Plant extracts and natural compounds used against UVB-induced photoaging

Cavinato, Maria; Waltenberger, Birgit; Baraldo, Giorgia; Grade, Carla Vermeulen Carvalho; Stuppner, Hermann; Jansen‐Dürr, Pidder

doi:10.1007/s10522-017-9715-7

Cited by 180 publications

(133 citation statements)

References 58 publications

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“…This flavonoid has shown anti-photoaging effects through its antioxidant and anti-inflammatory properties [49,50]. The beneficial effects have encouraged researchers to develop photo-protective products from natural sources [51]. It is known that onions, kale, lettuce, tomatoes, apples, grapes, berries, tea, and red wine are rich sources of flavonols [52].…”

Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative HPLC Analysis of Mycosporine-Like Amino Acids Extracted in Distilled Water for Cosmetical Uses in Four Rhodophyta

et al. 2019

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Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiencies of these metabolites in cosmetic compatible solvents, as well as, their subsequent HPLC analysis. In the present study, MAA extraction using distilled water and 20% aqueous methanol in four Rhodophyta was investigated. Different re-dissolution solvents and a C8 and C18 columns were tested for the HPLC analysis. Porphyra-334, shinorine, palythine, palythine-serine, asterina-330, and palythinol were identified by HPLC/ESI-MS. The separation of these MAAs were improved employing the C8-column, and using methanol as re-dissolution solvent. Regarding total MAAs concentrations, no differences between the two solvents were found. The highest MAA amounts were observed injecting them directly in the HPLC. According to these results, distilled water could be an excellent extraction solvent for MAAs. Nevertheless, the re-dissolution in pure methanol after dryness would be the best option for the qualitative analysis of the most common MAAs in these red algae. Our results entail important implications regarding the use of red macroalgae as promising candidates as environment-friendly sources of natural sunscreens. coefficients (ε = 28,100-50,000 L·mol −1 ·cm −1 ). They are secondary metabolites capable of absorbing UV radiation with the maximum absorbance between 310 and 365 nm [15][16][17]. MAAs have a general structure that consist of cyclohexenone or cyclohexenimine chromophores conjugated with one or two amino acids that are responsible of UV absorption [18]. The high photostability of MAAs over a wide range of temperature and pH, together with their antioxidant properties, make them promising metabolites in the biotechnology industry. These compounds are recognized as strong UV-absorbing molecules that can be used as an active ingredient in sun-care cosmetic products, therefore could be a potential supplement of chemical filters just used in sunscreens, also due to the fact that they could satisfy consumers who want the incorporation of natural ingredients. Additionally, MAAs could be effective against actinic erythema, but can also protect the humans against other biological effects such as immune suppression or photo-oxidative damage [11,[19][20][21][22][23][24][25]. So, MAAs are promising functional ingredients used for novel cosmeceuticals (cosmetic products with health benefits). In fact, MAAs have already been commercialized as Helioguard®365. This cosmetic reagent contains the MAAs, shinorine and porphyra-334, extracted from the red alga Porphyra umbilicalis and has been successfully commercialized as a natural and safe sunscreen compound. Nowadays, the MAA extraction protocols differ in type of solvents, temperature, and extraction times. The MAA extraction efficiencies and concentrations are affected by these conditions [26][27][28][29]. A variety of extraction and separation methods for MAAs have been...

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Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative HPLC Analysis of Mycosporine-Like Amino Acids Extracted in Distilled Water for Cosmetical Uses in Four Rhodophyta

et al. 2019

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“…Chronological aging and photoaging causes the decline in skin structure and function, resulting in the formation of wrinkles as reviewed elsewhere [14,15]. As an indicator of youth and beauty, clear unwrinkled skin is a very important part of a satisfactory appearance and quality of life, especially for Asian women [1].…”

Section: Discussionmentioning

confidence: 99%

“…* and **; p < 0.05 and p < 0.001 compared to the UVB treated control group, respectively. of senescent cells, and other effects [14]. Coarse and fine wrinkle formation in the skin is caused by deleterious alterations in the collagenous extracellular matrix and seems to be a sign of aging.…”

Section: Discussionmentioning

confidence: 99%

“…UVB is the most dangerous component of sunlight and causes DNA damage and increased oxidative stress, resulting in the appearance of wrinkles, hyperpigmentation, sallowness, and loss of skin tone, which are the main characteristics of photoaged skin [14]. Next, we investigated the effect of FAT on cell migration after UVB (30 mJ/cm 2 ) exposure.…”

Section: Wound Healing Effect Of Fatmentioning

confidence: 99%

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Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1

Park

Lee

et al. 2018

Journal of Microbiology and Biotechnology

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Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm 2) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.

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“…UV irradiation leads to DNA damage and induces oxidative stress by the production of reactive oxygen species (ROS) [2,3]. These pathways increase the synthesis and activity of proteases that degrade the extracellular matrix (ECM), which comprises collagen and elastin fibers [4]. Takeuchi et al reported that neutrophil elastase activity was increased in mouse skin following UV irradiation [5].…”

Section: Introductionmentioning

confidence: 99%

The Anti-Aging Potential of Extracts from Chaenomeles sinensis

Itoh¹,

Yamaguchi²,

Shigeyama³

et al. 2019

Cosmetics

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The Chaenomeles sinensis fruit is used as an effective antitussive agent, analgesic, and diuretic in traditional Chinese medicine. It has been reported that C. sinensis fruit extracts have antimicrobial and anti-inflammatory effects. However, there are very few reports about the effects of C. sinensis extracts on skin. In this study, we investigated the effect of C. sinensis extracts on skin aging. The results of in vitro assays showed that whole fruit extracts of C. sinensis had superoxide dismutase (SOD)-like activity and inhibited the activity of dermal extracellular matrix proteases: Elastase and collagenase. The inhibitory effect of the whole fruit (containing seeds) extract on elastase activity was higher than that of the sarcocarp (seeds removed) extract. Further, the sarcocarp extract showed a higher level of SOD-like activity and a greater inhibitory effect on collagenase activity than the whole fruit extract. In particular, among the three activities studied, the sarcocarp extract showed the most significant inhibitory effect on collagenase activity at low concentrations. The polyphenol-rich fraction obtained from the sarcocarp showed significant collagenase inhibition. Based on these results, we concluded that phenolic compounds from C. sinensis sarcocarp have the potential to protect against skin aging through anti-collagenase activity.

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Plant extracts and natural compounds used against UVB-induced photoaging

Cited by 180 publications

References 58 publications

Quantitative and Qualitative HPLC Analysis of Mycosporine-Like Amino Acids Extracted in Distilled Water for Cosmetical Uses in Four Rhodophyta

Quantitative and Qualitative HPLC Analysis of Mycosporine-Like Amino Acids Extracted in Distilled Water for Cosmetical Uses in Four Rhodophyta

Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1

The Anti-Aging Potential of Extracts from Chaenomeles sinensis

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