Plant growth regulator mediated consequences of secondary metabolites in medicinal plants

Jamwal, Komal; Bhattacharya, Subhamoy; Puri, Sunil

doi:10.1016/j.jarmap.2017.12.003

Cited by 142 publications

(133 citation statements)

References 233 publications

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“…A wide range of pharmaceutical proteins for therapeutic use is currently in different phases of clinical trials [32]. It is also possible to produce secondary metabolites with high yields using routine techniques of in vitro plant cell and tissue cultures, which are becoming an attractive alternative to traditionally-used, naturally occurring plant material [33,34].…”

Section: Discussionmentioning

confidence: 99%

An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

et al. 2020

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Many biologically-active plant-derived compounds have therapeutic or chemopreventive effects. The use of plant in vitro cultures in conjunction with modern genetic engineering techniques allows greater amounts of valuable secondary metabolites to be obtained without interfering with the natural environment. This work presents the first findings concerning the acquisition of transgenic hairy roots of Senna obtusifolia overexpressing the gene encoding squalene synthase 1 from Panax ginseng (PgSS1) (SOPSS hairy loot lines) involved in terpenoid biosynthesis. Our results confirm that one of PgSS1-overexpressing hairy root line extracts (SOPSS2) possess a high cytotoxic effect against a human acute lymphoblastic leukemia (NALM6) cell line. Further analysis of the cell cycle, the expression of apoptosis-related genes (TP53, PUMA, NOXA, BAX) and the observed decrease in mitochondrial membrane potential also confirmed that the SOPSS2 hairy root extract displays the highest effects; similar results were also obtained for this extract combined with doxorubicin. The high cytotoxic activity, observed both alone or in combination with doxorubicin, may be due to the higher content of betulinic acid as determined by HPLC analysis. Our results suggest synergistic effects of tested extract (betulinic acid in greater amount) with doxorubicin which may be used in the future to develop new effective strategies of cancer chemosensitization.

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Section: Discussionmentioning

confidence: 99%

An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

et al. 2020

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“…Fargoso Monfort et al (2018) found that in Ocimum basilicum volatile constituents diminished with higher salt concentrations. Plant growth regulators can affect the production of secondary metabolites, a recent review by Jamwal et al (2018) presents a summary of the production of natural products by using different plant growth regulators.…”

Section: Improvements In Traditional Culturing Techniquesmentioning

confidence: 99%

In vitro plant tissue culture: means for production of biological active compounds

Espinosa-Leal

Puente-Garza

García‐Lara

2018

Planta

415

206

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Plant tissue culture as an important tool for the continuous production of active compounds including secondary metabolites and engineered molecules. Novel methods (gene editing, abiotic stress) can improve the technique. Humans have a long history of reliance on plants for a supply of food, shelter and, most importantly, medicine. Current-day pharmaceuticals are typically based on plant-derived metabolites, with new products being discovered constantly. Nevertheless, the consistent and uniform supply of plant pharmaceuticals has often been compromised. One alternative for the production of important plant active compounds is in vitro plant tissue culture, as it assures independence from geographical conditions by eliminating the need to rely on wild plants. Plant transformation also allows the further use of plants for the production of engineered compounds, such as vaccines and multiple pharmaceuticals. This review summarizes the important bioactive compounds currently produced by plant tissue culture and the fundamental methods and plants employed for their production.

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“…Stress provoked in the plant involves several signaling response pathways for pathogens and insects, and some of these response pathways are induced by the microorganisms themselves. Also, the plants have specific recognition and signaling systems allowing them to detect the pathogens and initiate an effective defense response [30,31]. The defence system broadest have the plants against pathogens are the phenolic compounds (phenylpropanoids and flavonoids).…”

Section: The Bioactive Potential Of Secondary Metabolites Derived Fromentioning

confidence: 99%

Plant Metabolites in Plant Defense Against Pathogens

Ramírez-Gómez¹,

Jiménez-García²,

Campos³

et al. 2020

Plant Diseases - Current Threats and Management Trends

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Medicinal plants are widely used worldwide to treat various diseases. Its widespread use is due in part to the cultural acceptance of traditional medicine in different regions of the world, as well as its effectiveness in treating various diseases. Many of its active substances or secondary metabolites are formed to a response of various situations that generate stress in their habitat, such as sudden changes in environmental temperature, humidity, rain, drought, and infections by phytopathogens (fungi, bacteria, viruses, nematodes, protozoa). The production of these secondary metabolites is a mechanism of defense of plants. In this context, the objective of this chapter is to study the secondary metabolites of medicinal plants that could have a promising application in the control of different phytopathogens in crops of agricultural and economic interest.

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Plant growth regulator mediated consequences of secondary metabolites in medicinal plants

Cited by 142 publications

References 233 publications

An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

In vitro plant tissue culture: means for production of biological active compounds

Plant Metabolites in Plant Defense Against Pathogens

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