Plant Acyl-CoA-Binding Proteins—Their Lipid and Protein Interactors in Abiotic and Biotic Stresses

Lai, Sze-Han; Chye, Mee‐Len

doi:10.3390/cells10051064

Cited by 14 publications

(14 citation statements)

References 184 publications

(421 reference statements)

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“…Acyl-CoA-binding proteins (ACBPs), a family of conserved proteins among prokaryotes and eukaryotes, bind to various acyl-CoA esters with different affinities and play a role in the transport and maintenance of subcellular acyl-CoA pools, indicating their importance in biological function ( Lai and Chye, 2021 ). The involvement of ACBPs in vital processes such as lipid metabolism, regulation of enzyme and gene expression, and response to plant stresses has been proven in several studies ( Raboanatahiry et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…ACBPs were divided into four subgroups according to molecular mass and domain architecture ( Meng et al, 2011 ). ACBPs have been identified in about 13 plant species ( Lung and Chye, 2016b ; Lung and Chye, 2016b ; Du et al, 2016 ; Lai and Chye, 2021 ). However, except for Soybean ( Glycine max ; Azlan et al, 2021 ; Lung et al, 2021 ), the characterization of other legumes ACBPs had remained unreported, even though these legumes are a globally crucial commercial crop cultivated for vegetables, oil crops, high protein crops, and plays a significant role in the food and chemical industries.…”

Section: Discussionmentioning

confidence: 99%

“…In nine legumes, some predicted interacting proteins were similar to previous reports such as heavy metal-associated protein and ethylene-responsive transcription factor, they are also predicted to interact with polyubiquitin, ubiquitin-protein, phosphatidylinositol kinase, ubiquitin domain-containing protein, cyclin-dependent kinase inhibitor, and calcium-dependent protein kinase. ACBP protein-protein interactions are important in regulating plant development and abiotic and biotic stress responses ( Lung and Chye, 2016b ; Du et al, 2016 ; Lung and Chye, 2019 ; Lai and Chye, 2021 ). As a result, validating the predicted ACBPs interacting proteins and further exploring their possible biological functions are warranted.…”

Section: Discussionmentioning

confidence: 99%

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Genome-wide identification of acyl-CoA binding proteins and possible functional prediction in legumes

Ling

Li²,

Lin³

et al. 2023

Front. Genet.

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Acyl-CoA-binding proteins (ACBPs), members of a vital housekeeping protein family, are present in various animal and plant species. They are divided into four classes: small ACBPs (class I), ankyrin-repeat ACBPs (class II), large ACBPs (class III), and kelch-ACBPs (class IV). Plant ACBPs play a pivotal role in intracellular transport, protection, and pool formation of acyl-CoA esters, promoting plant development and stress response. Even though legume crops are important for vegetable oils, proteins, vegetables and green manure, legume ACBPs are not well investigated. To comprehensively explore the functions of ACBPs in nine legumes (Lotus japonicus, Medicago truncatula, Glycine max, Vigna angularis, Vigna radiata, Phaseolus vulgaris, Arachis hypogaea, Arachis duranensis, and Arachis ipaensis), we conducted genome-wide identification of the ACBP gene family. Our evolutionary analyses included phylogenetics, gene structure, the conserved motif, chromosomal distribution and homology, subcellular localization, cis-elements, and interacting proteins. The results revealed that ACBP Orthologs of nine legumes had a high identity in gene structure and conserved motif. However, subcellular localization, cis-acting elements, and interaction protein analyses revealed potentially different functions from previously reported. The predicted results were also partially verified in Arachis hypogaea. We believe that our findings will help researchers understand the roles of ACBPs in legumes and encourage them to conduct additional research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genome-wide identification of acyl-CoA binding proteins and possible functional prediction in legumes

Ling

Li²,

Lin³

et al. 2023

Front. Genet.

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“…One hypothesis is that the interaction of ACBPs with heavy metal binding proteins could have a regulatory function by affecting the Cu 2+ -mediated ethylene binding and signaling through AtEBP [ 13 , 61 , 62 ]. Finally, some members of the ACBP family are involved in the abiotic stress responses and leaf senescence [ 63 ], through the regulation of specific phytohormones. Specifically, AtACBP2 was induced by ABA and conferred resistance to drought stress and enhanced the ABA-mediated leaf senescence [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

The Barley Heavy Metal Associated Isoprenylated Plant Protein HvFP1 Is Involved in a Crosstalk between the Leaf Development and Abscisic Acid-Related Drought Stress Responses

Parasyri

Barth²,

Zschiesche³

et al. 2022

Plants

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The heavy metal associated isoprenylated plant proteins (HIPPs) are characterized by at least one heavy metal associated (HMA) domain and a C-terminal isoprenylation motif. Hordeum vulgare farnesylated protein 1 (HvFP1), a barley HIPP, is upregulated during drought stress, in response to abscisic acid (ABA) and during leaf senescence. To investigate the role of HvFP1, two independent gain-of-function lines were generated. In a physiological level, the overexpression of HvFP1 results in the delay of normal leaf senescence, but not in the delay of rapid, drought-induced leaf senescence. In addition, the overexpression of HvFP1 suppresses the induction of the ABA-related genes during drought and senescence, e.g., HvNCED, HvS40, HvDhn1. Even though HvFP1 is induced during drought, senescence and the ABA treatment, its overexpression suppresses the ABA regulated genes. This indicates that HvFP1 is acting in a negative feedback loop connected to the ABA signaling. The genome-wide transcriptomic analysis via RNA sequencing revealed that the gain-of-function of HvFP1 positively alters the expression of the genes related to leaf development, photomorphogenesis, photosynthesis and chlorophyll biosynthesis. Interestingly, many of those genes encode proteins with zinc binding domains, implying that HvFP1 may act as zinc supplier via its HMA domain. The results show that HvFP1 is involved in a crosstalk between stress responses and growth control pathways.

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“…The strongest complexes are formed with acyl-CoA esters with a chain length of C18 and C20. In contrast to animal and yeast proteins, plant ACBPs, in addition to acyl-CoA esters, appear to be able to associate with at least one class of phospholipids such as lysoPC, DIPC, phosphatidic acid (PA), and phosphatidylethanolamine (PE) with saturated and unsaturated acyl tails with a chain length from C16 to C18 [ 71 , 83 , 84 ]. In addition to phospholipid binding, arabidopsis ACBPs (AtACBPs) were shown to interact with proteins.…”

Section: Features Of Plant Lipid-binding and Transfer Proteinsmentioning

confidence: 99%

Features and Possible Applications of Plant Lipid-Binding and Transfer Proteins

et al. 2022

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In plants, lipid trafficking within and inside the cell is carried out by lipid-binding and transfer proteins. Ligands for these proteins are building and signaling lipid molecules, secondary metabolites with different biological activities due to which they perform diverse functions in plants. Many different classes of such lipid-binding and transfer proteins have been found, but the most common and represented in plants are lipid transfer proteins (LTPs), pathogenesis-related class 10 (PR-10) proteins, acyl-CoA-binding proteins (ACBPs), and puroindolines (PINs). A low degree of amino acid sequence homology but similar spatial structures containing an internal hydrophobic cavity are common features of these classes of proteins. In this review, we summarize the latest known data on the features of these protein classes with particular focus on their ability to bind and transfer lipid ligands. We analyzed the structural features of these proteins, the diversity of their possible ligands, the key amino acids participating in ligand binding, the currently known mechanisms of ligand binding and transferring, as well as prospects for possible application.

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Plant Acyl-CoA-Binding Proteins—Their Lipid and Protein Interactors in Abiotic and Biotic Stresses

Cited by 14 publications

References 184 publications

Genome-wide identification of acyl-CoA binding proteins and possible functional prediction in legumes

Genome-wide identification of acyl-CoA binding proteins and possible functional prediction in legumes

The Barley Heavy Metal Associated Isoprenylated Plant Protein HvFP1 Is Involved in a Crosstalk between the Leaf Development and Abscisic Acid-Related Drought Stress Responses

Features and Possible Applications of Plant Lipid-Binding and Transfer Proteins

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