Plant-Made Veterinary Vaccines for Newcastle Disease Virus

Thomas, David R.; Walmsley, Amanda Maree

doi:10.1007/978-3-319-90137-4_6

Cited by 3 publications

(1 citation statement)

References 92 publications

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“…Despite the apparent promise of oral vaccine, the major milestone regarding NDV in the history of plant-produced vaccine candidates is a purified formulation for injection: In 2006, a veterinary vaccine based on HN produced in a N. benthamiana cell culture system became the first ever plant-produced vaccine to be licensed for commercial use to protect chickens from this virus [ 171 , 172 ]. However, the owners of this technology, Dow AgroSciences, never actually commercialised it, presumably for economic reasons.…”

Section: Newcastle Disease Virusmentioning

confidence: 99%

Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult

et al. 2021

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The past 30 years have seen the growth of plant molecular farming as an approach to the production of recombinant proteins for pharmaceutical and biotechnological uses. Much of this effort has focused on producing vaccine candidates against viral diseases, including those caused by enveloped viruses. These represent a particular challenge given the difficulties associated with expressing and purifying membrane-bound proteins and achieving correct assembly. Despite this, there have been notable successes both from a biochemical and a clinical perspective, with a number of clinical trials showing great promise. This review will explore the history and current status of plant-produced vaccine candidates against enveloped viruses to date, with a particular focus on virus-like particles (VLPs), which mimic authentic virus structures but do not contain infectious genetic material.

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Section: Newcastle Disease Virusmentioning

confidence: 99%