Plant phenolic compounds and oxidative stress: integrated signals in fungal–plant interactions

Shalaby, Samer; Horwitz, Benjamin A.

doi:10.1007/s00294-014-0458-6

Cited by 123 publications

(82 citation statements)

References 71 publications

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“…Significantly enriched GO category xenobiotic metabolic processes (GO:0006805) also represented a catechol 1,2-dioxygenase gene, sscle_04g037100, involved in detoxification of host phenolic compounds. Catechol dioxygenases are induced in response to the phenolics produced by host plants [58]. The catechol dioxygenase gene CCHD1 was induced by maize phenolics [59], and was shown to be a virulence factor in the spruce pathogen Endoconidiophora polonica [60].…”

Section: Detoxification Of Xenobiotic Compoundsmentioning

confidence: 99%

Transcriptome analysis of the plant pathogen Sclerotinia sclerotiorum interaction with resistant and susceptible canola (Brassica napus) lines

et al. 2020

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Sclerotinia stem rot is an economically important disease of canola (Brassica napus) and is caused by the fungal pathogen Sclerotinia sclerotiorum. This study evaluated the differential gene expression patterns of S. sclerotiorum during disease development on two canola lines differing in susceptibility to this pathogen. Sequencing of the mRNA libraries derived from inoculated petioles and mycelium grown on liquid medium generated approximately 164 million Illumina reads, including 95 million 75-bp-single reads, and 69 million 50-bp-paired end reads. Overall, 36% of the quality filter-passed reads were mapped to the S. sclerotiorum reference genome. On the susceptible line, 1301 and 1214 S. sclerotiorum genes were differentially expressed at early (8-16 hours post inoculation (hpi)) and late (24-48 hpi) infection stages, respectively, while on the resistant line, 1311 and 1335 genes were differentially expressed at these stages, respectively. Gene ontology (GO) categories associated with cell wall degradation, detoxification of host metabolites, peroxisome related activities like fatty acid ß-oxidation, glyoxylate cycle, oxidoreductase activity were significantly enriched in the up-regulated gene sets on both susceptible and resistant lines. Quantitative RT-PCR of six selected DEGs further validated the RNA-seq differential gene expression analysis. The regulation of effector genes involved in host defense suppression or evasion during the early infection stage, and the expression of effectors involved in host cell death in the late stage of infection provide supporting evidence for a two-phase infection model involving a brief biotrophic phase during early stages of infection. The findings from this study emphasize the role of peroxisome related pathways along with cell wall degradation and detoxification of host metabolites as the key mechanisms underlying pathogenesis of S. sclerotiorum on B. napus.

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Section: Detoxification Of Xenobiotic Compoundsmentioning

confidence: 99%

Transcriptome analysis of the plant pathogen Sclerotinia sclerotiorum interaction with resistant and susceptible canola (Brassica napus) lines

et al. 2020

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“…To further colonize hosts and establish disease, fungal pathogens deploy a plethora of virulence factors (e.g., PeCRT and PeSAT) [6,7,21]. Some virulence factors are upregulated to facilitate effective host colonization and infection [28,29]. For example, the fungal plant pathogen Mycosphaerella graminicola strongly upregulates the expression of Mg3LysM and Mg1LysM genes [30].…”

Section: Introductionmentioning

confidence: 99%

The Pattern and Function of DNA Methylation in Fungal Plant Pathogens

Zhang

et al. 2020

Microorganisms

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To successfully infect plants and trigger disease, fungal plant pathogens use various strategies that are dependent on characteristics of their biology and genomes. Although pathogenic fungi are different from animals and plants in the genomic heritability, sequence feature, and epigenetic modification, an increasing number of phytopathogenic fungi have been demonstrated to share DNA methyltransferases (MTases) responsible for DNA methylation with animals and plants. Fungal plant pathogens predominantly possess four types of DNA MTase homologs, including DIM-2, DNMT1, DNMT5, and RID. Numerous studies have indicated that DNA methylation in phytopathogenic fungi mainly distributes in transposable elements (TEs), gene promoter regions, and the repetitive DNA sequences. As an important and heritable epigenetic modification, DNA methylation is associated with silencing of gene expression and transposon, and it is responsible for a wide range of biological phenomena in fungi. This review highlights the relevant reports and insights into the important roles of DNA methylation in the modulation of development, pathogenicity, and secondary metabolism of fungal plant pathogens. Recent evidences prove that there are massive links between DNA and histone methylation in fungi, and they commonly regulate fungal development and mycotoxin biosynthesis.

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“…Phenolic compounds are involved in biochemical and structural plant defence mechanisms against pathogens, functioning either as signalling molecules, antioxidants, cell wall reinforcements and/or antimicrobials (Lattanzio et al ., ; Shalaby & Horwitz, ). Therefore, the aim of this study was to investigate whether treatment of wheat with Si could reduce the infection rate by P .…”

Section: Introductionmentioning

confidence: 99%

Wheat leaf resistance to Pyrenophora tritici‐repentis induced by silicon activation of phenylpropanoid metabolism

et al. 2018

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Tan spot caused by Pyrenophora tritici-repentis is a disease present in all wheat-producing countries and silicon (Si) treatment of wheat plants has been shown to increase plant resistance to tan spot. In this study, the effect of phenylpropanoid metabolism on resistance to tan spot was evaluated and some phenolic compounds that accumulated in response to P. tritici-repentis attack were identified. Furthermore, the effect of Si on phenylalanine ammonia-lyase (PAL) activity and phenolic compound accumulation were determined in situ. Antifungal activity of differentially accumulated phenolic compounds was also evaluated in in vitro tests. Results showed that the increase in concentration of phenolic compounds was greatest at the onset of infection, and that some compounds showed fungitoxic effects including fungal tip swelling, granulation of germ tube and hyphae, and hyphal hyperbranching. Silicon-induced reduction in both lesion size and tan spot disease progression were associated with activation of phenylpropanoid metabolism. PAL activity and accumulation of antifungal phenolic compounds were greater in pathogen-inoculated plants supplied with Si. In these plants, fluorescence indicative of accumulation of phenolic compounds occurred early in epidermal cells and its intensity increased during the evaluation period, showing higher numbers of fluorescent cells around infected cells. Thus, the combined responses of cell fluorescence at sites of infection, increased PAL activity and accumulation of phenols indicate that Si strengthened wheat defence responses to infection by P. tritici-repentis, reducing the severity of tan spot.

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Plant phenolic compounds and oxidative stress: integrated signals in fungal–plant interactions

Cited by 123 publications

References 71 publications

Transcriptome analysis of the plant pathogen Sclerotinia sclerotiorum interaction with resistant and susceptible canola (Brassica napus) lines

Transcriptome analysis of the plant pathogen Sclerotinia sclerotiorum interaction with resistant and susceptible canola (Brassica napus) lines

The Pattern and Function of DNA Methylation in Fungal Plant Pathogens

Wheat leaf resistance to Pyrenophora tritici‐repentis induced by silicon activation of phenylpropanoid metabolism

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