Plant composition, pharmacological properties and mutagenic evaluation of a commercial Zulu herbal mixture: Imbiza ephuzwato

Ndhlala, A.R.; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.jep.2010.10.053

Cited by 57 publications

(61 citation statements)

References 25 publications

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“…Except for the aqueous extracts of Tetradenia riparia and Coddia rudis that showed good inhibitory activities against COX-1 and COX-2 enzymes respectively, all the other aqueous extracts in this investigation demonstrated poor inhibitory activity against both COX enzymes. Contrary to a previous study (Ndhlala et al, 2011) aqueous extracts of Tetradenia riparia exhibited COX-1 inhibitory activity to a greater extent than the COX-2 enzyme. These differences in activities might be due to the effect of harvesting time or storage of plant materials.…”

Section: Anti-inflammatory Activity Of Plant Extractscontrasting

confidence: 99%

Pharmacological, genotoxic and phytochemical properties of selected South African medicinal plants used in treating stomach-related ailments

Okem

Finnie

Staden

2012

Journal of Ethnopharmacology

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Section: Anti-inflammatory Activity Of Plant Extractscontrasting

confidence: 99%

Pharmacological, genotoxic and phytochemical properties of selected South African medicinal plants used in treating stomach-related ailments

Okem

Finnie

Staden

2012

Journal of Ethnopharmacology

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“…Previous studies have shown the anti-inflammatory effects of T. riparia extract on prostaglandins, cyclooxygenase 1 (COX 1), and cyclooxygenase 2 (COX 2), but its effect on iNOS has been unknown (Ndhlala, et al, 2011, Okem, et al, 2012. In leishmaniasis, this increase in iNOS may influence the nitric oxide production and promote elimination of the parasite.…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia

Demarchi

Thomazella

Terron

et al. 2015

Experimental Parasitology

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Tetradenia riparia plant is used as a traditional medicine in Africa for the treatment of inflammatory and infectious diseases as like parasitic. Therapy for leishmaniasis caused by Leishmania (Leishmania) amazonensis specie often fails, and the conventional drugs are toxic, expensive, require a long period of treatment, and adverse effects are common. The alternative therapies using natural products are inexpensive and have few or any adverse reaction. These reasons are sufficient to investigate the new natural therapeutic for leishmaniasis. We evaluated the potential of the essential oil (TrEO) and 6,7-dehydroroyleanone (TrROY) isolated from T. riparia on L. (L.) amazonensis promastigote and amastigote forms, cytotoxicity on human erythrocytes and murine macrophages, nitric production and inducible nitric oxide synthase (iNOS) mRNA expression. TrEO was the most effective to promote the Leishmania promastigote death. After 72 h incubation, the lethal dose of TrEO and TrROY that promoted 50% Leishmania death (LD50) were 0.8 μg/mL and 3 μg/mL, respectively. TrEO and TrROY were not cytotoxic to human erythrocytes, but TrROY was toxic to murine macrophages resulting in a low selectivity index. The transmission electronic microscopy showed that TrEO (0.03 μg/mL) was able to modify the promastigote ultrastructures suggesting autophagy as chromatin condensation, blebbing, membranous profiles and nuclear fragmentation. Infected-macrophages treated with TrEO (0.03 μg/mL) or TrROY (10 μg/mL) had an infection index decreased in 65 and 48%. TrEO did not induce iNOS mRNA expression or nitrite production in macrophages infected with Leishmania. TrROY and mainly TrEO promoted the Leishmania death, and TrROY showed loss toxicity to erythrocytes cells. Other compounds derived from T. riparia and the essential oil could be explored to develop a new alternative treatment for leishmaniasis.

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“…Peron et al, (2013) showed that this plant had no mutagenic potential in subchronic gavage treatments (0.3, 3.0 and 30.0 mg/mL). Ndhlala et al, (2011) determined that H. aethiopicum was not mutagenic by the Ames test with Salmonella Typhimurium. The reports support the results obtained from this work.…”

Section: Discussionmentioning

confidence: 99%

The Biological Activities of Hypericum Perforatuml

Ökmen¹,

Balpinar²

2016

AJTCAM

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Background: Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed in bacteria. Today's researches are focused on discovering and using new antibiotics against bacteria. Objective: The aim of this work was to discover the antibacterial effects of Hypericum perforatum L. extracts against mastitis pathogens, and its other biological activities. Material and Methods: Kirby-Bauer assay was applied to the extracts. The other antibacterial activity was MIC for plant extracts. The non-enzymatic antioxidant activity was found using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH). Results: The extract was showed maximum inhibition zone against two bacteria (Coagulase-negative Staphylococci-33 and 37; CNS 33 and 37), and the zone was 17 mm. A bacterium (CNS -22) showed the lowest sensitivity to 812.5 µg /mL concentration. In addition, the extract was tried against the stable DPPH for antioxidant activity. As a result, the extract showed a strength antioxidant activity. Trolox equivalent is 0.83 mM. Conclusion:The extract of Hypericum perforatum have antibacterial, antioxidant and antimutagenic potentials.

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Plant composition, pharmacological properties and mutagenic evaluation of a commercial Zulu herbal mixture: Imbiza ephuzwato

Cited by 57 publications

References 25 publications

Pharmacological, genotoxic and phytochemical properties of selected South African medicinal plants used in treating stomach-related ailments

Pharmacological, genotoxic and phytochemical properties of selected South African medicinal plants used in treating stomach-related ailments

Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia

The Biological Activities of Hypericum Perforatuml

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