Plant derived anticancer agents: A green approach towards skin cancers

Ijaz, S.; Akhtar, Naveed; Khan, Muhammad Shoaib; Hameed, Abdul; Irfan, Muhammad; Arshad, Muhammad; Ali, Sajid; Asrar, Muhammad

doi:10.1016/j.biopha.2018.04.113

Cited by 117 publications

(98 citation statements)

References 97 publications

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“…Natural compounds have been investigated for their effects on numerous cancers, including gynaecological malignancies [79], glioblastoma [102], pancreatic cancer [103], breast cancer [104,105], lung cancer [106], prostate cancer [107], colorectal cancer [108,109] and melanoma/skin cancers [110][111][112]. Compounds are mainly selected for their anti-inflammatory properties although evidence has now been obtained that numerous compounds may induce direct killing of cancer cells, i.e., by apoptosis, but also because they can mediate cellular mechanisms and signalling pathways [113].…”

Section: Natural Compounds As Anti-cancer and Autoimmune Mediatorsmentioning

confidence: 99%

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Moody

Wilson

Jaworowski

et al. 2020

Cancers

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Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8+) T cells are correlated with a decreased risk of recurrence. As well as completely new antigen targets resulting from DNA mutations (neo-antigens), these T cells recognize cancer-associated overexpressed, re-expressed or modified self-proteins. However, there is concern that activation of self-reactive responses may also promote off-target pathology. This review considers the complex interplay between cancer-reactive and self-reactive immune cells and discusses the potential uses for various leading immunomodulatory compounds, derived from plant-based sources, as a cancer therapy option or to modulate potential autoimmune pathology. Along with reviewing well-studied compounds such as curcumin (from turmeric), epigallocatechin gallate (EGCG, from green tea) and resveratrol (from grapes and certain berries), it is proposed that compounds from novel sources, for example, native Australian plants, will provide a useful source for the fine modulation of cancer immunity in patients.

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Section: Natural Compounds As Anti-cancer and Autoimmune Mediatorsmentioning

confidence: 99%

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Moody

Wilson

Jaworowski

et al. 2020

Cancers

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“…Phytochemicals (plant secondary metabolites) are bioactive substances or active ingredients of plants which are responsible for its biological and medicinal properties [59]. They have found to be associated in the protection of humans against chronic degenerative diseases [60]. The term "Phytochemical" according to American Cancer Society refers to a wide variety of compounds produced by plants and can be found in fruits, vegetables, beans, grains etc.…”

Section: Active Secondary Metabolitesmentioning

confidence: 99%

Naturally Derived Formulations and Prospects towards Cancer

Masarkar¹,

Mukherjee²,

Goel³

et al. 2019

Health

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Traditional Medicine (TM) and their secondary metabolites are being increasingly recognized as useful complementary treatments toward the cancer. A large number of clinical studies have reported and proven concern of cancer patients. Here we have also reported recent studies on the biochemical and cellular mechanisms of Traditional Medicine (TM). Nowadays, Chemotherapy and surgery are standard methods for treatment of cancer, but still it's not been fully successful. Some progress has been made in cancer diagnosis and treatment, but high incidence rate of cancer and low survival rate of patient are still being reported worldwide. Since ancient times, a number of traditional medicines known as Ayurveda, Siddha, Unani, Iranian, Chinese, Korean, acupuncture, Muti, Ifa, and African medicine are widely used for therapeutic purposes and are becoming popular as Traditional Medicine (TM). It has been reported that plants synthesize plethora of "secondary metabolites" or "phytochemicals", proven to possess anti-mutagenic and anti-cancer properties in many research studies. There are many possibilities for further organized research for screening of medicinal plants for their potential and efficacy against chronic diseases such as a cancer and other inflammatory diseases. Therefore, researcher's interest should be in identification and standardization of new anti-cancer drug with low side effects and greater efficacy, that is easily acceptable in medical community and which may overcome the challenges in present and future cancer therapy. This review explores therapeutic value of certain bio-active principals of plant which could serve as potential pharmacologically active drug for treatment of cancer in future.

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“…C. sappan is commonly understood by Thai people as phang while U. rufa is known as pee paun noi. Various plants in the Leguminosae and Annonaceae families have been used by local Thai people as folk medicines for the treatment of urological disorders and prostatic diseases [12][13][14][15][16]. In addition, the heartwood of C. sappan is used to make phytotherapeutic agents to treat skin infections, inflammation, analgesic diarrhea, hypoglycemia, anemia and tuberculosis [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips

Buncharoen

Saenphet

2019

JPRI

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Aims: To determine the relaxant activity of various extracts from the stems of Uraria rufa Blume and Caesalpinia sappan L. on rats’ prostate strips in vitro. Study Design: The relaxant efficacies of ethyl acetate and ethanolic extracts from the stems of U. rufa (UEA and UEOH) and C. sappan (CEA and CEOH) were tested on isolated rats’ prostate tissue pre-contracted by adrenaline. Place and Duration of Study: Department of Biology, Faculty of Science, Chiang Mai University, between February and September 2018. Methodology: A prostate strip was isolated, mounted in an organ bath filled with Krebs-Henseleit solution and induced to contract by adrenaline. The contracted strip was then exposed to each extract at 250 µg/mL for 30 minutes. The tension was recorded. Relaxant efficacies of various extracts were determined in prostate strips pre-contracted by adrenaline at 10 µM. All extracts were also determined for their bioactive components and the contents of total phenolics and total flavonoids. Results: The results showed that all of the extracts, as well as tamsulosin, a synthetic drug, exhibited relaxant effects (P < 0.001) on prostate smooth muscles. The UEA exhibited the most potency in relaxing the prostate smooth muscle with a maximal effect of 72.09 ± 2.15 %. The half-maximal effective concentration (EC50) values of the UEA, CEOH, UEOH and CEA were 140.23 ± 9.74, 226.35 ± 7.16, 235.35 ± 24.96 and 236.24 ± 5.05 µg/ml respectively, while tamsulosin was 86.83 ± 8.96 µg/ml. All extracts contained flavonoids, phenolics, sterols, tannins, phlobatannins, terpenoids, cardiac glycosides, alkaloids and reducing sugars. The highest contents of phenolics and flavonoids were found in CEOH and CEA respectively. Conclusion: We concluded that the ethyl acetate from the stems of U. rufa was the most potent in relaxing the prostate smooth muscles, and it may be useful to relieve the urological symptoms caused by benign prostatic hyperplasia (BPH).

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Plant derived anticancer agents: A green approach towards skin cancers

Cited by 117 publications

References 97 publications

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Naturally Derived Formulations and Prospects towards Cancer

Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips

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