Plant natural products with anti-thyroid cancer activity

Sharifi‐Rad, Javad; Rajabi, Sadegh; Martorell, Miquel; López, María Dolores; Toro, María; Barollo, Susi; Armanini, Decio; Fokou, Patrick Valère Tsouh; Zagotto, Giuseppe; Ribaudo, Giovanni; Pezzani, Raffaele

doi:10.1016/j.fitote.2020.104640

Cited by 20 publications

(11 citation statements)

References 124 publications

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“…Except for andrographolide, many other natural drugs have been proved to inhibit tumor progression [35,36], which indicated that phytotherapeutics were a major source of novel potential compounds useful in cancer therapy. Studies on thyroid cancer have also confirmed the anticancer activity of plant natural products both in basic research and clinical trials, suggesting that thyroid cancer may be an excellent indication for natural compounds [37]. It can be deduced from the present study that andrographolide might exert antitumor effects by inhibiting glycolysis in ATC cells.…”

Section: Discussionsupporting

confidence: 74%

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

Yang

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect. Methods. CCK8 and colony formation assays were performed to detect proliferation. Cell migration was tested by scratch assay. Annexin V/PI staining was used to detect cell apoptosis and cell cycle. Glucose and lactic acid kits were carried out to evaluate the glycolysis level after andrographolide treatment. Western blot was used to detect the changes in the apoptosis-related proteins and glycolysis-related enzymes in both 8505C and CAL62 cells. Results. Treatment with 60 μM andrographolide had significant effects on 8505C and CAL62, including inhibition of proliferation, inhibition of migration, arrest of the cell cycle, promotion of apoptosis, and inhibition of glycolysis. Conclusion. Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells.

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Section: Discussionsupporting

confidence: 74%

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

Yang

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…More recently, artesunate has been selected for a Phase III study in COVID-19 patients, essentially based on its anti-inflammatory, rather than virucidal, properties (WHO Solidarity Trial, https://www.isrctn.com/ISRCTN18066414, accessed on 15 September 2021). Curcumin is a well-known bioactive natural product that acts against different targets [30][31][32][33]. According to virtual screening, it has the potential of targeting the ACE2-RBD assembly [34].…”

Section: Antimalarial Compounds Against Sars-cov-2mentioning

confidence: 99%

A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2)

Coghi

Yang

et al. 2021

Pharmaceuticals

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Host cell invasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by the interaction of the viral spike protein (S) with human angiotensin-converting enzyme 2 (ACE2) through the receptor-binding domain (RBD). In this work, computational and experimental techniques were combined to screen antimalarial compounds from different chemical classes, with the aim of identifying small molecules interfering with the RBD-ACE2 interaction and, consequently, with cell invasion. Docking studies showed that the compounds interfere with the same region of the RBD, but different interaction patterns were noted for ACE2. Virtual screening indicated pyronaridine as the most promising RBD and ACE2 ligand, and molecular dynamics simulations confirmed the stability of the predicted complex with the RBD. Bio-layer interferometry showed that artemisone and methylene blue have a strong binding affinity for RBD (KD = 0.363 and 0.226 μM). Pyronaridine also binds RBD and ACE2 in vitro (KD = 56.8 and 51.3 μM). Overall, these three compounds inhibit the binding of RBD to ACE2 in the μM range, supporting the in silico data.

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“…Phenolic compounds are a rich source of novel prospective antithyroid cancer agents and have been shown to inhibit cell viability in several kinds of thyroid cancer cells. Although abundant preclinical studies data are existing, the clinical evidence for the potential efficacy of these herbal compounds on thyroid cancer is scarce and limited [ 32 ].…”

Section: Antioxidant Properties Of Polyphenols On Thyroid Cancermentioning

confidence: 99%

“…It has been shown to impede the development of thyroid cancer cell lines FTC-133, NPA, TPC-1, FRO, and ARO cells. Genistein can inhibit the growth of primary papillary thyroid cancer cells by exerting a protective effect against oxidative DNA damage without causing primary DNA damage [ 32 , 122 ]. Genistein can cause higher nitric oxide production and induce apoptosis.…”

Section: The Role Of Nrf2 In the Thyroidal Antioxidant Response And M...mentioning

confidence: 99%

The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer

Heydarzadeh

Kia

Zarkesh

et al. 2022

Oxidative Medicine and Cellular Longevity

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The most serious hallmark step of carcinogenesis is oxidative stress, which induces cell DNA damage. Although in normal conditions ROS are important second messengers, in pathological conditions such as cancer, due to imbalanced redox enzyme expression, oxidative stress can occur. Recent studies with firmly established evidence suggest an interdependence between oxidative stress and thyroid cancer based on thyroid hormone synthesis. Indeed, a reduced antioxidant defense system might play a part in several steps of progression in thyroid cancer. Based on studies that have been conducted previously, future drug designs for targeting enzymatic ROS sources, as a single agent or in combination, have to be tested. Polyphenols represent the potential for modulating biological events in thyroid cancer, including antioxidative activity. Targeting enzymatic ROS sources, without affecting the physiological redox state, might be an important purpose. As regards the underlying chemopreventive mechanisms of natural compounds that have been discussed in other cancer models, the confirmation of the influence of polyphenols on thyroid cancer is inconclusive and rarely available. Therefore, there is a need for further scientific investigations into the features of the antioxidative effects of polyphenols on thyroid cancer. The current review illustrates the association between some polyphenols and the key enzymes that take place in oxidation reactions in developing thyroid cancer cells. This review gives the main points of the enzymatic ROS sources act and redox signaling in normal physiological or pathological contexts and supplies a survey of the currently available modulators of TPO, LOX, NOX, DUOX, Nrf2, and LPO derived from polyphenols.

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Plant natural products with anti-thyroid cancer activity

Cited by 20 publications

References 124 publications

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2)

The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer

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