Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Ruan, Jing; Zheng, Chang; Lu, Qin; Liu, Yanxia; Han, Lifeng; Yu, Haiyang; Zhang, Yi; Wang, Tao

doi:10.3390/molecules21081047

Cited by 19 publications

(13 citation statements)

References 149 publications

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“…Dammarane-type triterpenoids are tetracyclic triterpenoids whose structural feature is characterized by a 6/6/6/5 ring system with H-5α, H-9α, H-13β, three β-CH 3 groups on C-4 (CH 3 -28), C-8 (CH 3 -20), C-10 (CH 3 -19), one α-CH 3 group on C-14 (CH 3 -30), C-17β-side chain, and 20 R or S configuration ( Figure 16 ) [ 71 ]. These compounds are widely distributed in various plant families such as Araliaceae ( Aralia sp., Panax sp., Polyscias sp.…”

Section: Dammarane Triterpenoidsmentioning

confidence: 99%

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

et al. 2022

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The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C23-terpenoids, sesterterpenoids (C25), dammarane triterpenoids (C30), and uncommon triterpenoids (C20+C10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated.

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Section: Dammarane Triterpenoidsmentioning

confidence: 99%

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

et al. 2022

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“…Dammarane-type triterpenes belong to the class of tetracyclic triterpenes; they represent a wide range of compositions spread in a variety of plant families such as Arialiaceae, Betulacease, Meliaceae, etc. [98]. Their basic structure is represented in Figure 8.…”

Section: Dammarane-type Triterpenoidsmentioning

confidence: 99%

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

et al. 2020

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Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.

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“…In Chinese traditional medicine, the roots of Panax ginseng C. A. Meyer (ginseng) (Araliaceae), known locally as "renshen", are used as a complementary and alternative herbal supplement to support cancer chemotherapy [76]. The ginsenosides, containing mainly dammarane-type tetracyclic triterpene saponins, have been characterized as the major components of ginseng, and have attracted a great deal of attention owing to their promising bioactivities, including potential antitumor efficacy [77,78].…”

Section: Dammarane-type Triterpenoids I: Ginsenoside Sapogeninsmentioning

confidence: 99%

“…In analogous work, the antitumor potential has been investigated extensively for the PPD-type ginseng saponins, including the 20(S)-ginsenosides Rh 2 (G-Rh2, 30) and Rg 3 (G-Rg3, 31), and ginsenosides Rh 3 (G-Rh3, 32), and Rk 2 (G-Rk2, 33) (▶ Fig. 6) [76,78,79,96]. Of these, G-Rh2 (30) was up to 10-fold more active than G-Rg3 (31) toward a panel of human cancer cells [79], indicating that introducing an additional sugar unit in the C-3 saccharide moiety decreases the cytotoxic potency of G-Rh2 (30).…”

Section: Dammarane-type Triterpenoids Ii: Ginsenosidesmentioning

confidence: 99%

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Ren

Kinghorn

2019

Planta Med

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Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as potential anticancer agents. In the present review, the anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic derivatives, including examples of lupane-, oleanane-, ursane-, and cucurbitane-type pentacyclic triterpenoids, along with dammarane-type tetracyclic triterpenes including ginsenosides and their sapogenins and dichapetalins, which have been characterized as antitumor leads from higher plants. Preliminary structure-activity relationships and reported mechanisms of the antineoplastic-related activity are included. Prior studies for triterpenoids of plant origin are supportive of additional work being conducted on the more detailed biological and mechanistic evaluation for the progression of this type of natural products as possible cancer chemotherapeutic agents.

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Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Cited by 19 publications

References 149 publications

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

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