Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells

Papuc, Camelia; Goran, G. V.; Predescu, Corina; Tudoreanu, Liliana; Ștefan, Georgeta

doi:10.1080/10408398.2020.1815644

Cited by 33 publications

(21 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence is building up to address the broad application prospects of CGA in the fields of medicine, food, and husbandry (Chen et al, 2018;Naveed et al, 2018;Lu et al, 2020;Papuc et al, 2020). Our experiment found that dietary supplementation with CGA contributed to the growth and carcass performance of pigs (data not shown), fitting well with a previous report using a finishing-pig model (Xu et al, 2019).…”

Section: Discussionsupporting

confidence: 90%

Dietary Supplementation With Chlorogenic Acid Derived From Lonicera macranthoides Hand-Mazz Improves Meat Quality and Muscle Fiber Characteristics of Finishing Pigs via Enhancement of Antioxidant Capacity

et al. 2021

View full text Add to dashboard Cite

Chlorogenic acid (CGA), one of the most abundant polyphenol compounds in nature, is regarded as a potential feed additive to promote animal health and enhance the meat products’ quality via its various biological properties. The current study aims: (1) to determine whether dietary CGA supplementation improves meat quality and muscle fiber characteristics, and (2) to ascertain whether the corresponding improvement is associated with enhancing the antioxidant capacity of the finishing pigs. Thirty-two (Large × White × Landrace) finishing pigs with an average initial body weight of 71.89 ± 0.92 kg were allotted to 4 groups, and each was fed diets supplemented with 0, 0.02, 0.04, or 0.08% (weight/weight) of CGA. The meat quality traits, muscle fiber characteristics, and the serum and muscle antioxidant capacity were assessed. Results suggested that, compared with the control group, dietary CGA supplementation at a level of 0.04% significantly decreased the b∗ value and distinctly increased the inosinic acid content of longissimus dorsi (LD) and biceps femoris (BF) muscles (P < 0.01). Moreover, dietary supplementation with 0.04% of CGA markedly improved the amino acid composition of LD and BF muscles, as well as augmented the mRNA abundance of Nrf-2, GPX-1, MyoD, MyoG, and oxidative muscle fiber (I and IIa) in LD muscle (P < 0.05). This result indicates that a diet supplemented with 0.04% of CGA promotes myogenesis and induces a transformation toward more oxidative muscle fibers in LD muscle, subsequently improving meat quality. Besides, dietary supplementation with 0.02% and 0.04% of CGA notably enhanced the serum GSH-PX level (P < 0.01). Considering all these effects are closely related to the alteration of antioxidant activities of the finishing pigs, the underlying metabolism is likely connected to the boosting of their antioxidant capacity induced by dietary CGA.

show abstract

Section: Discussionsupporting

confidence: 90%

Dietary Supplementation With Chlorogenic Acid Derived From Lonicera macranthoides Hand-Mazz Improves Meat Quality and Muscle Fiber Characteristics of Finishing Pigs via Enhancement of Antioxidant Capacity

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Polyphenols reduce the absorption of glucose in the intestine and slow down the digestion of carbohydrates as a result of interaction with α-amylase (in the mouth and intestines) and α-glucosidase (in the intestine), as well as with sodium-dependent glucose transporter (SLGT1) [82][83][84]. Additionally, these compounds stimulate insulin secretion in the pancreas, activate insulin receptors, and regulate the release of glucose from the liver [83,85,86]. Polyphenols may also affect gene expression and intracellular signaling pathways [87].…”

Section: Impact Of Chokeberry On Carbohydrate Metabolismmentioning

confidence: 99%

Chokeberry (A. melanocarpa (Michx.) Elliott)—A Natural Product for Metabolic Disorders?

2022

View full text Add to dashboard Cite

Abnormal metabolism of substances in the body can result in metabolic disorders which include obesity, cardiovascular diseases, diabetes, hypertension, chronic kidney disease, liver disease, or cancer. Foods rich in antioxidants can help to prevent and treat various types of disorders. Chokeberry fruits are rich in polyphenols, especially cyanidins, and therefore, can show a beneficial health effect. The aim of this study was to summarize and systematize reports about the effects of chokeberry on various metabolic parameters. Studies from 2000 to 2021, published in the PubMed and Google Scholar databases, were reviewed. The review of studies shows that chokeberry may have a positive effect in dyslipidemia and hypertension and may increase the body’s antioxidant defense mechanisms. The anti-inflammatory effect, in turn, may translate into a reduction in the risk of metabolic disorders over a longer period of use. Changes in glucose levels were reported by studies in which the intervention lasted more than 10 weeks in patients with carbohydrate metabolism disorders. The effects of protecting the liver, inhibiting platelet aggregation, lowering uric acid levels, and having a protective effect on the kidneys require additional confirmation in human clinical trials. Consumption of chokeberry fruit did not impact on anthropometric measurements; however, it seems that chokeberry fruit can be recommended in many metabolic disorders due to the richness of bioactive ingredients.

show abstract

“…These protection systems control the production of free radicals, assuring a balance between antioxidants and prooxidants [ 56 ], but excessive ROS production in mitochondria leads to the damaging of proteins, lipids, and DNA, then decreases energy production efficiency and ultimately improves mitochondrial ROS production [ 4 , 38 ]. Higher ROS levels lead to significant mitochondrial dysfunctions and oxidative stress [ 4 , 38 , 57 ]. Studies in chickens have also shown that high temperatures induce both oxidation of lipids and proteins [ 58 , 59 ].…”

Section: Heat Stress and Oxidative Stress In Broiler Chickensmentioning

confidence: 99%

Heat Stress in Broiler Chickens and the Effect of Dietary Polyphenols, with Special Reference to Willow (Salix spp.) Bark Supplements—A Review

et al. 2021

View full text Add to dashboard Cite

Over the last decade, there has been a growing interest in the use of a wide range of phytoadditives to counteract the harmful effects of heat stress in poultry. Willow (Salix spp.) is a tree with a long history. Among various forms, willow bark is an important natural source of salicin, β-O-glucoside of saligenin, but also of polyphenols (flavonoids and condensed tannins) with antioxidant, antimicrobial, and anti-inflammatory activity. In light of this, the current review presents some literature data aiming to: (1) describe the relationship between heat stress and oxidative stress in broilers, (2) present or summarize literature data on the chemical composition of Salix species, (3) summarize the mechanisms of action of willow bark in heat-stressed broilers, and (4) present different biological effects of the extract of Salix species in different experimental models.

show abstract

Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells

Cited by 33 publications

References 171 publications

Dietary Supplementation With Chlorogenic Acid Derived From Lonicera macranthoides Hand-Mazz Improves Meat Quality and Muscle Fiber Characteristics of Finishing Pigs via Enhancement of Antioxidant Capacity

Dietary Supplementation With Chlorogenic Acid Derived From Lonicera macranthoides Hand-Mazz Improves Meat Quality and Muscle Fiber Characteristics of Finishing Pigs via Enhancement of Antioxidant Capacity

Chokeberry (A. melanocarpa (Michx.) Elliott)—A Natural Product for Metabolic Disorders?

Heat Stress in Broiler Chickens and the Effect of Dietary Polyphenols, with Special Reference to Willow (Salix spp.) Bark Supplements—A Review

Contact Info

Product

Resources

About