In recent times, nanomedicine has effectively addressed the poor delivery, solubility, absorption or cytotoxicity issues of conventional and herbal drugs. Several herbals or bioactive metabolites because of their ability to efficiently reduce and stabilize metal ions have been exploited as herb-synthesized gold and silver nanoparticles. Outbreaks of pathogenic viruses cause significant morbidity and mortality, worldwide. Of these, the novel SARS-Coronavirus-2 disease (COVID-19) remains the most devastating pandemic ever. In view of this, herbal gold and silver nanoparticles have been developed as antiviral drug-delivery carriers against Human immunodeficiency virus, Herpes virus, Influenza virus, Dengue virus, Chikungunya virus and Hepatitis B virus etc. Notable examples include Astragalus membranaceus, Tinospora cordifolia, Phyllanthus niruri, Andrographis paniculate, Lampranthus coccineus and Malephora lutea synthesized antiviral nanoparticles. Although further studies have shown that such herbal-synthesized nanoparticles could enter the target cells and inhibit virus replication, their interactions with different cell types and the specific mechanism of antiviral activities still remain inconclusive.