Plakins are involved in the maintenance of epithelial polarity
Juliana Geay,
Yoran Margaron,
David Gentien
et al.
Abstract:As epithelia are the interface between the organism and the external environment, they are often subject to damage and must be frequently renewed. However, maintaining epithelial integrity during this renewal is challenging, and loss of cell polarity is a potent inducer of tumorigenesis. In this study, we used transcriptomic data from breast cancer cells at different stages of tumor development to identify molecular changes associated with the early stages of tumor transformation. We correlated these protein e… Show more
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