cell expansion, events also critically dependent on NADPH oxidase activation and oxidant generation [76].…”

Section: Nadph Oxidase Activation In Atp-mediated Stress/wound Responsesmentioning

confidence: 99%

Purinergic Signaling in Wound Healing and Airway Remodeling

Vliet

Bove

2011

Purinergic Regulation of Respiratory Diseases

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Airway epithelia are continuously damaged by airborne pollutants, pathogens and allergens, and they rely on intrinsic mechanisms to restore barrier integrity. Epithelial repair is a multi-step process including cell migration into the wounded area, proliferation, differentiation and matrix deposition. Each step requires the secretion of various molecules, including growth factors, integrins and matrix metalloproteinases. Evidence is emerging that purinergic signaling promotes repair in human airway epithelia. An injury induces ATP release, which binds P2Y(2) receptors (P2Y(2)Rs) to initiate protein kinase C (PKC)-dependent oxidative activation of TNFα-converting enzyme (TACE), which then releases the membrane-bound ligands of the epidermal growth factor receptor (EGFR). The P2Y(2)R- and EGFR-dependent signaling cascades converge to induce mediator release, whereas the latter also induces cytoskeletal rearrangement for cell migration and proliferation. Similar roles for purinergic signaling are reported in pulmonary endothelial cells, smooth muscle cells and fibroblasts. In chronic airway diseases, the aberrant regulation of extracellular purines is implicated in the development of airway remodeling by mucus cell metaplasia and hypersecretion, excess collagen deposition, fibrosis and neovascularization. This chapter describes the crosstalk between these signaling cascades and discusses the impact of deregulated purinergic signaling in chronic lung diseases.

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Plant responses to extracellular nucleotides: Cellular processes and biological effects

Cited by 20 publications

References 53 publications

Purinergic signaling

Purinergic signaling

Evolution of P2X receptors

Purinergic Signaling in Wound Healing and Airway Remodeling

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