Plant-Derived Natural Products: A Source for Drug Discovery and Development

Abstract

For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the design, discovery, and development of new drugs. With the invention of recent molecular targets based on proteins, there is a growing need for fresh chemical diversification in screening. Natural products will play a vital part in supplying this need via the continuous exploration of global biodiversity, the majority of which remains unexplored. Even though drug discovery from medicinal plants remains an important source of novel therapeutic leads, various hurdles exist, including identifying and executing suitable high-throughput screening bioassays, scaling up the supply of bioactive molecules, and acquiring plant materials. Investigating these natural resources takes multi-disciplinary, nationwide, and global partnerships in design, synthesis, discovery, and drug development techniques. This review article discusses current advancements and future approaches for discovering natural items such as health- and wellness-promoting remedies. It also summarizes strategies to unify the therapeutic use of plant-derived natural products worldwide to support future drug discoveries derived from plant sources.

A comprehensive investigation on alleviating oxidative stress and inflammation in hyperglycaemic conditions through in vitro experiments and computational analysis

“…Plant-based pharmaceutical approaches provide a safe, efficient, and economical substitute for traditional methods involving animal cell cultures or microbial fermentation in the drug-development process. Consequently, pharmaceuticals made from plant-based natural chemicals can provide patients with more rapid and easier access to treatment ( Chaachouay and Zidane, 2024 ).…”

Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of <em>Oregano </em>(<em>Origanum vulgare</em>) and <em>Salvia triloba</em> Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

“…Developing novel strategies to combat antibiotic resistance is now paramount [21]. Under these dire perspectives, plant extracts are recognized as a unique and valuable source of natural substances useful for drug discovery and advancement [20,28,29]. In the present research, we focus on the in vitro biological evaluation of the extracts of two plants: Origanum vulgare (O. vulgare) obtained from the mountainous regions of Epirus, Greece, and Salvia triloba (S. triloba), commonly known as Greek sage, originating from the island of Crete, Greece.…”

Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

“…Phytochemical research is expected to reveal undiscovered biomolecules from which pioneering remedies could develop [19][20][21]. This expectation becomes especially relevant as the threat of antibiotic resistance posed by pathogenic bacteria escalates significantly each year [22][23][24][25][26].…”

“…It is also true that the pharmaceutical industry faces serious economical, regulatory, and scientific difficulties to develop new classes of antibiotics [27]. Developing novel strategies to combat antibiotic resistance is now paramount [14,20]. Under these dire perspectives, plant extracts are recognized as a unique and valuable source of natural substances useful for drug discovery and advancement [20,28,29].…”

“…Developing novel strategies to combat antibiotic resistance is now paramount [14,20]. Under these dire perspectives, plant extracts are recognized as a unique and valuable source of natural substances useful for drug discovery and advancement [20,28,29]. In the present research, we focus on the in vitro biological evaluation of the extracts of two plants: Origanum vulgare (O. vulgare) obtained from the mountainous regions of Epirus, Greece, and Salvia triloba (S. triloba), commonly known as Greek sage, originating from the island of Crete, Greece.…”