A pair of Dirac points (analogous to a vortex-antivortex pair) associated with opposite topological numbers (with ±π Berry phases) can be merged together through parameter tuning and annihilated to gap the Dirac spectrum, offering a canonical example of a topological phase transition. Here, we report transport studies on thin films of BiSbTeSe2 (BSTS), which is a 3D TI that hosts spinhelical gapless (semi-metallic) Dirac fermion surface states (SS) for sufficiently thick samples, with an observed resistivity close to h/4e 2 at the charge neutral point. When the sample thickness is reduced to ∼10 nm thick, the Dirac cones from the top and bottom surfaces can hybridize (analogous to a "merging" in the real space) and become gapped to give a trivial insulator. Furthermore, we observe that an in-plane magnetic field can drive the system again towards a metallic behavior, with a prominent negative magnetoresistance (MR, up to ∼−95%) and a temperature-insensitive resistivity close to h/2e 2 at the charge neutral point. The observation is interpreted in terms of a predicted effect of an in-plane magnetic field to reduce the hybridization gap (which, if small enough, may be smeared by disorder and a metallic behavior). A sufficiently strong magnetic field is predicted to restore and split again the Dirac points in the momentum space, inducing a distinct 2D topological semimetal (TSM) phase with 2 single-fold Dirac cones of opposite spin-momentum windings.A wide range of quantum materials including graphene, topological insulators (TIs), Dirac/Weyl semimetals, and their artificial analogues, have been identified whose low-energy excitations behave as massless Dirac particles to host novel relativistic quantum phenomena [1][2][3][4][5][6][7]. The Dirac spectra can be gapped by breaking the underlying symmetry that protects the Dirac points (DPs), or by pairwise merging and annihilation of DPs [6][7][8][9][10][11][12]. Previously predicted material platforms to explore this latter mechanism, such as graphene with engineered anisotropic nearest-neighbor hopping [9] and thin black phosphorus under a strong electric field [10], require extreme parameter tuning that is difficult to realize experimentally [11][12][13]. Alternative platforms that have enabled experimental demonstration of this effect include a microwave analogue of strained graphene [6] and cold atoms in honeycomb optical lattices [7]. On the other hand, 3D TI thin films with hybridization gapped surface states bring new opportunities to study such topological transitions in a solid-state system. In particular, merging and annihilating of top and bottom surface DPs (with opposite spin windings) can be controlled both in the real space (by sample thickness, for example demonstrated experimentally in Ref. [14] by angle-resolved photoemission spectroscopy on thin films grown by molecular beam epitaxy) and the momentum space (by an in-plane magnetic field, as theoretically proposed in Ref. [15]).In a relatively thick 3D TI film (thickness t 10 nm), the top and bott...