Planar Microwave Sensor for Theranostic Therapy of Organic Tissue Based on Oval Split Ring Resonators

Reimann, Carolin; Puentes, Margarita; Maasch, Matthias; Hübner, Frank; Bazrafshan, Babak; Vogl, Thomas J.; Damm, Christian; Jakoby, Rolf

doi:10.3390/s16091450

Cited by 18 publications

(15 citation statements)

References 15 publications

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“…They offer files with dielectric properties for specific tissue types, where each of these files is an average dielectric model based on submitted literature data. This can improve the theoretical models and the design of sensors and/or applicators in different dielectric-based medical applications, e.g., dielectric imaging [3,4], hyperthermia [5,6], and ablation [7,8]. However, inaccuracies or errors in the submitted literature data can directly impact the sensitivity and effectiveness of these applications [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Open-Ended Coaxial Probe-to-Tissue Contact Pressure on Dielectric Measurements

Maenhout

Markovic

Ocket

et al. 2020

Sensors

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Open-ended coaxial probes are widely used to gather dielectric properties of biological tissues. Due to the lack of an agreed data acquisition protocol, several environmental conditions can cause inaccuracies when comparing dielectric data. In this work, the effect of a different measurement probe-to-tissue contact pressure was monitored in the frequency range from 0.5 to 20 GHz. Therefore, we constructed a controlled lifting platform with an integrated pressure sensor to exert a constant pressure on the tissue sample during the dielectric measurement. In the pressure range from 7.74 kPa to 77.4 kPa, we observed a linear correlation of − 0.31 ± 0.09 % and − 0.32 ± 0.14 % per kPa for, respectively, the relative real and imaginary complex permittivity. These values are statistically significant compared with the reported measurement uncertainty. Following the literature in different biology-related disciplines regarding pressure-induced variability in measurements, we hypothesize that these changes originate from squeezing out the interstitial and extracellular fluid. This process locally increases the concentration of membranes, cellular organelles, and proteins in the sensed volume. Finally, we suggest moving towards a standardized probe-to-tissue contact pressure, since the literature has already demonstrated that reprobing at the same pressure can produce repeatable data within a 1% uncertainty interval.

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Section: Introductionmentioning

confidence: 99%

Effect of Open-Ended Coaxial Probe-to-Tissue Contact Pressure on Dielectric Measurements

Maenhout

Markovic

Ocket

et al. 2020

Sensors

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“…Figure 20 shows another dual-mode applicator consisting of two oval split ring resonators (SRRs) printed on the back side of a coplanar waveguide (CPW). 75 The SRR is coupled to the CPW line and is modeled as an LC resonant circuit. Resonant frequency of the SRR is a function of its dimensions and the material it is in contact with.…”

Section: Mw Ablation Applicatorsmentioning

confidence: 99%

“…Dual-mode applicators consisting of oval SRR on the back side of a CPW. (Reprinted from Reimann et al under a Creative Commons Attribution 4.0 International license: http://creativecommons.org/licenses/by/4.0/. 75 )…”

Section: Figmentioning

confidence: 99%

“…Performance of the dual mode SRR sensor of Reimann et al 75 Shown is the frequency shift in the: (A) assessment mode, (B) simulated ablation zone, and (C-E) experimental ablation zone in liver tissue in treatment mode. (Reprinted from Reimann et al under a Creative Commons Attribution 4.0 International license: http://creativecom-mons.org/licenses/by/4.0/.…”

Section: Figmentioning

confidence: 99%

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Antenna Designs for Microwave Tissue Ablation

Fallahi

Prakash

2018

Crit Rev Biomed Eng

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Microwave (MW) ablation has emerged as a minimally invasive therapeutic modality and is in clinical use for treatment of unresectable tumors and cardiac arrhythmias, neuromodulation, endometrial ablation, and other applications. Components of image-guided MW ablation systems include high-power MW sources, ablation applicators that deliver power from the generator to the target tissue, cooling systems, energy-delivery control algorithms, and imaging guidance systems tailored to specific clinical indications. The applicator incorporates a MW antenna that radiates MW power into the surrounding tissue. A variety of antenna designs have been developed for MW ablation with the objective of efficiently transferring MW power to tissue, with a radiation pattern well matched to the size and shape of the targeted tissue. Here, we survey advances in percutaneous, endocavitary, and endoscopic antenna designs as an integral element of MW ablation applicators for a diverse set of clinical applications.

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“…Such drawbacks therefore led to the proposal of this article, whereby a planar structure with a specific topological approach is introduced. The proposed sensor is deliberately designed to be more compact, simpler, easier to fabricate, and to have a lower manufacturing cost, which makes them ideal for applications such as biosensor, chemical detection, and biochemical sensing with respect to dielectric properties measurement especially in microfluidic applications. Yet, such techniques suffer from low sensitivity and poor Q ‐factor.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic biochemical sensor based on circular SIW‐DMS approach for dielectric characterization application

Bahar

Zakaria

Arshad

et al. 2019

Int J RF Microw Comput Aided Eng

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This work proposes an advancement of microwave planar resonator sensor with high sensitivity for microfluidic dielectric characterization. The physical design was employed based on circular substrate integrated waveguide (CSIW) with an integration of defected microstrip structure (DMS). This approach can be applied to accelerate the dielectric detection, structure miniaturization and material differentiation. The presented sensor operates based on variations in the dielectric properties of solvents in the vicinity of a planar open‐ended microstrip resonator device. Further analysis in volume and concentration were performed to validate the reliability of the sensor. Validation and functionality of the sensor were investigated by experimental and results comparison. A mathematical model was developed to determine the dielectric constant and the loss tangent of the microfluidic samples. The average error detection has a lower percentage value of 0.11% by comparison to the commercial and ideal dielectric properties of the aqueous samples. The maximum relative error detection, ±0.37% implied better accuracy compared to the existing resonator sensors with more than 400 of the Q‐factor. The proposed CSIW‐DMS sensor was found to give higher accuracy and detection response; besides easier to fabricate, and compatible for integration with other electronic components in an RF sensor for variety of applications.

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Planar Microwave Sensor for Theranostic Therapy of Organic Tissue Based on Oval Split Ring Resonators

Cited by 18 publications

References 15 publications

Effect of Open-Ended Coaxial Probe-to-Tissue Contact Pressure on Dielectric Measurements

Effect of Open-Ended Coaxial Probe-to-Tissue Contact Pressure on Dielectric Measurements

Antenna Designs for Microwave Tissue Ablation

Microfluidic biochemical sensor based on circular SIW‐DMS approach for dielectric characterization application

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