Plant protein hydrogel as a delivery system of curcumin: Characterization and in vitro release Kinetics

Gupta, Sakshi; Ghoshal, Gargi

doi:10.1016/j.fbp.2023.10.007

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…To better understand the mechanism of curcumin release in the Fuc/Car/SPI delivery system, the release profiles of hydrogels were successfully fitted onto Korsmeyer–Peppas Kinetics with a high correlation coefficient (R 2 = 0.99). This result was consistent with the report by Gupta et al [ 31 ]. The result of the model indicated that the k and n values were 22.73 and 0.44.…”

Section: Resultssupporting

confidence: 94%

An Effective Method to Prepare Curcumin-Loaded Soy Protein Isolate Nanoparticles Co-Stabilized by Carrageenan and Fucoidan

Chen,

Cai,

et al. 2024

Pharmaceuticals

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In this study, a novel and simple strategy is proposed based on 3D network formed by easily blending polysaccharide carrageenan (Car) and fucoidan (Fuc) without a crosslinker. The Fuc/Car dual coating effectively assists the self-assembly of soy protein-isolated (SPI)/curcumin (Cur, C) composite microcapsules (SPI/C) and achieves an excellent curcumin encapsulation efficiency (EE) up to 95.28% with a 4.16% loading capacity (LC) under optimal conditions. The resulting nanocomposites achieved a satisfying redispersibility in aqueous solution and enhanced the water solubility with a lower size dispersity index (PDI) of 0.12 and a larger zeta potential of −29.67 mV. The Fuc/Car double-layer network not only dramatically improved its thermal stability and photostability, but also provided controlled release and enhanced antioxidant activity in in vitro conditions. The underlying mechanism of the self-assembly of the curcumin-loaded nanoparticles was also addressed. The results proved the feasibility of the encapsulation of unstable hydrophobic bioactive substances (curcumin) with the dual anionic polysaccharide Fuc/Car co-stabilized SPI nanoparticles. This study paves the way for an alternative way of developing novel curcumin delivery systems and will have broad prospects in the pharmaceutical industries.

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Section: Resultssupporting

confidence: 94%