Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

Patil, Shital P.; Goswami, Ashutosh; Kalia, Kiran; Kate, Abhijeet S.

doi:10.1007/s10989-019-09899-z

Cited by 77 publications

(44 citation statements)

References 100 publications

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“…All 22 plants examined inhibited DPP-IV activity in vitro to some extent suggesting that such chemicals are commonly encountered in the plant kingdom. Studies to date suggest that these include alkaloids, glycosides, terpenoids, phenolic, flavonoids as well as protein hydrolysates and peptides [ 27 , 2 ]. These may act at the molecular level by binding to the active site of the enzyme, thereby inhibiting interactions with natural substrates.…”

Section: Discussionmentioning

confidence: 99%

“…Tamarindus indica ↓ ↑ ND [76] Terminalia arjuna ↓ ↑ ↑ [77,78] Azadirachta indica ↓ ↑ ↑ [79,80] Anogeissus latifolia ↓ ↑ ND [81] Albizia lebbeck ↓ ↑ ↑ [82,83] Chloropsis cochinchinensis ↓ ↑ ↑ [84] Cassia fistula ↓ ↑ ↑ [85,86] Dalbergia sisso ↓ ND ND [87,88] Swertia chirrayita ↓ ↑ ↑ [89] Withania coagulans ↓ ND ND [90,91] Licorice glyceriza ↓ ↓ ND [16,92,93] Momardica chirantia ↓ ↑ ND [94,95] Mangifera indica ↓ ↑ ↑ [96,97] Aegle marmelos ↓ ↑ ↑ [21] Trigonella foenum graecum ↓ ↑ ND [22,98] Effects of plant: -↑, increase; ↓, decrease (beneficial effect on hyperglycemia); ND, effect not determined 1 Effects on hyperglycemia were demonstrated in mice or rats given streptozotocin or alloxan or high fat diet to induce diabetes. 2 Effects on insulin secretion were demonstrated in vitro using pancreatic β-cells or in vivo using blood plasma of rats or mice. Beneficial actions in vitro were dose-dependent and did not affect cellular viability at low concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…T2DM patients are characterized by impaired β-cell function and insulin secretion together with tissue insulin resistance [ 1 ]. Since the prevalence and associated complications of T2DM are so damaging, more effective therapies are being sought to either delay or prevent the progression of T2DM [ 2 ]. As so, plants are most reliable source as studies to date found that they contain series of potential phytogroups including alkaloids, glycosides, terpenoids, phenolic, flavonoids and plant-derived peptides, each of them has shown potential antidiabetic activity in different experiment [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Since the prevalence and associated complications of T2DM are so damaging, more effective therapies are being sought to either delay or prevent the progression of T2DM [ 2 ]. As so, plants are most reliable source as studies to date found that they contain series of potential phytogroups including alkaloids, glycosides, terpenoids, phenolic, flavonoids and plant-derived peptides, each of them has shown potential antidiabetic activity in different experiment [ 2 ]. Besides, the diet of patients with T2DM plays a vital role in helping to maintain blood glucose control involving such factors as energy density, carbohydrate content, dietary fiber and natural products that may directly or indirectly affect the absorption of nutrients or the secretion and action of insulin [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

et al. 2021

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The present study investigated the effects of hot water extracts of 22 medicinal plants used traditionally to treat diabetes on Dipeptidyl peptidase-IV (DPP-IV) activity both in vitro and in vivo in high-fat fed (HFF) obese-diabetic rats. Fluorometric assay was employed to determine the DPP-IV activity. For in vivo studies, HFF obese-diabetic rats were fasted for 6 h and blood was sampled at different times before and after the oral administration of the glucose alone (18 mmol/kg body weight) or with either of the four most active plant extracts (250 mg/5 ml/kg, body weight) or established DPP-IV inhibitors (10 μmol/5 ml/kg). DPP-IV inhibitors: sitagliptin, vildagliptin and diprotin A, decreased enzyme activity by a maximum of 95–99% (P<0.001). Among the 22 natural anti-diabetic plants tested, AnogeissusLatifolia exhibited the most significant (P<0.001) inhibitory activity (96 ± 1%) with IC50 and IC25 values of 754 and 590 μg/ml. Maximum inhibitory effects of other extracts: Aegle marmelos, Mangifera indica, Chloropsis cochinchinensis, Trigonella foenum-graecum and Azadirachta indica were (44 ±7%; 38 ± 4%; 31±1%; 28±2%; 27±2%, respectively). A maximum of 45% inhibition was observed with >25 μM concentrations of selected phytochemicals (rutin). A.latifolia, A. marmelos, T. foenum-graecum and M. indica extracts improved glucose tolerance, insulin release, reduced DPP-IV activity and increased circulating active GLP-1 in HFF obese-diabetic rats (P<0.05–0.001). These results suggest that ingestion of selected natural anti-diabetic plants, in particular A. latifolia, A. marmelos, T. foenum-graecum and M. indica can substantially inhibit DPP-IV and improve glucose homeostasis, thereby providing a useful therapeutic approach for the treatment of T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

et al. 2021

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“…Plants are one of the major sources for nutrition and one of the easily available. The potential of plant‐derived bioactive peptides mainly resides in their pharmaceutical application (Patil et al., 2020). From the many plant‐based sources, cereals are widely used in daily diets.…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides with multiple activities extracted from Barley ( Hordeum vulgare L.) grain protein hydrolysates: Biochemical analysis and computational identification

Tok

Moulahoum

Kocazorbaz

et al. 2020

J Food Process Preserv

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Plant‐derived bioactive peptides demonstrate great potential given their availability and cost‐effectiveness. In this study, barley (Hordeum vulgare L.) grain proteins were explored for bioactive peptides with potential health applications. Gross grain proteins were obtained through aqueous extraction, after which, trypsin hydrolysis was performed. The hydrolysis process provided high peptide yields reaching 11%. The peptide hydrolysates were evaluated for their antioxidant and metal chelating activities, DPP4 inhibition, deglycation, and antimicrobial activity. The obtained results demonstrated biological activity levels of great importance and comparable to reference molecules. To confirm the experimental results, barley grain protein sequences were simulated for hydrolysis and explored for potential bioactive peptides using the FeptideDB. Indeed, barley grain proteins contain a great diversity of bioactive peptides with various biological activities. The current data highlights the promising therapeutic application of barley‐derived bioactive peptides. Further molecular and sequencing approaches are necessary to identify and characterize these peptides. Practical applications Barley (Hordeum vulgare L.) grain proteins are widely used cereals for nutrition and beverages. Their availability and low‐cost make them good sources for functional food exploration. We have described the potential of bioactive peptides obtained from barley grain proteins that have various activities including DPP4 inhibitory, antioxidant, antimicrobial, metal chelating, and deglycation activities. This data supports the potential of these peptides in biomedicine applications as a treatment option or as food supplement. Hence, the described peptide sequences could be exploited and industrialized by artificial synthesis and be proposed as food supplements or included in protein mixes for athletes.

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In Silico Identification of Potential Insect Peptides against Biofilm‐Producing Staphylococcus aureus

Sahoo

Swain

Panda

et al. 2022

Chemistry & Biodiversity

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Biofilm-producing Staphylococcus aureus (SA) strains are frequently found in medical environments, from surgical/ wound sites, medical devices. These biofilms reduce the efficacy of applied antibiotics during the treatment of several infections, such as cystic fibrosis, endocarditis, or urinary tract infections. Thus, the development of potential therapeutic agents to destroy the extra protective biofilm layers or to inhibit the biofilm-producing enzymes is urgently needed. Advanced and cost-effective bioinformatics tools are advantageous in locating and speeding up the selection of antibiofilm candidates. Based on the potential drug characteristics, we have selected one-hundred thirty-three antibacterial peptides derived from insects to assess for their antibiofilm potency via molecular docking against five putative biofilm formation and regulated target enzymes: the staphylococcal accessory regulator A or SarA (PDB ID: 2FRH), 4,4'-diapophytoene synthase or CrtM (PDB ID: 2ZCQ), clumping factor A or ClfA (PDB ID: 1N67) and serine-aspartate repeat protein C or SdrC (PDB ID: 6LXH) and sortase A or SrtA (PDB ID: 1T2W) of SA bacterium. In this study, molecular docking was performed using HPEPDOCK and HDOCK servers, and molecular interactions were examined using BIOVIA Discovery Studio Visualizer-2019. The docking score (kcal/mol) range of five promising antibiofilm peptides against five targets was recorded as follows: diptericin A (À 215.52 to À 303.31), defensin (À 201.11 to À 301.92), imcroporin (À 212.08 to À 287.64), mucroporin (À 228.72 to À 286.76), apidaecin II (À 203.90 to À 280.20). Among these five, imcroporin and mucroporin were 13 % each, while defensin contained only 1 % of positive net charged residues (Arg + Lys) projected through ProtParam and NetWheels tools. Similarly, imcroporin, mucroporin and apidaecin II were 50 %, while defensin carried 21.05 % of hydrophobic residues predicted by the tool PEPTIDE. 2.0. Most of the peptides exhibited potential characteristics to inhibit S. aureus-biofilm formation via disrupting the cell membrane and cytoplasmic integrity. In summary, the proposed hypothesis can be considered a cost-effective platform for selecting the most promising bioactive drug candidates within a limited timeframe with a greater chance of success in experimental and clinical studies.

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Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

Cited by 77 publications

References 100 publications

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

Bioactive peptides with multiple activities extracted from Barley ( Hordeum vulgare L.) grain protein hydrolysates: Biochemical analysis and computational identification

In Silico Identification of Potential Insect Peptides against Biofilm‐Producing Staphylococcus aureus

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