Plant polyphenols, chemoreception, taste receptors and taste management

Canivenc-Lavier, Marie-Chantal; Neiers, Fabrice; Briand, Loı̈c

doi:10.1097/mco.0000000000000595

Cited by 11 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structural requirements for flavonoids to activate the bitter receptors seem to be linked to the presence of two or three hydrogen bond donor sites, one hydrogen bond acceptor site, and two aromatic ring structures, one of which must be hydrophobic, thus allowing us to predict the potential bitterness of these bioactive molecules [ 42 ]. On the other hand, epicatechins upregulate ghrelin release through gut TAS2R activation, apigenin displays anti-inflammatory effects in respiratory tract infections through an activation mechanism, and methoxy flavones act at the same level as antagonists, thus opening up new perspectives on phytotherapy and health strategies [ 43 , 44 , 45 ]. To this purpose, caffeic acid derivatives were recently studied as some of the biologically active metabolites of propolis, showing a large spectrum of action.…”

Section: Resultsmentioning

confidence: 99%

From Primary Data to Ethnopharmacological Investigations on Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson as a Remedy against Gastric Ailments in Valmalenco (Italy)

Bottoni,

Martinelli,

Maranta

et al. 2024

Plants

View full text Add to dashboard Cite

(1) Background: Within the framework of the European Interreg Italy–Switzerland B-ICE & Heritage project (2018–2022), this study originated from a three-year ethnobotanical survey in Valmalenco (Sondrio, Italy). Following a preliminary work published by our group, this research further explored the folk therapeutic use of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (Asteraceae) for dyspepsia disorders, specifically its anti-inflammatory potential at a gastrointestinal level. (2) Methods: Semi-structured interviews were performed. The bitter taste was investigated through molecular docking software (PLANTS, GOLD), while the anti-inflammatory activity of the hydroethanolic extract, infusion, and decoction was evaluated based on the release of IL-8 and IL-6 after treatment with TNFα or Helicobacter pylori. The minimum inhibitory concentration and bacterial adhesion on the gastric epithelium were evaluated. (3) Results: In total, 401 respondents were interviewed. Molecular docking highlighted di-caffeoylquinic acids as the main compounds responsible for the interaction with bitter taste receptors. The moderate inhibition of IL-6 and IL-8 release was recorded, while, in the co-culture with H. pylori, stronger anti-inflammatory potential was expressed (29–45 μg/mL). The concentration-dependent inhibition of H. pylori growth was recorded (MIC = 100 μg/mL), with a significant anti-adhesive effect. (4) Conclusions: Confirming the folk tradition, the study emphasizes the species’ potentiality for dyspepsia disorders. Future studies are needed to identify the components mostly responsible for the biological effects.

show abstract

Section: Resultsmentioning

confidence: 99%

From Primary Data to Ethnopharmacological Investigations on Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson as a Remedy against Gastric Ailments in Valmalenco (Italy)

Bottoni,

Martinelli,

Maranta

et al. 2024

Plants

View full text Add to dashboard Cite

show abstract

“…Therefore, one may speculate that the AIA of a given class is largely dependent on its ability to activate bitter taste receptors. Indeed, experts in taste sciences have already underlined that polyphenols, among which flavonoids represent the biggest class, bind to the oral and extraoral bitter taste receptors TAS2Rs, which modulate the signaling pathways involved in anti-inflammatory processes, with consequent health beneficial effects [ 32 ]. Our present results support their conclusions.…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals and Inflammation: Is Bitter Better?

Dragoș

Petran

Gradinaru

et al. 2022

Plants

View full text Add to dashboard Cite

The taste of a herb influences its use in traditional medicine. A molecular basis for the taste-based patterns ruling the distribution of herbal (ethno) pharmacological activities may not be excluded. This study investigated the potential correlations between the anti-inflammatory activity (AIA) and the phytocompound taste and/or its chemical class. The study relies on information gathered by an extensive literature (articles, books, databases) search and made public as PlantMolecularTasteDB. Out of a total of 1527 phytotastants with reliably documented taste and structure available in PlantMolecularTasteDB, 592 (for each of which at least 40 hits were found on PubMed searches) were included in the statistical analysis. A list of 1836 putative molecular targets of these phytotastants was afterwards generated with SwissTargetPrediction tool. These targets were systematically evaluated for their potential role in inflammation using an international databases search. The correlations between phytochemical taste and AIA, between chemical class and AIA, and between the taste and the number of inflammation related targets were statistically analyzed. Phytochemical taste may be a better predictor of AIA than the chemical class. Bitter phytocompounds have a higher probability of exerting AIA when compared with otherwise phytotastants. Moreover, bitter phytotastants act upon more inflammation related targets than non-bitter tasting compounds.

show abstract

“…Also called TASRs, theses taste receptors mediate sweet and umami perceptions through the TAS1R family (n = 3) and bitterness perceptions through the TAS2Rs family (n = 25). Depending on their chemical nature, polyphenols may act as activators or inhibitors of bitter taste receptors, and combinations of polyphenols (or herbal mixtures) may be used to modulate the acceptability of bitterness [ 273 ].…”

Section: Taste Interactions: a New Endpoints For Phytoestrogensmentioning

confidence: 99%

Phytoestrogens and Health Effects

Canivenc-Lavier

Bennetau-Pelissero

2023

Nutrients

Self Cite

View full text Add to dashboard Cite

Phytoestrogens are literally estrogenic substances of plant origin. Although these substances are useful for plants in many aspects, their estrogenic properties are essentially relevant to their predators. As such, phytoestrogens can be considered to be substances potentially dedicated to plant–predator interaction. Therefore, it is not surprising to note that the word phytoestrogen comes from the early discovery of estrogenic effects in grazing animals and humans. Here, several compounds whose activities have been discovered at nutritional concentrations in animals and humans are examined. The substances analyzed belong to several chemical families, i.e., the flavanones, the coumestans, the resorcylic acid lactones, the isoflavones, and the enterolignans. Following their definition and the evocation of their role in plants, their metabolic transformations and bioavailabilities are discussed. A point is then made regarding their health effects, which can either be beneficial or adverse depending on the subject studied, the sex, the age, and the physiological status. Toxicological information is given based on official data. The effects are first presented in humans. Animal models are evoked when no data are available in humans. The effects are presented with a constant reference to doses and plausible exposure.

show abstract

Plant polyphenols, chemoreception, taste receptors and taste management

Cited by 11 publications

References 46 publications

From Primary Data to Ethnopharmacological Investigations on Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson as a Remedy against Gastric Ailments in Valmalenco (Italy)

From Primary Data to Ethnopharmacological Investigations on Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson as a Remedy against Gastric Ailments in Valmalenco (Italy)

Phytochemicals and Inflammation: Is Bitter Better?

Phytoestrogens and Health Effects

Contact Info

Product

Resources

About