Plant-derived compounds in clinical trials

Saklani, Arvind; Kutty, Samuel K.

doi:10.1016/j.drudis.2007.10.010

Cited by 404 publications

(249 citation statements)

References 50 publications

Supporting

Mentioning

241

Contrasting

Unclassified

Order By: Relevance

“…One-hundred and eight plant-derived compounds, 24 animal (primarily marine) compounds, and 61 semisynthetic compounds out of 225 NPs were in development (Harvey 2008;Kingston 2011). A total of 26 plant-based drugs were approved/launched during 2000-2006(Saklani and Kutty 2008. Even though there are numerous examples of NPs that have reached the market, NP extracts (botanicals or phyto-pharmaceuticals) also play an essential role in therapy (examples will be discussed later in this review).…”

Section: Np Research At the Industry Levelmentioning

confidence: 99%

The pharmaceutical industry and natural products: historical status and new trends

2014

View full text Add to dashboard Cite

show abstract

Section: Np Research At the Industry Levelmentioning

confidence: 99%

The pharmaceutical industry and natural products: historical status and new trends

2014

View full text Add to dashboard Cite

show abstract

“…Landmarks of these clinical trials are flavopiridol, isolated from the Indian tree Dysoxylum binectariferum, and meisoindigo, isolated from the Chinese plant Indigofera tinctoria, which have been documented to have less toxicity than conventional chemotherapeutic anticancer drugs [17]. These discoveries have propelledthe scientific interest of various research groups in the discovery of new anticancer agents from all-natural product sources, inclusive of plant secondary metabolites.…”

Section: Role Of Herbal Medicine In the Treatment Of Cancermentioning

confidence: 99%

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

Gunjan

Naidu²,

Marzo³

et al. 2017

ijpm

View full text Add to dashboard Cite

A b s t r a c tThe already available expensive conventional therapies for cancer like chemotherapy and radiotherapy have a number of side effects such as myelosuppression and neurological, cardiac, pulmonary, and renal toxicity, which pose serious harm to the quality of there is a need to develop treatment options that include more potent and less toxic anticancer drugs as compared to existing drugs. and vegetables because of phytochemical compounds ex activity of antioxidant and free radicals which in turn showing anti semi agents are primarily used in com treatment of a variety of cancers. VLB is used for the treatment of leukaemia, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi's sarcoma, and VCR, in addition to the treat acute lymphocytic leukaemia in childhood. VRLB has shown activity against non lung cancer and advanced breast cancer. based, natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemot agents. drug development. The current findings and known anticancer agents from natural sources are discussed, and recent therapeutic advances in this field

show abstract

“…A range of plant/ crop species have been used in production of commercial pharma/crop products. An extensive review by Saklani and Kutty [145] describes the status on plant derived compounds in clinical trials with a special emphasis on plant-based anticancer drugs.…”

Section: Pharmaceutical Cropsmentioning

confidence: 99%

Genetic Engineering of Field, Industrial and Pharmaceutical Crops

Singh¹,

Singh²

2014

AJPS

View full text Add to dashboard Cite

Ability to modify plants at the genomic level by advanced molecular technology has enhanced the scope of improvements in plant traits attempted earlier through conventional breeding methods. Techniques such as genetic transformation have opened new vistas whereby functional genes, not commonly present in a particular species can be added from other species. The traits incorporated into the genetically engineered plants in the beginning were confined to those governed by dominant genes, e.g. insecticide resistance and herbicide tolerance but advancements with time now also permit the transfer of complexly inherited traits such as drought and cold tolerance. Transgenic technology is also useful in understanding gene expression and metabolic pathways which can then be used to harness the full genomic potential of the plant. This review presents a narrative on development of transgenics and their use for the improvement of field, industrial and pharmaceuticals crops. In addition, discussions are made on current status on genetically modified crops, hurdles to genetic engineering, overcoming strategies and future scope.

show abstract

Plant-derived compounds in clinical trials

Cited by 404 publications

References 50 publications

The pharmaceutical industry and natural products: historical status and new trends

The pharmaceutical industry and natural products: historical status and new trends

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

Genetic Engineering of Field, Industrial and Pharmaceutical Crops

Contact Info

Product

Resources

About