Plant Poisonings: Common Plants that Contain Cardiac Glycosides

Oerther, Sarah

doi:10.1016/j.jen.2010.09.008

Cited by 16 publications

(9 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This commonly known as lady's glove, purple foxglove or common foxglove, it belongs to family Scrophulariaceae (Singh et al, 2006) and possess significant cardenolides. The amount of cardenolides digitoxigenin and gitoxigenin was found to be 11.34 and 240.59 mg/kg, respectively in 2 years old plant (Oerther et al, 2011;Usai et al, 2007) and gitoxin and digitoxin were estimated to be 0.1453 and 0.0820 mg, respectively per 100 g of dry leaf powder by micro-high performance liquid chromatography (MHPLC) analysis (Fujii et al, 1983). The extracts of gitoxin and its derivatives (digitalinum verum and stropeside) from its leaves showed positive inotropic and chronotropic effects at the dose range of 20 to 40 µg/ml.…”

Section: Digitalis Purpureamentioning

confidence: 91%

“…It was used in 1785 for dropsy and other diseases. Recently in Denmark, different preparations were made from leaves of this plant and were used as powder in tinctures, infusions, tablets to test activity of cardiac glycosides present in it (Norn et al, 2004;Oerther et al, 2011). It provided positive inotropic support by maintaining a balance of sodium and potassium ions inside the cells (Maureen et al, 2009).…”

Section: Digitalis Lanatamentioning

confidence: 99%

“…Strophanthus of family Apocynaceae is a genus of 35 to 40 species of plants known for possessing cardenolides with varying morphology (Kawaguchi et al, 1993;Oerther et al, 2011). Cardenolides have been identified from many of its species.…”

Section: Strophanthus Gratusmentioning

confidence: 99%

See 2 more Smart Citations

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

Altaf¹

2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Herbal medicines are being centrally focused since ages for the screening of newer and better treatment of health problems especially cardiac diseases. In the current manuscript, we have reviewed a number of important constituents of different herbs and plants, which belong to a wide range of families that affect the cardiovascular system by acting through one mechanism or the other as Rauwolfia serpentine, Nigella sativa, Curcuma longa and Allium sativum. However, there is an evidence for a considerable number of plants such as Phaleria macrocarpa, Inula racemosa, Panax notoginseng etc., that contain constituents affecting the cardiovascular system and can be beneficial for cardiac problems, but still need further investigation and pharmacological evaluation.

show abstract

Section: Digitalis Purpureamentioning

confidence: 91%

Section: Digitalis Lanatamentioning

confidence: 99%

See 1 more Smart Citation

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

Altaf¹

2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Strophanthidin, cymarin, cynocannoside, helveticoside, apobioside, apocannoside, cannogenol [26] As is obvious from Table 1, CGs are produced by many different plants, some of which are either common household plants (e.g., Nerium oleander) [27,28] or can be mistaken for other herbs [29,30], thus, increasing the risk of accidental, or even purposeful CG poisoning. All the aforementioned CGs belong to the so-called cardenolides, which are, with few exceptions, produced exclusively by plants.…”

Section: Cardiac Glycoside Referencementioning

confidence: 99%

Quo vadis Cardiac Glycoside Research?

Bejček

Jurášek

Spiwok

et al. 2021

Toxins

View full text Add to dashboard Cite

Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation. Interestingly, some insect species can take advantage of the CG’s toxicity and by absorbing them, they are also protected from predation. The mechanism of action of CG´s toxicity is inhibition of Na+/K+-ATPase (the sodium-potassium pump, NKA), which disrupts the ionic homeostasis leading to elevated Ca2+ concentration resulting in cell death. Thus, NKA serves as a molecular target for CGs (although it is not the only one) and even though CGs are toxic for humans and some animals, they can also be used as remedies for various diseases, such as cardiovascular ones, and possibly cancer. Although the anticancer mechanism of CGs has not been fully elucidated, yet, it is thought to be connected with the second role of NKA being a receptor that can induce several cell signaling cascades and even serve as a growth factor and, thus, inhibit cancer cell proliferation at low nontoxic concentrations. These growth inhibitory effects are often observed only in cancer cells, thereby, offering a possibility for CGs to be repositioned for cancer treatment serving not only as chemotherapeutic agents but also as immunogenic cell death triggers. Therefore, here, we report on CG´s chemical structures, production optimization, and biological activity with possible use in cancer therapy, as well as, discuss their antiviral potential which was discovered quite recently. Special attention has been devoted to digitoxin, digoxin, and ouabain.

show abstract

“…It has been known that glycosides have numerous important biological functions Diederich [100]; Xue [101]. Thus, glycosides from plants are often used as pharmaceutical drugs Oerther [102]. Glycosides may also be extracted from plants by ultrasoundassisted extraction method Dong [36].…”

Section: Extraction Of Glycosidesmentioning

confidence: 99%