Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

Mahmoud, Najjia N.; Carothers, Adelaide M.; Grünberger, Dezider; Bilinski, Robyn T.; Churchill, Matthew R.; Martucci, Charles; Newmark, Harold L.; Bertagnolli, Monica M.

doi:10.1093/carcin/21.5.921

Cited by 276 publications

(156 citation statements)

References 46 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…25,49 Moreover, a 64% reduction in adenoma formation in the intestine of Min-mice, which harbour genetic mutation similar to the predisposition to development of adenomatous polyposis in humans, was seen using 0.1% curcumin. 50 Taking into account the fact that rats eat approximately 5 g/day, suggests that with 0.2% curcumin in the diet an effective concentration of 10 mg/day is required for the chemopreventive properties of curcumin. The highest concentration of curcumin tested in vivo in our studies was 12.5 mg/day without signs of intestinal toxicity.…”

Section: Discussionmentioning

confidence: 99%

Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury

Land¹,

Blijlevens

Marteijn³

et al. 2003

Leukemia

View full text Add to dashboard Cite

The inhibition of nuclear factor kappa B (NF-jB) by, for instance, curcumin is becoming an important new approach in combination with chemotherapy or irradiation for the treatment of a variety of cancers including haematological malignancies. A dose-limiting side effect of anticancer therapy in the gastrointestinal tract is mucosal barrier injury. It is hypothesised that mucosal barrier injury is initiated and amplified by proinflammatory-and NF-jB-regulated mediators. Therefore, the effect of NF-jB inhibition was studied in the onset of mucosal barrier injury. In response to cytostatic drug treatment (arabinoside cytosine (Ara-C) and methotrexate (MTX)), NF-jB was activated in intestinal epithelial cells (IEC-6) resulting in an NF-jB-related induction of tumour necrosis factor alpha and monocyte chemoattractant protein-1. NF-jB inhibition increased the susceptibility of IEC-6 cells to Ara-C as well as MTX-induced cell death when obtained by the addition of caffeic acid phenethyl ester (CAPE), but not using curcumin. In an animal model for MTX-induced mucosal barrier injury, the induction of NF-jB-related cytokines and chemokines was detected upon treatment with MTX. Despite increased susceptibility shown in vitro, the inhibition of NF-jB resulted in a partial amelioration of villous atrophy normally seen in the small intestine upon MTX treatment. These results show that the inhibition of NF-jB does not increase intestinal side effects of the anticancer treatment, suggesting a safe use of curcumin and CAPE in combination with anticancer treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury

Land¹,

Blijlevens

Marteijn³

et al. 2003

Leukemia

View full text Add to dashboard Cite

show abstract

“…another group investigated curcumin's ability to prevent tumors in C57BL/6J-Min/+ (Min/+) mice that bear a germline mutation in the APC gene and spontaneously develop numerous intestinal adenomas by 15 weeks of age [127]. The data obtained in that study were corroborated by a later study of the effects of curcumin on apoptosis and tumorigenesis in male apc (min) mice treated with the human dietary carcinogen 2-amino 1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) [92].…”

Section: Curcumin Is a Potent Chemopreventive Agentmentioning

confidence: 99%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,910

1,290

View full text Add to dashboard Cite

“…The Apc Min mouse is a model of gastrointestinal carcinogenesis genetically driven by a truncating Apc gene mutation (Luongo et al, 1994), and it resembles the human heritable condition, familial adenomatous polyposis coli (FAP). Among diet-derived agents that have been found to impede carcinogenesis in these models are tea preparations, which interfered with carcinogenesis in TRAMP (Gupta et al, 2001) and TAg mice (Kaur, Greaves, Cooke, Edwards, Steward, Gescher and Marczylo, submitted), and the yellow spice curcumin, which compromised adenoma development in Apc Min mice (Mahmoud et al, 2000;Perkins et al, 2002). In the light of the putative health benefit, which might be derived from rice bran, we tested the hypothesis that its consumption interferes with breast, prostate or intestinal carcinogenesis in the TAg, TRAMP or Apc Min mouse models.…”

mentioning

confidence: 99%

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

et al. 2007

View full text Add to dashboard Cite

Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or Apc Min mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in Apc Min mice by 51% (Po0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard Apc Min adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.

show abstract

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

Cited by 276 publications

References 46 publications

Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury

Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury

Curcumin as “Curecumin”: From kitchen to clinic

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

Contact Info

Product

Resources

About