Plant Nanobionic Sensors for Arsenic Detection

Lew, Tedrick Thomas Salim; Park, Minkyung; Cui, Jianqiao; Strano, Michael S.

doi:10.1002/adma.202005683

Cited by 94 publications

(86 citation statements)

References 77 publications

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“…It is estimated that the emission of pollutants globally caused 9 million deaths in 2015 [ 127 ] and poses a significant burden on the global economy [ 128 ]. Even though a variety of efforts are underway to reduce human exposure to toxic metal species [ 129 , 130 , 131 ], their inadvertent introduction into the food chain is being increasingly recognized [ 132 ]. In addition, there is direct experimental evidence that human exposure to toxic metals adversely affects organs [ 133 ], pregnancy outcomes [ 64 ] and neurodevelopment in children [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

2021

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Globally, human exposure to environmental pollutants causes an estimated 9 million deaths per year and it could also be implicated in the etiology of diseases that do not appear to have a genetic origin. Accordingly, there is a need to gain information about the biomolecular mechanisms that causally link exposure to inorganic environmental pollutants with distinct adverse health effects. Although the analysis of blood plasma and red blood cell (RBC) cytosol can provide important biochemical information about these mechanisms, the inherent complexity of these biological matrices can make this a difficult task. In this perspective, we will examine the use of metalloentities that are present in plasma and RBC cytosol as potential exposure biomarkers to assess human exposure to inorganic pollutants. Our primary objective is to explore the principal bioinorganic processes that contribute to increased or decreased metalloprotein concentrations in plasma and/or RBC cytosol. Furthermore, we will also identify metabolites which can form in the bloodstream and contain essential as well as toxic metals for use as exposure biomarkers. While the latter metal species represent useful biomarkers for short-term exposure, endogenous plasma metalloproteins represent indicators to assess the long-term exposure of an individual to inorganic pollutants. Based on these considerations, the quantification of metalloentities in blood plasma and/or RBC cytosol is identified as a feasible research avenue to better understand the adverse health effects that are associated with chronic exposure of various human populations to inorganic pollutants. Exposure to these pollutants will likely increase as a consequence of technological advances, including the fast-growing applications of metal-based engineering nanomaterials.

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Section: Discussionmentioning

confidence: 99%

Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

2021

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“…Studies on both the positive and negative effects of nanoparticles on plants is often carried out in vivo, where one of the proposed methods of controlled application of nanoparticles to plants is foliar infiltration [ 104 ]. Leaf infiltration is also a method used to engineer plant nanobionic sensors for detection of environmental pollutants [ 105 , 106 ].…”

Section: Infiltration In Plant Nanobiotechnologymentioning

confidence: 99%

Leaf infiltration in plant science: old method, new possibilities

Chincinska

2021

Plant Methods

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The penetration of substances from the surface to deep inside plant tissues is called infiltration. Although various plant tissues may be effectively saturated with externally applied fluid, most described infiltration strategies have been developed for leaves. The infiltration process can be spontaneous (under normal atmospheric pressure) or forced by a pressure difference generated between the lamina surface and the inside of the leaf. Spontaneous infiltration of leaf laminae is possible with the use of liquids with sufficiently low surface tension. Forced infiltration is most commonly performed using needle-less syringes or vacuum pumps.Leaf infiltration is widely used in plant sciences for both research and application purposes, usually as a starting technique to obtain plant material for advanced experimental procedures. Leaf infiltration followed by gentle centrifugation allows to obtain the apoplastic fluid for further analyses including various omics. In studies of plant-microorganism interactions, infiltration is used for the controlled introduction of bacterial suspensions into leaf tissues or for the isolation of microorganisms inhabiting apoplastic spaces of leaves. The methods based on infiltration of target tissues allow the penetration of dyes, fixatives and other substances improving the quality of microscopic imaging. Infiltration has found a special application in plant biotechnology as a method of transient transformation with the use of Agrobacterium suspension (agroinfiltration) enabling genetic modifications of mature plant leaves, including the local induction of mutations using genome editing tools. In plant nanobiotechnology, the leaves of the target plants can be infiltrated with suitably prepared nanoparticles, which can act as light sensors or increase the plant resistance to environmental stress. In addition the infiltration has been also intensively studied due to the undesirable effects of this phenomenon in some food technology sectors, such as accidental contamination of leafy greens with pathogenic bacteria during the vacuum cooling process.This review, inspired by the growing interest of the scientists from various fields of plant science in the phenomenon of infiltration, provides the description of different infiltration methods and summarizes the recent applications of this technique in plant physiology, phytopathology and plant (nano-)biotechnology.

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“…A group of scientists from Singapore led by Dr. Lew [ 120 ] have accomplished a novel type of plant nanobionic optical sensor that can detect and monitor arsenic (in real time) in the belowground environment. Lew and co-workers have used a species of fern, Pteris cretica , which also can hyperaccumulate arsenic.…”

Section: Other Applications Of Ferns In Nano and Biotechnologymentioning

confidence: 99%

Application of Polypodiopsida Class in Nanotechnology–Potential towards Development of More Effective Bioactive Solutions

Fierăscu

Ungureanu

et al. 2021

Antioxidants

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The area of phytosynthesized nanomaterials is rapidly developing, with numerous studies being published yearly. The use of plant extracts is an alternative method to reduce the toxic potential of the nanomaterials and the interest in obtaining phytosynthesized nanoparticles is usually directed towards accessible and common plant species, ferns not being explored to their real potential in this field. The developed nanoparticles could benefit from their superior antimicrobial and antioxidant properties (compared with the nanoparticles obtained by other routes), thus proposing an important alternative against health care-associated and drug-resistant infections, as well as in other types of applications. The present review aims to summarize the explored application of ferns in nanotechnology and related areas, as well as the current bottlenecks and future perspectives, as emerging from the literature data.

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Plant Nanobionic Sensors for Arsenic Detection

Cited by 94 publications

References 77 publications

Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

Leaf infiltration in plant science: old method, new possibilities

Application of Polypodiopsida Class in Nanotechnology–Potential towards Development of More Effective Bioactive Solutions

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