“…Previous studies have employed these techniques, including both 2D analyses based on surface maps and 3D analyses [8] , [9] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] . To the best of our knowledge, there have been limited studies focusing on adapting treatment plans to spare SRSs volumes [26] , [27] . To address this issue, advanced techniques such as Multi-Criteria Optimization (MCO) could be employed for the fine tuning of the dose distributions.…”