Plant Anticancer Agents V: New Bisindole Alkaloids from Tabernaemontana johnstonii Stem Bark

Kingston, David G. I.; Gerhart, Bruce B.; Ionescu, Florin; Mangino, Mario M.; Sami, Salah M.

doi:10.1002/jps.2600670232

Cited by 32 publications

(14 citation statements)

References 14 publications

(11 reference statements)

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“…Many alkaloids are known to be genotoxic [39–43]. However, many of these alkaloids have also demonstrated an outstanding pharmacological potential, exhibiting antimicrobial, antiplasmodial and antitumoral activities [44, 45]. …”

Section: Discussionmentioning

confidence: 99%

Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Calvo

Cardoso

Moura

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.

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Section: Discussionmentioning

confidence: 99%

Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Calvo

Cardoso

Moura

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…A study on the content of twigs of K. arborea grown in Thailand revealed the isolation of a new MIA, phutdonginin (191) [100], an eburnane-type compound, together with eight known compounds, among them, 164 [87], 189 [88] melodinine E (192) [101], kopsilongine (193), kopsamine (194) [94], (−)-methylenedioxy-11,12-kopsinaline (195) [87], decarbomethoxykopsiline (196) [102], and vincadifformine (197) [103]. Only 194 and 196 displayed AChE inhibition activity with MIR values 12.5 and 6.25 µg, respectively, compared with reference drug galanthamine MIR = 0.004 µg.…”

Section: Kopsiamentioning

confidence: 99%

“…Conodusine A-E (370-374), apocidine A (375) and B (376), conoduzidine A (377), tabernamidine A (378) and B (379) (Figure 29) were isolated from the Malaysian stem-bark of Tabernaemontana corymbose malaysian [193]. Additionally, thirty-two compounds were also identified from the same plant, including 307, 314, 338, (+)-catharanthine (380), tabernamine (381) [194], 19 (S)-hydroxytabernamine (382) [195], and 19 (R)-hydroxytabernamine (383) [195]. 16 -decarbomethoxyvoacamine (384) [180] (Figure 29).…”

Section: Tabernaemontanamentioning

confidence: 99%

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera

et al. 2021

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By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery. However, in the recent times, natural compounds regained their position as extremely important source drug leads. Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc. Monoterpene Indole Alkaloids (MIAs) deserve the curiosity and attention of researchers due to their chemical diversity and biological activities. These compounds were considered as an impending source of drug-lead. In this review 444 compounds, were identified from six genera belonging to the family Apocynaceae, will be discussed. These genera (Alstonia, Rauvolfia, Kopsia, Ervatamia, and Tabernaemontana, and Rhazya) consist of 400 members and represent 20% of Apocynaceae species. Only 30 (7.5%) species were investigated, whereas the rest are promising to be investigated. Eleven bioactivities, including antibacterial, antifungal, anti-inflammatory and immunosuppressant activities, were reported. Whereas cytotoxic effect represents 47% of the reported activities. Convincingly, the genera selected in this review are a wealthy source for future anticancer drug lead.

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“…This chemical family is one of the most important biologically active secondary metabolites found in the plant kingdom with multilateral biological activities [ 30 , 31 ]. Gabunamine, gabunine, and tabernamine from Tabernaemontana johnstonii BE exhibited important cytotoxicity against the P-388 mouse lymphocytic leukemia cell culture system [ 32 ]. Paclitaxel obtained from BE a few decades ago is part of this family of active anticancer bio compounds and was used in the treatment of ovarian cancer.…”

Section: Anticancer Potential Of Bioactive Compounds From Bark Extracts (Be) In Different Type Of Suppressed Cancer Cells Linesmentioning

confidence: 99%

Anticancer Potential of Natural Bark Products—A Review

Burlacu

Tănase

2021

Plants

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Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved chemotherapeutics. Forestry residues can be used for their wealthy resource in polyphenols and other phytoconstituents known for anticancer properties. This review is designed to bring together information on the in vitro or in vivo anticancer potential of woody vascular plants especially the bark extracts (BE) and biosynthesized metallic nanoparticles (BMN) using bark extracts. Type of extracts, main phytoconstituents found in extracts responsible for the anticancer activity, and targeted cancerous cell lines were followed. The literature data were collected via Clarivate Analytics, Science Direct, PubMed, and Google Academic (2011–2021). The search terms were: bark extracts, metallic nanoparticles, silver nanoparticles, gold nanoparticles, anticancer, cytotoxic activity, antiproliferative effect, and antimetastatic potential in vitro and in vivo. All of the search terms listed above were used in different combinations. The literature data highlight the efficaciousness of the BE and BMN as anticancer agents in in vitro experiments and showed the mechanism of action and their advantage of nontoxicity on normal cells. In vitro testing has shown promising results of the BE and BMN effect on different cancer cell lines. In vivo testing is lacking and more data is necessary for drug development on animal models.

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Plant Anticancer Agents V: New Bisindole Alkaloids from Tabernaemontana johnstonii Stem Bark

Cited by 32 publications

References 14 publications

Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera

Anticancer Potential of Natural Bark Products—A Review

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