Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms

Bina, Fatemeh; Soleymani, Samaneh; Toliat, Tayebeh; Hajimahmoodi, Mannan; Tabarrai, Malihe; Abdollahi, Mohammad; Rahimi, Roja

doi:10.1016/j.phrs.2018.11.008

Cited by 46 publications

(38 citation statements)

References 136 publications

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“…Endometriosis is a common inflammatory disease often accompanied by pelvic pain and infertility. Generally, surgeries are conducted to treat endometriosis, but accumulating evidence suggest the use of plant-based drugs for the treatment, and these medicines usually alleviate the symptoms via their anti-inflammatory, anti-oxidant, anti-proliferation, and anti-apoptotic effects ( Audebert, 2018 ; Falcone and Flyckt-Rebecca, 2018 ; Bina et al, 2019 ). Ovarian cancer and breast cancer are the top two cancers in women ( Anastasiadi et al, 2017 ; Stewart et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

175

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Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of C. asiatica and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascular diseases, gastrointestinal diseases, immune diseases, and gynecological diseases, as well as potential molecular mechanisms, to study the pathological mechanism of these diseases based on the changes at the molecular level. The results showed that C. asiatica and its triterpenoids had extensive beneficial effects on neurological and skin diseases, which were confirmed through clinical studies. They exhibited anti-inflammatory, antioxidative stress, anti-apoptotic effects, and improvement in mitochondrial function. However, further clinical studies are urgently required due to the low level of evidence and lack of patients.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

175

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“…Bcl-2 is a well-known regulator inhibiting cellular apoptosis, while Bax and Bad trigger the cascades leading to apoptosis. Downstream caspase-9 causes activation of caspase-3, which induces PARP to cleavage PARP [44]. In this study, JFS elevated apoptosis of ectopic endometrium using the TUNEL assay in the EMS rat model.…”

Section: Discussionmentioning

confidence: 91%

Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence

Jiang

Zhao

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine. Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms. To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction. Molecular docking and validation in vivo were investigated by the proapoptotic mechanisms of JFS. In this study, 99 common targets were related to 108 diseases. 484 biological processes, 44 cell components, 59 molecular functions, and 37 pathways were significantly identified in GO enrichment and pathway analysis. In molecular docking, ligustrazine showed binding activity with Bcl-2, Bax, caspase-9, caspase-3, and PARP. In vivo, JFS elevated the shrink rate of ectopic endometrium, by suppressing E2 and PROG. An in-depth study showed that apoptosis was activated through diminishing Bcl-2, rising Bax and Bad, and expressing more caspase-3 and caspase-9 using JFS. JFS promoted the protein level of cleaved-PARP. In brief, JFS might be applied for various diseases through multiple targets and pathways, especially endometriosis by Bcl-2 pathway. These findings reveal the potential application for further evaluation and uncover the proapoptotic mechanism of JFS.

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“…Ademais, a cefaleia, pele ressecada, infecção, dores, gripes e resfriados, também são sintomas bastante comuns nesse período e criam um incômodo aparente. No que tange aos fitoterápicos utilizados, destacaram-se o limão, a gengibre e a hortelã, para quadros gripais, os quais são muito utilizados durante a gravidez no 1º e 2º trimestre (Kissal, Güner & Ertürk, 2017), assim como, o manjericão, capim-santo e o pinheiro-bravo para dores e cefaleia (Nega, Bekele, Meles & Nordeng, 2019;Bina et al, 2019;Yemele et al, 2015) e a prímula, indicada para pele ressecada (Barnes et al, 2019).…”

Section: Resultsunclassified

Uso de fitoterápicos como alternativa para a diminuição da sintomatologia recorrente na gravidez

Rocha¹,

Santos²,

Resende³

et al. 2021

RSD

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Os extratos naturais de plantas vêm sendo utilizados com finalidades farmacológicas há milhares de anos. Seu uso na medicina popular foi propagado de cultura para cultura e descrito nas diversas literaturas. Para tanto, buscou-se analisar os benefícios da utilização de fitoterápicos frente aos sinais e sintomas recorrentes do período gravídico. Trata-se de uma revisão integrativa de literatura, de cunho descritivo com abordagem qualitativa. Para o alcance dos resultados, foram analisados os resumos de 284 artigos disponíveis na íntegra, assim como, patentes obtidas a partir do cruzamento entre os descritores. Destes, 26 estudos foram selecionados por responderem a pergunta norteadora: “O uso de fitoterápicos pode auxiliar no controle de sinais e sintomas advindos da gravidez?”, seguindo-se assim para a continuidade da pesquisa. Após leitura dos estudos, identificou-se que 29 espécies de plantas são utilizadas como fitoterápicos para o tratamento de sintomas recorrentes na gestação, destacando-se o gengibre, a camomila, a hortelã e o alho. Quanto à prospecção tecnológica, foram selecionadas seis patentes que, em sua discussão relataram o potencial farmacológico do gengibre, melancia, dentre outras, frente ao tratamento das sintomatologias comuns na gestação. Dessarte observa-se que apesar do crescimento progressivo da importância dos medicamentos fitoterápicos, poucos estudos foram realizados com o intuito de se comprovar a eficácia da sua utilização frente aos sintomas característicos do período gravídico, sendo que inúmeras plantas medicinais ainda são aplicadas a partir do conhecimento popular bem empregado, ressaltando assim a importância do tema abordado.

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Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms

Cited by 46 publications

References 136 publications

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence

Uso de fitoterápicos como alternativa para a diminuição da sintomatologia recorrente na gravidez

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