Drift or misapplication of maleic hydrazide (MH) to tobacco (Nicotiana tabacum L.) sometimes effects neighboring soybean [Glycine max (L.) Merr.] fields. Our objective was to determine the effects of various rates and timings of MH application on soybean reproductive development and yield. Applications of 0.34 to 3.4 kg a.i. ha−1 were applied to soybean during the R3 to R6 growth stages. Significant (P<0.05) yield reductions from 30 to 100% occured when even low rates of MH were applied to soybean at growth stages R3 and R4. Yield losses occurred primarily as a result of decreased numbers of pods per plant. Injured soybean plants remained green until killing frosts. Plants treated with MH at the R5 and R6 stages experienced no yield loss and matured normally. Planting shorter‐season soybean cultivars early could result in soybean being past the sensitive stages when MH is applied, resulting in little or no injury if misapplication or drift occurs.