Planar Hall magnetoresistive aptasensor for thrombin detection

Sinha, Brajalal; Ramulu, T.S.; Kim, K.W.; Reddy, Venu; Lee, J.J.; Kim, C.G.

doi:10.1016/j.bios.2014.03.021

Cited by 37 publications

(14 citation statements)

References 32 publications

(32 reference statements)

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“…Human α thrombin (HαT) is a biomarker for cardiovascular diseases and pulmonary metastasis. Sinha et al reported HαT detection using a planar Hall magnetoresistive (PHR) sensor [184]. They used an Au film conjugated with thiolated DNA aptamer as the sensing platform and developed a sandwich immunoassay with biotinylated aptamer in the presence of the HαT analyte.…”

Section: Applications Of Inorganic Nanomaterials In Healthcare Biomentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

161

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Section: Applications Of Inorganic Nanomaterials In Healthcare Biomentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

161

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“…Finally, a biotin-labelled secondary Apt was added to bind the thrombin-primary Apt complex and streptavidin-magnetic nanoparticles were used to measure the magnetoresistance signal. A linear response to thrombin concentration in the range of 86 pM-8.6 mM and an LOD as low as 86 pM was achieved using low sample volumes of only 2uL [61]. Interestingly, a simple Apt-target-Apt sensor was elaborated using the signal obtained after the electro-oxidation of intercalated MB and ferrocene for the quantification of thrombin.…”

Section: Cardiac Biomarkersmentioning

confidence: 99%

Immunosensors

Cristea¹,

Florea²,

Tertiş³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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Immunosensors are solid-state devices in which the immunochemical reaction is coupled to a transducer. They form one of the most important classes of affinity biosensors based on the specific recognition of antigens by antibodies to form a stable complex, in a similar way to immunoassay. Depending on the type of transducer there are four types of immunosensor: electrochemical, optical, microgravimetric and thermometric. The most commonly used bioelements for the development of electrochemical immunosensors are antibodies (Ab), followed by aptamers (Apt) and, in the last five years, microRNA (miRNA). In order to perform an early diagnosis, a method that is able to measure peptides and proteins directly in a sample, without any sample pre-treatment or any separation, is preferred. This direct detection can be performed with methods making use of the specific interaction of proteins with Ab, Apt and miRNA. The recent developments made in the immunosensor field, regarding the incorporation of nanomaterials for increased sensitivity, multiplexing or microfluidic-based devices, may have potential for promising use in industry and clinical analysis. Some examples of assays for several commercially available biomarkers will be presented. The main application fields, beside biomedical analysis, are drug abuse control, food analysis and environmental analysis.

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“…After the introduction of magnetic biosensors by Baselt et al [ 22 ] in 1998, magnetic particle based magneto-resistive sensor principles have been extended to resonance sensors [ 23 , 24 , 25 , 26 ], fluxgate sensors [ 27 , 28 ], hall effect sensors [ 29 , 30 , 31 , 32 ], magneto-resistance sensors [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ], spin valve sensors [ 40 , 41 , 42 , 43 ], and anisotropic magneto-resistance sensors [ 44 , 45 , 46 ]. However, MI effect sensors have received great attention in sensing of biological magnetic fields.…”

Section: Introductionmentioning

confidence: 99%

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Sayad

Skafidas

Kwan

2020

Sensors

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Biosensors based on magneto-impedance (MI) effect are powerful tools for biomedical applications as they are highly sensitive, stable, exhibit fast response, small in size, and have low hysteresis and power consumption. However, the performance of these biosensors is influenced by a variety of factors, including the design, geometry, materials and fabrication procedures. Other less appreciated factors influencing the MI effect include measuring circuit implementation, the material used for construction, geometry of the thin film sensing element, and patterning shapes compatible with the interface microelectronic circuitry. The type magnetic (ferrofluid, Dynabeads, and nanoparticles) and size of the particles, the magnetic particle concentration, magnetic field strength and stray magnetic fields can also affect the sensor sensitivity. Based on these considerations it is proposed that ideal MI biosensor sensitivity could be achieved when the sensor is constructed in sandwich thick magnetic layers with large sensing area in a meander shape, measured with circuitry that provides the lowest possible external inductance at high frequencies, enclosed by a protective layer between magnetic particles and sensing element, and perpendicularly magnetized when detecting high-concentration of magnetic particles.

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Planar Hall magnetoresistive aptasensor for thrombin detection

Cited by 37 publications

References 32 publications

Nanomaterials for Healthcare Biosensing Applications

Nanomaterials for Healthcare Biosensing Applications

Immunosensors

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

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