Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells

Groh, Isabel Anna Maria; Chen, Chen; Lüske, Claudia; Cartus, Alexander; Esselen, Melanie

doi:10.1155/2013/821082

Cited by 43 publications

(32 citation statements)

References 58 publications

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“…Pieces of evidence have been obtained that diet and environmental factors directly or indirectly influence epigenetic mechanisms associated with colon cancer development. The inhibition of histone deacetylase (HDAC) activity and the disruption of the HDAC complex are some of the basic mechanisms involved [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Kumar¹,

Hemalatha²,

Kumar³

et al. 2013

Med Epigenet

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Colorectal cancer (CRC) is a common epithelial neoplasia across the globe, with about 1.2 million newly diagnosed cases and over 600,000 mortalities annually. The underlying causes are numerous including dietary ingredients, environmental factors and gut metabolome that affect colon cellular gene regulation and post-translational modifications of the proteome. Collectively, these alterations initiate epigenetic modifications leading to the inception of various metabolic diseases and malignancies. Epigenetics is at the core of modern medicine since it deals with complex processes that turn the expression of certain genes on and off, and it elucidates the mechanisms and connections between genotypes and the environment during various stages of life. However, the majority of the vertical molecular mechanisms with reference to epigenomics, epigenetic and metabolic ailments are still unidentified and need further research. This article summarizes the burgeoning role of probiotic metabolites and some prominent therapeutic dietary ingredients in the management of CRC.

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Section: Introductionmentioning

confidence: 99%

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Kumar¹,

Hemalatha²,

Kumar³

et al. 2013

Med Epigenet

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“…74 Genistein, an epigallocatechin 3-gallate herbal alkenylbenzene methyleugenol-derived oxidative metabolite, efficiently exerted inhibitory effects on HDAC1 activity. 75 Genistein was also reported to induce expression of DKK1 by acetylation of histone H3 at the DKK1 promoter region in HCT15 and SW480 cells. However, DNA methylation at the promoter region of DKK1 was not modulated by genistein in colon cancer cells.…”

Section: Hdac Inhibitorsmentioning

confidence: 98%

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers

Farooqı¹,

Tang²,

Li³

et al. 2015

IJN

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Research concerning the epigenome over the years has systematically and sequentially shown substantial development and we have moved from global inhibition of modifications of the epigenome toward identification and targeted therapy against tumor-specific epigenetic mechanisms. In accordance with this approach, several drugs with epigenetically modulating activity have received considerable attention and appreciation, and recently emerging scientific evidence is uncovering details of their mode of action. High-throughput technologies have considerably improved our existing understanding of tumor suppressors, oncogenes, and signaling pathways that are key drivers of cancer. In this review, we summarize the general epigenetic mechanisms in cancer, including: the post-translational modification of DNA methyltransferase and its mediated inactivation of Ras association domain family 1 isoform A, Sonic hedgehog signaling, Wnt signaling, Notch signaling, transforming growth factor signaling, and natural products with epigenetic modification ability. Moreover, we introduce the importance of nanomedicine for delivery of natural products with modulating ability to epigenetic machinery in cancer cells. Such in-depth and comprehensive knowledge regarding epigenetic dysregulation will be helpful in the upcoming era of molecular genomic pathology for both detection and treatment of cancer. Epigenetic information will also be helpful when nanotherapy is used for epigenetic modification.

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“…Long-term genistein treatment of MCF-7 breast cancer cell line reduced the acetylation of H3 and altered growth responses to mitogens and HDAC inhibitors (Jawaid et al 2010). In colon tumor HT29 cells, combined therapy of EGCG and genistein inhibited HDACs activity (Groh et al 2013). Genistein treated in breast cancer cell lines MDA-MB-231 and BT20 resulted in an increased kinase activity, accompanied by histone phosphorylation, transcriptional activation, and G2/M arrest (Cappelletti et al 2000).…”

Section: Isoflavonoidsmentioning

confidence: 99%

Epigenetic Impact of Bioactive Dietary Compounds in Cancer Chemoprevention

Šupić

Wagner

Magić

2016

Critical Dietary Factors in Cancer Chemoprevention

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Epigenetic changes refer to modifications caused by heritable but potentially reversible changes in gene expression not coded in the DNA sequence. Evidence has been provided that various environmental factors and dietary bioactive compounds contribute to cancer development through epigenetic mechanisms. The main mechanisms of epigenetic control in mammals are DNA methylation, histone modifications, and RNA silencing through noncoding RNAs. The inhibition of DNA methyltransferases (DNMTs) involved in DNA methylation of CpG-rich regions of gene promoters and various enzymes involved in the chromatin condensation such as histone deacetylases (HDACs) have been recognized as potent strategies for cancer therapy and chemoprevention. Treatments using natural compounds such as green tea polyphenols, soy isoflavones, curcumin, resveratrol, isothiocyanates, and butyrate (an intestinal product from dietary fiber) modulate DNMT or HDAC gene expression and/or protein levels and activities, indicating that natural compounds could have strong potential to reverse epigenetic changes, without the adverse toxic effects associated with synthetic epigenetic inhibitors used in chemotherapy. Further characterization of the chemopreventive properties of various dietary bioactive compounds is warranted to potentially establish the clinical utility of dietary factors as anticancer compounds either alone or in combination with other dietary factors or clinically relevant therapeutics. Moreover, these characterizations are useful for personalized dietary recommendations and chemopreventive strategies for reducing cancer incidence.

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Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells

Cited by 43 publications

References 58 publications

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers

Epigenetic Impact of Bioactive Dietary Compounds in Cancer Chemoprevention

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