Plant pregnanes

Deepak, Desh; Khare, Anakshi; Khare, Maheshwari P.

doi:10.1016/0031-9422(89)80327-9

Cited by 61 publications

(39 citation statements)

References 75 publications

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“…Due to gene recombination during evolution, endophytic microorganisms have often developed biochemical abilities to produce compounds either similar or identical to those produced by their host plants [4]. On the other hand, it has been reported that the pregnane steroids are distributed not only in marine organisms such as corals, sponges, and gorgonians [19,[21][22][23], but also in terrestrial plants [24]; however, they are rare in fungi.…”

Section: Resultsmentioning

confidence: 99%

Metabolites from an Endophytic Fungus Sphaceloma sp. LN‐15 Isolated from the Leaves of Melia azedarach

Zhang

Gao

et al. 2009

Lipids

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Two new natural compounds, a symmetrical disulfide dimer didodecyl 3,3''-dithiodipropionate (1) and a pregnane steroid 5,16-pregnadien-3beta-ol-20-one acetate (2), were isolated together with two known compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) and ergosterol peroxide (4), from the ethyl acetate soluble extract of fermentation broth of an endophytic fungus, Sphaceloma sp. LN-15 isolated from the leaves of Melia azedarach L. and grown in pure culture. Their structures were determined on the basis of spectroscopic methods including 1D and 2D nuclear magnetic resonance spectroscopy (NMR) experiments and by mass spectrometric measurements (MS). These fungal metabolites were isolated for the first time from the genus Sphaceloma. The structure of 1 was also confirmed by chemical synthesis.

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Section: Resultsmentioning

confidence: 99%

Metabolites from an Endophytic Fungus Sphaceloma sp. LN‐15 Isolated from the Leaves of Melia azedarach

Zhang

Gao

et al. 2009

Lipids

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“…Pregnanes are C‐21 steroidal compounds (Figure ) having perhydro‐1,2‐cyclopentanophenanthrene ring system with β‐oriented angular methyl groups at C‐10 and C‐13, and a two carbon side‐chain at C‐17 [94]. Usually, pregnane derivatives possess a β‐configuration at C‐14 and bear a hydroxy functionality at this position.…”

Section: Chemistrymentioning

confidence: 99%

“…Usually, pregnane derivatives possess a β‐configuration at C‐14 and bear a hydroxy functionality at this position. The configuration of pregnane derivatives at C‐5 is usually α and C‐3 hydroxyl group is always β‐oriented [94,95]…”

Section: Chemistrymentioning

confidence: 99%

A review on ethnobotany, phytochemistry and pharmacology of plant genus C aralluma R. Br

Adnan

Jan

Mussarat

et al. 2014

Journal of Pharmacy and Pharmacology

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Objectives Caralluma is a xerophytic genus used as traditional medicine for the treatment of diabetes, inflammation, leprosy, obesity and rheumatism. Objectives of this review are to establish a relationship between traditional uses and scientific studies by critically evaluating the available fragmented literature on ethnobotany, pharmacology, phytochemistry and toxicology of genus Caralluma. Key findings Ethnomedical uses of Caralluma have been recorded from various countries such as China, India, Iran and Pakistan for six major classes of diseases including diabetes and gastrointestinal disorders. This review indicated the efficacy of genus Caralluma in several in vitro and in vivo pharmacological properties such as antimicrobial, antioxidant and anticancer activity. These bioactivity might be due to the presence of certain classes of compounds in genus Caralluma including pregnane glycosides, flavonoid glycosides and flavones. Summary Traditional uses and scientific evaluation of Caralluma indicates that it is one of the most widely used genus in some parts of the world. Further studies on the structural activity relationship of some of the isolated compound may improve their biological potency as well as scientific exploitation of traditional uses of the genus.

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“…The species of Caralluma found in India are edible and form a part of the traditional medicine system of the country. Plants belonging to the genus Caralluma are rich in esterified polyhydroxy pregnane glycosides, some of which showed antitumour activity and others were postulated as precursors of cardenolides (Deepak et al, 1989(Deepak et al, , 1997. Rizwani et al (1990) and Ramesh et al (1999) reported the presence of flavone glycosides.…”

Section: Introductionmentioning

confidence: 99%

Callus Culture and in vitro Shoot Regeneration from Stem Segments of Endemic and Medicinally Important Caralluma lasiantha (Wight) N.E.Br.

2016

IJSR

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Plant pregnanes

Cited by 61 publications

References 75 publications

Metabolites from an Endophytic Fungus Sphaceloma sp. LN‐15 Isolated from the Leaves of Melia azedarach

Metabolites from an Endophytic Fungus Sphaceloma sp. LN‐15 Isolated from the Leaves of Melia azedarach

A review on ethnobotany, phytochemistry and pharmacology of plant genus C aralluma R. Br

Callus Culture and in vitro Shoot Regeneration from Stem Segments of Endemic and Medicinally Important Caralluma lasiantha (Wight) N.E.Br.

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