Placentation in the degu (Octodon degus): Analogies with extrasubplacental trophoblast and human extravillous trophoblast

Bosco, Cleofina; Buffet, Chosica; Bello, Mónica; Rodrigo, Ramón; Gutiérrez, M. E.; García, Gernika

doi:10.1016/j.cbpa.2005.12.013

Cited by 28 publications

(43 citation statements)

References 45 publications

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“…This would give a stronger support to our proposal of the degu as an experimental animal model for the study of preeclampsia in the early stages of placentation [10,16].…”

Section: Discussionsupporting

confidence: 57%

“…This is the first time that the occurrence of an ectopic pregnancy in the degu is reported, although a direct placental attachment to the maternal viscera was not observed, probably due to scarse development of the subplacenta (cytotrophoblast) which disappear when it differentiates into syncytiotrophoblast [10]. Clinically, there were no pathognomonic signs or symptoms of the presence of these masses in the peritoneal cavity and the animal death was probably the result of compression of surrounding structures such as heart and lungs.…”

Section: Discussionmentioning

confidence: 74%

“…The core contained the fetal placental capillaries (Figures 5(b) and 5(d)) [8]. It must be emphasized that, in the degu's placental barrier, the fetal capillaries are separated from the maternal blood by a single layer of labyrinthine fine syncytium, derived from the cytotrophoblast of the subplacenta [9,10]. In addition, a structure resembling an umbilical cord was observed inserted into the bigger mass (Figure 3(d)).…”

Section: Resultsmentioning

confidence: 99%

“…It is important to note that the placenta of the degu is hemomonochorial and labyrinthine as in the guinea pig [9,15] and that the degus cytotrophoblast develops from the subplacenta, from which the syncytial labyrinthine placental barrier is formed [10,16]. On the other hand, Bland and Donovan [17] were able to induce abdominal implantation in guinea pig by introducing fertilized eggs into the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

“…In a histological micrograph, these authors showed a subplacenta and invasive trophoblast in the spleen but not the development of a real placental organ as we report in the present study. In addition, Bosco et al [10,16] demonstrated that in the degu the cytotrophoblast is found only in the subplacenta and not in the labyrinthine placental barrier as it is known to occur in the human villous placental barrier. In the human species, each villus consists of a central core of loose connective tissue surrounded by a double layer of trophoblast, an outer syncytiotrophoblast and an inner cytotrophoblast that differentiate to syncytiotrophoblast [8], as is the case in this report (see Figures 5(a), 5(b), 5(c), and 5(d)).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a Cytotrophoblast That Mimics Human Chorionic Placenta

Bosco

Díaz

González

et al. 2014

Case Reports in Veterinary Medicine

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This report describes a case of abdominal pregnancy in an adult female degu from which we recovered two large tissular masses from the peritoneal cavity. The bigger one showed a number of thin vascular connections to the serosa layer of the small intestine. It was also directly connected to the smaller mass by a thin membranous process. The surface of the bigger mass facing the small intestine wall showed the presence of chorionic villous that resembled a villous human chorionic placenta, rather than the hemomonochorial labyrinthine placenta, characteristic of this species. This unusual finding leads us to postulate that in the degu's uterus the cytotrophoblast is exposed to a number of factors that will activate cascades of cellular and molecular events that ultimately will be signaling the cytotrophoblast to develop into a labyrinthine hemomonochorial placenta. In absence of the proper uterine environment, as is the case of the abdominal pregnancy in the peritoneal cavity reported here, the lack of signaling will lead the cytotrophoblast to develop into a villous chorionic placenta, similar to that observed in human.

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“…This would give a stronger support to our proposal of the degu as an experimental animal model for the study of preeclampsia in the early stages of placentation [10,16].…”

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a Cytotrophoblast That Mimics Human Chorionic Placenta

Bosco

Díaz

González

et al. 2014

Case Reports in Veterinary Medicine

View full text Add to dashboard Cite

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The subplacenta in Octodon degus and petromus typicus—two hystricognath rodents without significant placental lobulation

Mess

2006

J Exp Zool Pt B

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Until now, defining characters of hystricognath rodents have been the subplacenta and the lobulation of the main chorioallantoic placenta. However, recent studies have revealed hystricognaths without marked lobulation, which is a plesiomorphic condition of the group. The question thus arises whether the subplacenta of these taxa is structurally homologous to that of other hystricognaths. Therefore, subplacental morphology and ontogeny were investigated in Octodon and Petromus by conventional light and electron microscopy, and the stem species pattern of Hystricognathi was reconstructed by applying MacClade. The subplacentae of both species share important similarities with other hystricognaths. The organ develops early in gestation but degenerates towards term. It consists of folded layers of cellular and syncytial trophoblast, the latter enclosing maternal blood lacunae and electron-dense particles. Root-like syncytial outgrowths (syncytial streamers) and extraplacental trophoblast cells occur at the lateral and basal borders of the organ. Maternal vascularisation by blood lacunae within the subplacental syncytiotrophoblast is acquired early but lost during mid-gestation. Vascularisation by fetal vessels is established later. Fetomaternal exchange via blood circulation inside the subplacenta is unlikely to occur, since periods of maternal and fetal vascularisation show little overlap. In conclusion, the subplacentae of both species are regarded as homologous to other hystricognaths, comprising 18 character conditions that belong to their stem species pattern. Thus, the systematic unity of the group can be confirmed.

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Development of the chorioallantoic placenta in Octodon degus—a model for growth processes in caviomorph rodents?

Mess

2007

J Exp Zool Pt B

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The degu Octodon degus is one of the very few members of caviomorph or hystricognath Rodentia that possesses a simply arranged chorioallantoic placenta without advanced lobulation. Therefore this species was used as a model to study regional development and growth processes of the placenta, based on the examination of 20 individuals by light and electron microscopy as well as by using markers for proliferation, trophoblast and endometrial stroma. The results were interpreted by comparison with other hystricognaths in the light of their evolutionary history. It was found that trophoblast derived from the trophospongium is essential for extension of the placenta including the labyrinth: extensive proliferation is restricted to trophoblast cells at the outer margin of the placenta and along internally directed, finger-tip like protrusions of fetal mesenchyme towards the labyrinth. This kind of placental development is regarded as part of the stem species pattern of hystricognaths, evolved more than 40 million years ago. It is indicated for the first time that the replenishment of the syncytiotrophoblast is similar to corresponding processes in the human placenta. In conclusion, the degu is a useful model for placental growth dynamics, particularly because of its simply arranged placental architecture, and may also serve as an animal model in comparison to human pregnancies.

show abstract

Placentation in the degu (Octodon degus): Analogies with extrasubplacental trophoblast and human extravillous trophoblast

Cited by 28 publications

References 45 publications

Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a Cytotrophoblast That Mimics Human Chorionic Placenta

Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a Cytotrophoblast That Mimics Human Chorionic Placenta

The subplacenta in Octodon degus and petromus typicus—two hystricognath rodents without significant placental lobulation

Development of the chorioallantoic placenta in Octodon degus—a model for growth processes in caviomorph rodents?

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