Plant-derived nanoparticles and plant virus nanoparticles: Bioactivity, health management, and delivery potential

Liu, Cun; Fang, Liguang; Wang, Jia; Sun, Chunjie; Li, Huayao; Zhuang, Jing; Sun, Changgang

doi:10.1080/10408398.2023.2204375

Cited by 4 publications

(3 citation statements)

References 140 publications

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Section: Discussionmentioning

confidence: 54%

“…Increasing evidence reveals that oral administration of edible plants-derived exosome-like nanoparticles show high stability in the digestive system and potent preventive effects against intestinal disease. 28 Here, we found that oral BENs at a dosage of 17.5 mg/kg•d, passing through the upper digestive tract and entering the colonic sites, suppressed LOP-induced constipation phenotypes including shortened defecation time, accelerated intestinal ink propulsion rate, and increased the amount of feces (Figures 2 and 3). At the same time, BENs regulated the production of gastric regulatory peptides in LOP-induced constipated mice, with increased levels of excitatory peptides (SP and MTL) and decreased levels of inhibitory peptides (VIP and ET-1) in the serum and the colon.…”

Section: Discussionmentioning

confidence: 70%

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Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism

Duan,

Wang,

Dong

et al. 2023

J. Agric. Food Chem.

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Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency and side effects. Here, we demonstrated that broccoli-derived exosome-like nanoparticles (BENs), a natural product with high gastrointestinal stability, ameliorated LOP-induced constipation in mice. Specifically, orally administered BENs (17.5 mg/kg/d) effectively shortened defecation time, sped up intestinal propulsion rate, and increased feces amount in constipated mice. BENs also raised excitatory neurotransmitters SP and MTL and reduced inhibitory neurotransmitters VIP and ET-1. Mechanistically, BENs were taken up by gut microbes, restored LOP-disordered gut microbiota, and altered microbial metabolism of SCFAs and tryptophan, as evidenced by the results of fluorescence microscopy, 16S rRNA gene sequencing, and nontargeted metabolomics. Thereinto, BEN-enriched SCFA-producing microorganisms are closely associated with the feces amount and SP and VIP levels and BEN-elevated indole-3-pyruvic acid and 3-indoleacetic acid are highly linked to ET-1, SP, and MTL levels. Conclusively, BENs, mitigating constipation by regulating gut microbiota and microbial tryptophan metabolism, showed high potential to be developed as alternative regimens for constipation.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 70%

Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism

Duan,

Wang,

Dong

et al. 2023

J. Agric. Food Chem.

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“…In addition, nanotechnology-based drug delivery systems have emerged as an attractive strategy. Compared to MEVs and synthetic nanoparticles, PELNs are non-toxic properties, low immunogenicity, high bioavailability, and easy absorption, which helps to solve the poor bioavailability of many active ingredients ( 31 ). Although these superior characteristics of PELNs have been reviewed in previous publications ( 11 , 20 , 22 , 25 , 32 ), there are still many issues for researchers to refine and investigate.…”

Section: Introductionmentioning

confidence: 99%

Ginger: a representative material of herb-derived exosome-like nanoparticles

Zhu

2023

Front. Nutr.

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Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within the plant kingdom. Recently, a number of herbaceous sources have been investigated for the isolation and functionality of exosome-like nanoparticles (ELNs). However, they are commonly referred to as PELNs, and their distinct pharmacological properties are overlooked. In this review, these herb-derived ELNs are designated as HELNs, a novel herbal product that may also exhibit superior pharmacological activity compared to other types of PELNs. Among the documented HELNs, ginger-derived exosome-like nanoparticles (GELNs) are the most extensively studied. This review employs GELNs as an exemplar to delineate the process of extraction and purification, together with their physical and biochemical characteristics and therapeutic potential. The aim of this review is to promote the development and application of HELNs, and future research is encouraged to uncover their additional properties, extending beyond those of GELNs.

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Plant-derived exosome-like nanoparticles – from Laboratory to factory, a landscape of application, challenges and prospects

Wei,

Zhang,

Cheng

et al. 2024

Critical Reviews in Food Science and Nutrition

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Plant-derived nanoparticles and plant virus nanoparticles: Bioactivity, health management, and delivery potential

Cited by 4 publications

References 140 publications

Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism

Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism

Ginger: a representative material of herb-derived exosome-like nanoparticles

Plant-derived exosome-like nanoparticles – from Laboratory to factory, a landscape of application, challenges and prospects

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