Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR–ERK pathway

Potapovich, Alla I.; Lulli, Daniela; Fidanza, Paolo; Kostyuk, Vladimir; Luca, Chiara De; Pastore, Saveria; Korkina, Liudmila

doi:10.1016/j.taap.2011.06.007

Cited by 106 publications

(103 citation statements)

References 39 publications

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“…It has been published recently [23] that the glycosylated plant phenylpropanoids (polyphenols) baicalein and verbascoside protected cultured human keratinocytes against a broad band UVA + UBV simulating solar UV irradiation better than benzophenone-3. According to this paper and other publications [23,68], baicalein and verbascoside protected cell viability via multiple pathways: partly by physical UVA + UVB absorption, partly by direct free radical scavenging (chemical protection), and/or targeting adaptive/pro-survival, such as Nrf2-connected pathways in keratinocytes (biological protection).…”

Section: Pre-selection Of Sun-protective Secondary Plant Metabolitesmentioning

confidence: 70%

“…On the other hand, induction of phase I enzymes could accelerate SPMs metabolism in the skin. There are data confirming that AhR receptor activation/inhibition by definite plant polyphenols correlate with the consequent CYP1 behaviour [68]. Resveratrol and its glycoside polydatin augment metabolic and inflammatory responses of human keratinocytes to UVA + UVB radiation or to exogenous FICZ [69], which allowed for issuing a warning about possible risks of resveratrol in sun protective cosmetics.…”

Section: Effects Of Secondary Plant Metabolites On Metabolic Responsementioning

confidence: 91%

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Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

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Topical sun protective cosmetics (sunscreens, pre-and post-sun) have been intensively developed and produced to protect human skin against solar irradiation-associated damages/pathologies. Unfortunately, routine cosmetics for sun protection containing synthetic organic and/or physical sunscreens could exert adverse effects towards human organisms and bring undesirable ecological changes. Terrestrial and marine plant species, being exposed to sun light for hundreds of millions of years, have evolved two pro-survival strategies: effective protection against/adaptation to its deleterious effects and the use of solar energy for photosynthesis/photo-biochemical reactions. Secondary plant metabolites (SPM) are primary sensors of solar energy and mediators of its use (photo-sensitisers) or neutralisation (photo-protectors). A similar double photo-protective/photo-sensitising system is built in within human skin. Modern development of toxicologically/ecologically safe yet effective sun-protective cosmetics attempts to pre-select photo-stable and non-phototoxic SPMs that provide broad UVA + UVB sunscreen, free radical scavenging and direct antioxidant defence, endogenous antioxidant rescue, induction of antioxidant enzymes (indirect antioxidant defence), and normalisation of metabolic and immune responses to UVA + UVB. Proper formulation of sun protective cosmetics should assure targeted delivery of photo-active SPMs to definite skin layers to invigorate the built in photo-chemical skin barrier.

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Section: Pre-selection Of Sun-protective Secondary Plant Metabolitesmentioning

confidence: 70%

Section: Effects Of Secondary Plant Metabolites On Metabolic Responsementioning

confidence: 91%

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

Self Cite

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“…PD activates aryl hydrocarbon receptor machinery in UV-exposed keratinocytes through down-regulating the gene expression of pro-inflammatory cytokines/enzymes, suppressing interferon gamma-inducible protein 10 (IP-10) release, and up-regulating IL-8 level (Potapovich et al, 2011), opposing enhanced monocyte chemotactic protein-1 (MCP-1) and IP-10 transcription/synthesis (Pastore et al, 2012). PD is also able to modulate IL-6, IL-8 and TNF-a gene expression, increase the release of human b-defensin 2 and gene expression of heat shock protein 70B 0 in heat-stressed HaCaT (Ravagnan et al, 2013).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

211

162

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Context: Polydatin, also named piceid (3,4 0 ,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD. Objective: The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990. Materials and methods: The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI. Results: Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc. Conclusion: A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.

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“…Naturally occurring antioxidants such as polyphenolic plant constituents have been the focus of research studies concerned with the development of novel anti-inflammatory and chemopreventive agents in skin [29][30][31][32]. One of the most extensively studied natural agents in skin is green and black tea (Camellia sinensis) and their polyphenolic constituents, which have been shown to prevent inflammation by inhibiting the synthesis of IL-1α in mouse skin.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Aspalathus linearis and Cyclopia spp. Extracts in a UVB/Keratinocyte (HaCaT) Model Utilising Interleukin-1α Accumulation as Biomarker

et al. 2016

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Ultraviolet B (UVB) radiation is one of the major predisposing risk factors of skin cancer. The anticancer and photoprotective effects of unoxidized rooibos (Aspalathus linearis) and honeybush (Cyclopia) herbal teas, containing high levels of dihydrochalones and xanthones, respectively, have been demonstrated in skin cancer models in vivo. In the current study, the anti-inflammatory effects of methanol and aqueous extracts of these herbal teas were investigated in a UVB/HaCaT keratinocyte model with intracellular interleukin-1α (icIL-1α) accumulation as a biomarker. Extracts of green tea (Camellia sinensis) served as benchmark. Both extracts of green tea and rooibos, as well as the aqueous extract of C. intermedia, enhanced UVB-induced inhibition of cell viability, proliferation and induction of apoptosis, facilitating the removal of icIL-1α. The underlying mechanisms may involve mitochondrial dysfunction exhibiting pro-oxidant responses via polyphenol-iron interactions. The methanol extracts of honeybush, however, protected against UVB-induced reduction of cell growth parameters, presumably via antioxidant mechanisms that prevented the removal of highly inflamed icIL-1α-containing keratinocytes via apoptosis. The dual antioxidant and/or pro-oxidant role of the polyphenolic herbal tea constituents should be considered in developing preventive strategies against UVB-induced skin carcinogenesis. The indirect removal of UVB damaged keratinocytes by herbal tea extracts via apoptosis may find application in the prevention of photo-induced inflammation.

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Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR–ERK pathway

Cited by 106 publications

References 39 publications

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Polydatin: A review of pharmacology and pharmacokinetics

Anti-Inflammatory Effects of Aspalathus linearis and Cyclopia spp. Extracts in a UVB/Keratinocyte (HaCaT) Model Utilising Interleukin-1α Accumulation as Biomarker

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