“…Negative histological margins were obtained after the first stage in 86% (89/103) using HH‐RCM prior to SE, 58,67 compared with 50% (217/433) without HH‐RCM 47,53,57,61,66,68 ( p < 0.0001). For MMS‐treated patients ( n = 894) the weighted mean ± SD (range) stages for histological clearance was 1.6 ± 0.3 (1.4–2.3), 34,35,37,40,43,69–71 compared to 1.3 with HH‐RCM mapping prior to MMS ( n = 21) 35 ( p < 0.001). Negative histological margins were obtained after the first stage in 81% (17/21) using HH‐RCM prior to MMS, 35 compared with 77% (1333/1723) without HH‐RCM 35,36,43,59,70,72 ( p = 0.69).…”