Plague-Positive Mouse Fleas on Mice Before Plague Induced Die-Offs in Black-Tailed and White-Tailed Prairie Dogs

Bron, Gebbiena M.; Malave, Carly; Boulerice, Jesse T.; Osorio, Jorge E.; Rocke, Tonie E.

doi:10.1089/vbz.2018.2322

Cited by 5 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detection indicates presence, and presumably challenge to animals, but absence of detection does not mean absence of the pathogen or absence of challenge. The rarity of Y. pestis detections given our nontrivial sampling efforts, along with the rarity of Y. pestis detections from Holmes et al ( 2006 ), Biggins et al ( 2010 ), Matchett et al ( 2010 ), Russell et al ( 2018 ), and Bron et al ( 2019 ), are among the reasons we did not include a plague detection variable in our evaluations (for additional discussion, see Eads and Biggins 2021 , Eads et al 2021 ).…”

Section: Discussionmentioning

confidence: 96%

“…Enzootic plague, as defined by Biggins and Eads ( 2019 ), likely circulates frequently in plague endemic areas, including our study area in Montana (Hanson et al 2007 , Matchett et al 2010 ). Hanson et al ( 2007 ), Griffin et al ( 2010 ), Matchett et al ( 2010 ), St. Romain et al (2013), Bron et al ( 2019 ), and Liccioli et al ( 2020 ), all reported detecting Y. pestis in fleas or carcasses from PD colonies that were not currently experiencing an epizootic. Near our study area, BFF that were vaccinated against plague and residing on areas without flea control had 266% higher annual reencounter rates compared with nonvaccinates during a time when black-tailed PD ( C. ludovicianus , BTPD) populations appeared healthy and stable (Matchett et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Cynomys spp.) for Endangered Black-Footed Ferret (Mustela nigripes) Conservation

Matchett

Stanley

McCollister

et al. 2021

Vector-Borne and Zoonotic Diseases

Self Cite

View full text Add to dashboard Cite

The plague bacterium Yersinia pestis is lethal to endangered black-footed ferrets ( Mustela nigripes , BFF) and the prairie dogs ( Cynomys spp., PD) on which they depend for habitat and prey. We assessed the effectiveness of an oral sylvatic plague vaccine delivered in baits to black-tailed PD ( Cynomys ludovicianus , BTPD) from 2013 to 2017 on the Charles M. Russell National Wildlife Refuge (CMR) in northcentral Montana. We permanently marked BTPD on four paired vaccine ( N = 1,349 individuals) and placebo plots ( N = 926; 7,027 total captures). We analyzed capture–recapture data under a Cormack–Jolly–Seber model to estimate annual apparent survival. Overall, survival averaged 0.05 lower on vaccine plots than on paired placebo plots. Immediately before noticeable die-offs and detecting plague on pairs CMR1 and CMR2, 89% of BTPD sampled on vaccine plots had consumed at least one bait and the immune systems of 40% were likely boosted by consuming baits over multiple years. Survival to the following year was 0.16 and 0.05 on the vaccine plots and 0.19 and 0.06 on the placebo plots for pairs CMR1 and CMR2, respectively. These rates were markedly lower than 0.63, the overall average estimate on those same plots during the previous 3 years. PD populations subjected to such large die-offs would not be expected to sustain a BFF population. An overriding limitation to achieving sufficient protection rests with vaccine delivery constraints. Late summer/fall bait distribution results in the highest bait uptake rates. However, the PD birth pulse each spring can double the size of populations in most years, greatly reducing the proportion of vaccinates in populations and diminishing potential herd immunity benefits. In addition to nonvaccinated juveniles and PD that do not consume bait, incomplete vaccine protection and time required for immunity to develop leaves a large majority of PD populations vulnerable to plague for 6–7 months or more each year.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Cynomys spp.) for Endangered Black-Footed Ferret (Mustela nigripes) Conservation

Matchett

Stanley

McCollister

et al. 2021

Vector-Borne and Zoonotic Diseases

Self Cite

View full text Add to dashboard Cite

show abstract

“… 2010 ; Bron et al . 2019 ), or no Y. pestis positive fleas at all if plague outbreaks did not occur during any years of the study (Holmes et al . 2006 ); but also see Romain et al .…”

Section: Discussionmentioning

confidence: 99%

“… 2017 ; Bron et al . 2019 ; Bai et al . 2020 ), mouse inoculation, genotyping of Y. pestis present in infected fleas (Girard et al .…”

Section: Discussionmentioning

confidence: 99%

No evidence for enzootic plague within black‐tailed prairie dog (Cynomys ludovicianus) populations

et al. 2021

View full text Add to dashboard Cite

Yersinia pestis, causative agent of plague, occurs throughout the western United States in rodent populations and periodically causes epizootics in susceptible species, including black‐tailed prairie dogs (Cynomys ludovicianus). How Y. pestis persists long‐term in the environment between these epizootics is poorly understood but multiple mechanisms have been proposed, including, among others, a separate enzootic transmission cycle that maintains Y. pestis without involvement of epizootic hosts and persistence of Y. pestis within epizootic host populations without causing high mortality within those populations. We live‐trapped and collected fleas from black‐tailed prairie dogs and other mammal species from sites with and without black‐tailed prairie dogs in 2004 and 2005 and tested all fleas for presence of Y. pestis. Y. pestis was not detected in 2126 fleas collected in 2004 but was detected in 294 fleas collected from multiple sites in 2005, before and during a widespread epizootic that drastically reduced black‐tailed prairie dog populations in the affected colonies. Temporal and spatial patterns of Y. pestis occurrence in fleas and genotyping of Y. pestis present in some infected fleas suggest Y. pestis was introduced multiple times from sources outside the study area and once introduced, was dispersed between several sites. We conclude Y. pestis likely was not present in these black‐tailed prairie dog colonies prior to epizootic activity in these colonies. Although we did not identify likely enzootic hosts, we found evidence that deer mice (Peromyscus maniculatus) may serve as bridging hosts for Y. pestis between unknown enzootic hosts and black‐tailed prairie dogs.

show abstract

“…North American deer mice ( Peromyscus maniculatus ) and closely related rodents of the Cricetidae family carry 18 of the 20 critical residues within the ACE-2 receptor, facilitating SARS-CoV-2 spike protein binding [ 194 ]. As the most studied and abundant mammal species in North America, [ 195 ], deer mice are known reservoirs for other zoonotic pathogens including Borrelia burgodferi (Lyme disease), Yersinia pestis (plague), and Sin Nombre orthohantavirus (hantavirus pulmonary syndrome) [ 196 , 197 ] that could spill over into human populations. Experimental inoculations demonstrated that deer mice are susceptible to SARS-CoV-2 without showing clinical signs of infection, and can spread SARS-CoV-2 to uninoculated susceptible mice [ 194 ].…”

Section: Animal Host Diversity Of Sars-cov-2mentioning

confidence: 99%

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

Hedman¹,

Krawczyk

Helmy

et al. 2021

Pathogens

View full text Add to dashboard Cite

Emerging infectious diseases present great risks to public health. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become an urgent public health issue of global concern. It is speculated that the virus first emerged through a zoonotic spillover. Basic research studies have suggested that bats are likely the ancestral reservoir host. Nonetheless, the evolutionary history and host susceptibility of SARS-CoV-2 remains unclear as a multitude of animals has been proposed as potential intermediate or dead-end hosts. SARS-CoV-2 has been isolated from domestic animals, both companion and livestock, as well as in captive wildlife that were in close contact with human COVID-19 cases. Currently, domestic mink is the only known animal that is susceptible to a natural infection, develop severe illness, and can also transmit SARS-CoV-2 to other minks and humans. To improve foundational knowledge of SARS-CoV-2, we are conducting a synthesis review of its host diversity and transmission pathways. To mitigate this COVID-19 pandemic, we strongly advocate for a systems-oriented scientific approach that comprehensively evaluates the transmission of SARS-CoV-2 at the human and animal interface.

show abstract

Plague-Positive Mouse Fleas on Mice Before Plague Induced Die-Offs in Black-Tailed and White-Tailed Prairie Dogs

Cited by 5 publications

References 35 publications

Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Cynomys spp.) for Endangered Black-Footed Ferret (Mustela nigripes) Conservation

Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Cynomys spp.) for Endangered Black-Footed Ferret (Mustela nigripes) Conservation

No evidence for enzootic plague within black‐tailed prairie dog (Cynomys ludovicianus) populations

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

Contact Info

Product

Resources

About