Plant-based mucilage with healing and anti-inflammatory actions for topical application: A review

Filho, Josemar Gonçalves de Oliveira; Lira, Michelle Monteiro; Sousa, Tainara Leal de; Campos, Stéphani Borges; Lemes, Ailton César; Egea, Mariana Buranelo

doi:10.1016/j.fhfh.2021.100012

Cited by 23 publications

(11 citation statements)

References 135 publications

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“…It is important to note that, even without the drug, F 1 C 1 promoted wound healing; however, this effect was considerably less when compared to the drug-loaded film group. This effect could be related to FSG, as one study delineated the wound-healing properties of flaxseed mucilage [ 58 ]. The wounds were not healed completely in the DFX solution group (D and I), with the evident proliferation of the fibroblasts, weaker angiogenesis, and poor reepithelization.…”

Section: Resultsmentioning

confidence: 99%

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Sadiq

Khalid

Khan

et al. 2022

Gels

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In this study, biocomposite hydrogel films made from flaxseed gum (FSG)/kappa carrageenan (CGN) were fabricated, using potassium chloride as a crosslinker and glycerol as a plasticizer. The composite films were loaded with deferoxamine (DFX), an iron chelator that promotes neovascularization and angiogenesis for the healing of wounds. The properties of the biocomposite hydrogel films, including swelling, solubility, water vapor transmission rate, tensile strength, elongation at break, and Young’s modulus studies, were tested. The films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). In addition, drug release studies in PBS at pH 7.2 were investigated. In vivo analysis was performed by assessing the wound contraction in a full-thickness excisional wound rat model. Hematoxylin & eosin (H & E) and Masson’s trichome staining were performed to evaluate the effect of the films on wound healing progress. The visual and micro-morphological analysis revealed the homogenous structure of the films; however, the elongation at break property decreased within the crosslinked film but increased for the drug-loaded film. The FTIR analysis confirmed the crosslinking due to potassium chloride. A superior resistance towards thermal degradation was confirmed by TGA for the crosslinked and drug-loaded films. Drug release from the optimum film was sustained for up to 24 h. In vivo testing demonstrated 100% wound contraction for the drug-loaded film group compared to 72% for the pure drug solution group. In light of the obtained results, the higher potential of the optimized biocomposite hydrogel film for wound healing applications was corroborated.

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Section: Resultsmentioning

confidence: 99%

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Sadiq

Khalid

Khan

et al. 2022

Gels

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“…Initially, by stimulating inflammation, TGF‐β3 cultivates an environment that is favourable for the process of healing. Nevertheless, as the process of healing advances, it transitions to anti‐inflammatory function, aiding in the reduction of excessive inflammatory reactions and facilitating tissue regeneration 23 …”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, as the process of healing advances, it transitions to anti-inflammatory function, aiding in the reduction of excessive inflammatory reactions and facilitating tissue regeneration. 23 TGF-β3 contributed to the wound healing process in numerous ways, operating as both an anti-inflammatory and pro-inflammatory mediator. The stages of wound healing are intricately intertwined with its expression, as it exerts an impact on inflammation, proliferation and remodelling.…”

Section: Dual Role Of Tgf-β3mentioning

confidence: 99%

Role of TGF‐β3 in modulating inflammatory responses and wound healing processes in ischemic ulcers in atherosclerotic patients

Ma,

Tang,

Wang

et al. 2024

International Wound Journal

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Ischemic ulcers pose a multifaceted clinical dilemma for patients with atherosclerosis, frequently compounded by suboptimal wound healing mechanisms. The dual function of Transforming Growth Factor Beta 3 (TGF‐β3) in ischemic ulcer healing is not fully comprehended, despite its involvement in modulating inflammatory responses and tissue regeneration. The main aim of this investigation was to clarify the functions and mechanisms by which TGF‐β3 regulates inflammatory responses and promotes wound healing in patients with ischemic ulcers who have atherosclerosis. Between August 2022 and November 2023, this cross‐sectional investigation was conducted on 428 patients diagnosed with atherosclerotic ischemic ulcers in Haikou, China. The expression and function of TGF‐β3 were examined throughout the different stages of wound healing, including inflammation, proliferation and remodelling. In addition to documenting patient demographics and ulcer characteristics, an analysis was conducted on biopsy samples to determine the expression of TGF‐β3, pro‐inflammatory and anti‐inflammatory markers. A subset of patients were administered topical TGF‐β3 in order to evaluate its therapeutic effects. The expression pattern of TGF‐β3 was found to be stage‐dependent and significant, exhibiting increased levels during the phase of inflammation and reduced activity in subsequent phases. TGF‐β3 levels were found to be greater in ulcers that were larger and deeper, especially in inflammatory phase. TGF‐β3 applied topically induced discernible enhancement in ulcer healing parameters, such as reduction in ulcer depth and size. The therapeutic significance of TGF‐β3 was emphasised due to its twofold function of regulating the inflammatory environment and facilitating the regeneration of damaged tissues. Ischemic ulcer lesion healing is significantly influenced by TGF‐β3, which functions as an anti‐inflammatory and pro‐inflammatory mediator. Its correlation with ulcer characteristics and stages of healing suggests that it may have utility as a targeted therapeutic agent.

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“…Sunflower meal extract, rich in antioxidants, does not present a limited use, as it can be useful in the pharmaceutical and food industries, making it applicable in phytomedicine or when formulated as a food additive to prevent rancidity caused by lipid oxidation 44,74,85 . Furthermore sunflower meal could be valued as a source of precursors in matrices for the development of active and bioactive food packaging 44,86 . Therefore, the use of an aqueous extract obtained by an adsorption–desorption process with activated carbon may also contribute to overcoming the underutilization of sunflower meal and consequently reducing the environmental impact generated by oil production.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic analysis and ecofriendly enrichment of sunflower meal extract

et al. 2022

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BACKGROUND The presence of phenolic compounds in sunflower is well reported in the literature; however, knowledge is scarce when it comes to the composition of other secondary metabolites in this species and their by‐products. This work evaluated, for the first time, the phytochemical composition of sunflower meal produced in Brazil. A combination of mixture design and central composite rotatable design 23 models was then applied to maximize the recovery of bioactive compounds using ecologically friendly solvents and concentrating by applying activated carbon, a sustainable adsorbent. The product of this extraction–concentration was also evaluated by an untargeted metabolomic approach using ultra‐performance liquid chromatography coupled to mass spectrometry. RESULTS A diverse and abundant profile of phenolic compounds was obtained from Brazilian sunflower meal: in total, 51 natural products were tentatively identified, 35 of which for the first time in sunflower. The sorption capacity of the activated charcoal, in the optimized process conditions, was effective in the separation and concentration of minority secondary metabolites. The ecofriendly extract proved to be enriched in plumberoside, p‐coumaric acid, and alkaloids. CONCLUSIONS Investigation of the phytochemical profile of sunflower meal produced in Brazil pointed to several secondary metabolites reported for the first time in sunflower samples, including phenolic compounds, alkaloids, and terpenes. The use of activated charcoal in an alkaline medium as an adsorbent for the concentration of these phytochemicals, from an aqueous extract, generated a potentially cost‐effective, ecofriendly extract, enriched in minor metabolites, indicating a possible innovative way to selectively obtain these compounds from sunflower meal. © 2022 Society of Chemical Industry.

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Plant-based mucilage with healing and anti-inflammatory actions for topical application: A review

Cited by 23 publications

References 135 publications

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Role of TGF‐β3 in modulating inflammatory responses and wound healing processes in ischemic ulcers in atherosclerotic patients

Metabolomic analysis and ecofriendly enrichment of sunflower meal extract

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