Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms

Asghar, Sajid; Khan, Ikram Ullah; Salman, Saad; Khalid, Syed Haroon; Ashfaq, Rabia; Vandamme, Thierry F.

doi:10.1016/j.addr.2021.114019

Cited by 10 publications

(3 citation statements)

References 588 publications

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“…In addition, the presence of surfactant in the film could also have helped the Cur in penetrating the bacterial cell walls. The increased antimicrobial activity against S. aureus compared to E. coli might originate from the differences in bacterial cell wall structure of both species, as the complex cell wall of Gram-negative bacteria obstructs the drug entry into the bacteria more efficiently than Gram-positive bacteria . Nonetheless, PGC4 could be used as an effective material for wounds not only by restricting access of the microbes to the wound bed but also due to its ability to kill them.…”

Section: Resultsmentioning

confidence: 99%

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

et al. 2023

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Curcumin (Cur) entrapped poly(vinyl alcohol) (PVA)/gelatin composite films were prepared by cross-linking with tannic acid (TA) as bioactive dressings for rapid wound closure. Films were evaluated for mechanical strength, swelling index, water vapor transmission rate (WVTR), film solubility, and in-vitro drug release studies. SEM revealed uniform and smooth surfaces of blank (PG9) and Cur-loaded composite films (PGC4). PGC4 exhibited excellent mechanical strength (tensile strength (TS) and Young’s modulus (YM) were 32.83 and 0.55 MPa, respectively), swelling ability (600–800% at pH 5.4, 7.4, and 9), WVTR (2003 ± 26), and film solubility (27.06 ± 2.0). Sustained release (81%) of the encapsulated payload was also observed for 72 h. The antioxidant activity determined by DPPH free radical scavenging showed that the PGC4 possessed strong % inhibition. The PGC4 formulation displayed higher antibacterial potential against S. aureus (14.55 mm zone of inhibition) and E. coli (13.00 mm zone of inhibition) compared to blank and positive control by the agar well diffusion method. An in-vivo wound healing study was carried out on rats using a full-thickness excisional wound model. Wounds treated with PGC4 showed very rapid healing about 93% in just 10 days post wounding as compared to 82.75% by Cur cream and 80.90% by PG9. Furthermore, histopathological studies showed ordered collagen deposition and angiogenesis along with fibroblast formation. PGC4 also exerted a strong anti-inflammatory effect by downregulating the expression of pro-inflammatory cytokines (TNF-α and IL-6 were lowered by 76% and 68% as compared to the untreated group, respectively). Therefore, Cur-loaded composite films can be an ideal delivery system for effective wound healing.

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Section: Resultsmentioning

confidence: 99%

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

et al. 2023

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“…coli and permit the entrance of water absorbent compounds while serving as a barrier to lipophilic substances and limiting the chemical entry via size . As a result, it is reasonable to predict that solubilizing lipophilic antibacterial substances in ME systems will increase the number of binding sites that can interface with porins . Recent research publications have reported an increase in the antibacterial activity of NE, including EOs such as thyme oil and cinnamon, rosemary, oregano, etc .…”

Section: Resultsmentioning

confidence: 99%

“…46 As a result, it is reasonable to predict that solubilizing lipophilic antibacterial substances in ME systems will increase the number of binding sites that can interface with porins. 47 Recent research publications have reported an increase in the antibacterial activity of NE, including EOs such as thyme oil and cinnamon, rosemary, oregano, etc. 48 Furthermore, the findings of this investigation revealed that the antibacterial activity of MEs was significantly more effective.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Nanosizing of Lavender, Basil, and Clove Essential Oils into Microemulsions for Enhanced Antioxidant Potential and Antibacterial and Antibiofilm Activities

Manzoor,

Asif,

Khalid

et al. 2023

ACS Omega

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Plant essential oils (EOs) possess significant bioactivities (antibacterial and antioxidant) and can be substituted for potentially harmful synthetic preservatives in the food industry. However, limited water solubility, bioavailability, volatility, and stability limit their use. Therefore, the goal of this research was nanosizing lavender essential oil (LEO), basil essential oil (BEO), and clove essential oil (CEO) in a microemulsion (ME) to improve their physicochemical attributes and bioefficacy. Tween 80 and Transcutol P were utilized for construction of pseudoternary phase diagrams. It was observed that the concentration of EOs had a great impact on the physicochemical and biological properties of MEs. A spherical droplet of MEs with a diameter of less than 20 nm with a narrower size distribution (polydispersity index (PDI) = 0.10−0.27) and a ζ potential of −0.27 to −9.03 was observed. ME formulations were also evaluated for viscosity, conductivity, and the refractive index. Moreover, the impact of delivery systems on the antibacterial property of EOs was assessed by determining the zone of inhibition and minimum inhibitory concentration against two distinct pathogen classes (S. aureus and E. coli). Crystal violet assay was used to measure the growth and development of biofilms. According to bioefficacy assays, ME demonstrated more efficient antibacterial activity against microorganisms at concentrations lower than pure EOs. CEO ME had superior activity againstS. aureus and E. coli. Similarly, dosedependent antioxidant capacity was noted for MEs. Consequently, nanosized EO formulations with improved physicochemical properties and enhanced bioactivities can be employed in the food processing sector as a preservation agent.

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Preface: Phyto-derived nanomedicines for therapeutics, imaging and drug delivery

Qiao

Zhang

Cheng

2023

Advanced Drug Delivery Reviews

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Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms

Cited by 10 publications

References 588 publications

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

Nanosizing of Lavender, Basil, and Clove Essential Oils into Microemulsions for Enhanced Antioxidant Potential and Antibacterial and Antibiofilm Activities

Preface: Phyto-derived nanomedicines for therapeutics, imaging and drug delivery

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