Plague Vaccines: Status and Future

Sun, Wei

doi:10.1007/978-94-024-0890-4_12

Cited by 21 publications

(27 citation statements)

References 284 publications

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“…Vaccination is believed to be an efficient strategy for long-term protection. Previous reviews have comprehensively summarized different kinds of plague vaccine developments, including live recombinant, subunit, vectored, and other formulated vaccines before 2016 (see reviews 19–32 ). Here, we only update the most recent advances of vaccine development (listed in Table 1) and assess the likely prophylactic and therapeutic plague vaccines.…”

Section: Introductionmentioning

confidence: 99%

Plague vaccine: recent progress and prospects

Sun

Singh

2019

npj Vaccines

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Three great plague pandemics, resulting in nearly 200 million deaths in human history and usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human pathogens. In late 2017, a large plague outbreak raged in Madagascar attracted extensive attention and caused regional panics. The evolution of local outbreaks into a pandemic is a concern of the Centers for Disease Control and Prevention (CDC) in plague endemic regions. Until now, no licensed plague vaccine is available. Prophylactic vaccination counteracting this disease is certainly a primary choice for its long-term prevention. In this review, we summarize the latest advances in research and development of plague vaccines.

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Section: Introductionmentioning

confidence: 99%

Plague vaccine: recent progress and prospects

Sun

Singh

2019

npj Vaccines

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“…However, vaccination has played a limited role in plague control, in part because the most widely used plague vaccines are based on live Y. pestis cultures, cause adverse effects in a relatively large proportion of people vaccinated, and at best offer only 10 to 12 mo of immunity (5). While various live plague vaccines have in the past been used, or are still currently in use for routine vaccination of military personnel and some populations living in plague-endemic areas, these vaccines are contraindicated in some subpopulations (immunosuppressed and young children, for example) and revaccination must be performed to maintain immunity (30, 31). Newer molecular-component vaccines, approved for use and being tested in clinical trials (32, 33), may improve this situation, but human vaccination alone will not eliminate or even control plague in endemic areas.…”

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confidence: 99%

Living with plague: Lessons from the Soviet Union’s antiplague system

Jones

Atshabar

Schmid

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Zoonoses, such as plague, are primarily animal diseases that spill over into human populations. While the goal of eradicating such diseases is enticing, historical experience validates abandoning eradication in favor of ecologically based control strategies (which reduce morbidity and mortality to a locally accepted risk level). During the 20th century, one of the most extensive plague-eradication efforts in recorded history was undertaken to enable large-scale changes in land use in the former Soviet Union (including vast areas of central Asia). Despite expending tremendous resources in its attempt to eradicate plague, the Soviet antiplague response gradually abandoned the goal of eradication in favor of plague control linked with developing basic knowledge of plague ecology. Drawing from this experience, we combine new gray-literature sources, historical and recent research, and fieldwork to outline best practices for the control of spillover from zoonoses while minimally disrupting wildlife ecosystems, and we briefly compare the Soviet case with that of endemic plague in the western United States. We argue for the allocation of sufficient resources to maintain ongoing local surveillance, education, and targeted control measures; to incorporate novel technologies selectively; and to use ecological research to inform developing landscape-based models for transmission interruption. We conclude that living with emergent and reemergent zoonotic diseases—switching to control—opens wider possibilities for interrupting spillover while preserving natural ecosystems, encouraging adaptation to local conditions, and using technological tools judiciously and in a cost-effective way.

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“…According to the opinion of a number of researchers dealing with the problems of the vaccine-based prevention of plague [ 82 , 151 ], it is not realistic to create a molecular or particle vaccine equal in effectivity to the live plague vaccine. It is likely that the lower intensity of immunity induced by subunit or particle vaccines will be quite sufficient to ensure the effectiveness of anti-epidemic measures, given the known main advantages of such treatments: (i) the possibility of combined use with antibiotics and (ii) a high speed of immunity formation.…”

Section: Directions For Future Researchmentioning

confidence: 99%

Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague

et al. 2020

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Despite the relatively low incidence of plague, its etiological agent, Yersinia pestis, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant Y. pestis strains indicate the advisability of using asymmetric responses, such as phage therapy and vaccine prophylaxis in the fight against this problem. The current relatively effective live plague vaccine is not approved for use in most countries because of its ability to cause heavy local and system reactions and even a generalized infectious process in people with a repressed immune status or metabolic disorders, as well as lethal infection in some species of nonhuman primates. Therefore, developing alternative vaccines is of high priority and importance. However, until now, work on the development of plague vaccines has mainly focused on screening for the potential immunogens. Several investigators have identified the protective potency of bacterial outer membrane vesicles (OMVs) as a promising basis for bacterial vaccine candidates. This review is aimed at presenting these candidates of plague vaccine and the results of their analysis in animal models.

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Plague Vaccines: Status and Future

Cited by 21 publications

References 284 publications

Plague vaccine: recent progress and prospects

Plague vaccine: recent progress and prospects

Living with plague: Lessons from the Soviet Union’s antiplague system

Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague

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