Plant Epigenetics: Propelling DNA Methylation Variation across the Cell Cycle

Papareddy, Ranjith; Nodine, Michael D.

doi:10.1016/j.cub.2020.11.049

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…Therefore, handing over TE silencing to CMT2-dependent CHH methylation in cells with reduced division rates likely reduces ectopic methylation of protein-coding genes. In addition to what we observed during embryogenesis, varying degrees of mitotic indices across development can readily explain the genome-wide patterns of non-CG methylation reported thus far ( Borges et al, 2021 ; Calarco et al, 2012 ; Gutzat et al, 2020 ; Ji et al, 2019 ; Kawakatsu et al, 2016 , Kawakatsu et al, 2017 ; Lin et al, 2017 ; Narsai et al, 2017 ; Papareddy and Nodine, 2021 ).…”

Section: Discussionsupporting

confidence: 70%

Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

Papareddy

Páldi

Smolka

et al. 2021

eLife

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DNA methylation has evolved to silence mutagenic transposable elements (TEs) while typically avoiding the targeting of endogenous genes. Mechanisms that prevent DNA methyltransferases from ectopically methylating genes are expected to be of prime importance during periods of dynamic cell cycle activities including plant embryogenesis. However, virtually nothing is known regarding how DNA methyltransferase activities are precisely regulated during embryogenesis to prevent the induction of potentially deleterious and mitotically stable genic epimutations. Here, we report that microRNA-mediated repression of CHROMOMETHYLASE 3 (CMT3) and the chromatin features that CMT3 prefers help prevent ectopic methylation of thousands of genes during embryogenesis that can persist for weeks afterwards. Our results are also consistent with CMT3-induced ectopic methylation of promoters or bodies of genes undergoing transcriptional activation reducing their expression. Therefore, the repression of CMT3 prevents epigenetic collateral damage on endogenous genes. We also provide a model that may help reconcile conflicting viewpoints regarding the functions of gene-body methylation that occurs in nearly all flowering plants.

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Section: Discussionsupporting

confidence: 70%

Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

Papareddy

Páldi

Smolka

et al. 2021

eLife

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“…The mobile siRNAs derived from pollen vegetative nuclei enhance the transposon methylation of the reproductive cells, resulting in TEs silencing of offspring in an epigenetic inheritance manner (Long et al, 2021). Three excellent reviews highlight how the cell cycle has influenced DNA methylation dynamics during male gametogenesis and shed light on the epigenetic regulation of cell fate (Huang and Sun, 2021;Liu and Wang, 2021;Papareddy and Nodine, 2021).…”

Section: Mitosis Of Microsporesmentioning

confidence: 99%

Male gametogenesis in flowering plants

Cui,

Xu,

Wang

et al. 2024

Front. Sustain. Food Syst.

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The life cycles of plants are characterized by significant alternations between the diploid sporophytic and the haploid gametophytic generations. Meiosis and fertilization are the prerequisites for achieving the alternation of generations. Diploid sporophytes undergo meiosis to produce haploid gametes, and male–female gametes fuse (double fertilization) to revert to the diploid sporophyte. The formation and development of male gametophytes are crucial for the alternation of generations in higher plants. During the long evolution of plants from aquatic to terrestrial, the way of sexual reproduction has undergone subversive innovations. From sperm swimming for fertilization to relying on the precise delivery of pollen tubes to female gametes for the fusion of the male–female gametes, higher requirements are placed on the male gametophytes’ development and fertilization process. The formation of male gametophytes has undergone significant changes to meet the needs for delivery and transportation of the male gametes. With the emergence of more and more evidence, the molecular mechanism underlying male gametophytes’ development, especially the initiation and specialization of germline cells has been better understood. Focusing on the latest studies, we reviewed and elucidated the critical proteins and factors involved in male gametophyte formation, highlighting the decisive role of auxin in archesporial cell specialization and the importance of microspore maturation in pre-mitosis, and analyzed the molecular mechanisms underlying male gametogenesis, with a view to providing insights for further exploration of male gametophytes formation in the future.

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“…New findings suggest that sperm cells have asymmetric mCHG, whereas vegetative nuclei and microspores possess symmetric mCHG ( Borges et al, 2021 ). DNA methylation changes during male reproductive development were recently summarized ( Papareddy and Nodine, 2021 ).…”

Section: Epigenetic Regulation Of Heat Stress During Male Reproductionmentioning

confidence: 99%

Epigenetic Regulation of Heat Stress in Plant Male Reproduction

Malik

Zhao

2022

Front. Plant Sci.

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In flowering plants, male reproductive development is highly susceptible to heat stress. In this mini-review, we summarized different anomalies in tapetum, microspores, and pollen grains during anther development under heat stress. We then discussed how epigenetic control, particularly DNA methylation, is employed to cope with heat stress in male reproduction. Further understanding of epigenetic mechanisms by which plants manage heat stress during male reproduction will provide new genetic engineering and molecular breeding tools for generating heat-resistant crops.

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Plant Epigenetics: Propelling DNA Methylation Variation across the Cell Cycle

Cited by 8 publications

References 21 publications

Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

Male gametogenesis in flowering plants

Epigenetic Regulation of Heat Stress in Plant Male Reproduction

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