Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium

Ohata, Shinya; Alvarez-Buylla, Arturo

doi:10.1016/j.tins.2016.05.004

Cited by 67 publications

(96 citation statements)

References 91 publications

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“…The connection between centriole polarization/localization and PCP-signaling has been studied in several systems, and in all systems where centrioles/BBs and PCP have been analyzed together, polarization of PCP complexes precedes and is independent of centrioles/BBs positioning. The models tested now also include Drosophila wing epithelia (a simpler model as no cilia form here), and this model is consistent with observations in vertebrate node, neural tube, tracheal epithelia, ependymal cells, and inner ear sensory hair cells and supportive cells [22, 31–33, 53, 132]. All data from these models are consistent with core Fz-PCP signaling acting upstream of centriole or ciliary polarization and positioning.…”

Section: Discussionsupporting

confidence: 79%

“…1C) [32]. This coordinated display along the tissue contributes to the physiological function of these cells in their respective contexts, like for example removing the dust and mucus from the apical membrane in the trachea, or helping the cerebro-spinal fluid (CSF) flow inside the brain ventricles, or proper hearing in the inner ear cells [31–33]. …”

Section: Do Centrioles Move In Epithelial Cells?mentioning

confidence: 99%

“…Many of them associated with defects in cilia associated signaling and function (e.g. Meckel–Gruber syndrome) or neural tube closure defects like spina bifida or hydrocephalus, and ciliopathies in general [33,58,59,63–66]. On the other side of the evolutionary spectrum, in planaria, PCP signaling controls neuronal connectivity and animal body shape [45].…”

Section: The Pcp Pathway Has Different Outcomesmentioning

confidence: 99%

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Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity

2016

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Planar cell polarity (PCP)-signaling and associated tissue polarization are evolutionarily conserved. A well documented feature of PCP-signaling in vertebrates is its link to centriole/cilia positioning, although the relationship of PCP and ciliogenesis is still debated. A recent report in Drosophila established that Frizzled (Fz)-PCP core signaling has an instructive input to polarized centriole positioning in non-ciliated Drosophila wing epithelia as a PCP read-out. Here, we review the impact of this observation in the context of recent descriptions of the relationship(s) of core Fz-PCP signaling and cilia/centriole positioning in epithelial and non-epithelial cells. All existing data are consistent with a model where Fz-PCP signaling functions upstream of centriole/cilia positioning, independent of ciliogenesis. The combined data sets indicate that the Fz-Dsh PCP complex is instructive for centriole/ciliary positioning via an actin-based mechanism. Thereby, centriole/cilia/centrosome positioning can be considered an evolutionarily conserved readout and common downstream effect of PCP-signaling from flies to mammals.

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Section: Discussionsupporting

confidence: 79%

Section: Do Centrioles Move In Epithelial Cells?mentioning

confidence: 99%

Section: The Pcp Pathway Has Different Outcomesmentioning

confidence: 99%

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Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity

2016

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“…In addition to ECM-based mechanosignals, fluid flow also contributes to neural cell organization and differentiation. The proper orientation of ependymal cells requires forces generated by cerebral spinal fluid (CSF) flow, and coordinated beating of their cilia drives further CSF flow in the developing brain (Ohata and Alvarez-Buylla, 2016;Guirao et al, 2010). The resulting shear forces along the ventricles direct neuroblast alignment and migration (Sawamoto et al, 2006), and consistently, physical obstruction of CSF during development leads to decreased neurogenesis and severe developmental defects (Mashayekhi et al, 2002).…”

Section: Mechanical Forces Guide Brain Developmentmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

252

245

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All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surprisingly, disease develops if these mechanical cues are abnormal or are misinterpreted by the cells – for example, when interstitial pressure or compression force aberrantly increases, or the extracellular matrix (ECM) abnormally stiffens. Disease might also develop if the ability of cells to regulate their contractility becomes corrupted. Consistently, disease states, such as cardiovascular disease, fibrosis and cancer, are characterized by dramatic changes in cell and tissue mechanics, and dysregulation of forces at the cell and tissue level can activate mechanosignaling to compromise tissue integrity and function, and promote disease progression. In this Commentary, we discuss the impact of cell and tissue mechanics on tissue homeostasis and disease, focusing on their role in brain development, homeostasis and neural degeneration, as well as in brain cancer.

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“…Recent data suggest that CHC may result from genetic or epigenetic abnormalities in cell junction biology [29,30] , ependymal cell polarity, defects in primary or motile cilia [31][32][33][34] , subventricular precursor cell biology (e.g. migration) [35] , or other developmental pathology [1,36] .…”

Section: Csf Biomarkers Of Congenital Hydrocephalusmentioning

confidence: 99%

Cerebrospinal Fluid Biomarkers of Pediatric Hydrocephalus

Limbrick¹,

Castañeyra-Ruiz²,

Han³

et al. 2017

Pediatr Neurosurg

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Hydrocephalus (HC) is a common, debilitating neurological condition that requires urgent clinical decision-making. At present, neurosurgeons rely heavily on a patient's history, physical examination findings, neuroimaging, and clinical judgment to make the diagnosis of HC or treatment failure (e.g., shunt malfunction). Unfortunately, these tools, even in combination, do not eliminate subjectivity in clinical decisions. In order to improve the management of infants and children with HC, there is an urgent need for new biomarkers to complement currently available tools and enable clinicians to confidently establish the diagnosis of HC, assess therapeutic efficacy/treatment failure, and evaluate current and future developmental challenges, so that every child has access to the resources they need to optimize their outcome and quality of life.

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Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium

Cited by 67 publications

References 91 publications

Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity

Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity

Tissue mechanics regulate brain development, homeostasis and disease

Cerebrospinal Fluid Biomarkers of Pediatric Hydrocephalus

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