Placental transfer of immunoglobulin G subclasses

Abstract

The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B.

Age‐specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite™ automated turbidimetric analyzer

“…40 IgG2 antibody concentrations are less affected by maternal transfer of IgG (compared to IgG1), as transfer of this subclass is the least efficient of the four IgG subclasses. [41][42][43] The transient delay in IgG2 antibody production is clinically relevant in the context of vaccination, as this subclass is mainly responsible for the response to polysaccharide antigens. 44,45 where the predominant response is mediated by IgG1.…”

Placental Transfer of a Fully Human IgG2 Monoclonal Antibody in the Cynomolgus Monkey, Rat, and Rabbit: A Comparative Assessment from during Organogenesis to Late Gestation

“…During the first trimester of human pregnancy, coelomic fluid composition is proposed to approximate embryo-fetal serum (Jauniaux et al, 1995). Differences in transfer in humans have also been observed between IgG isotypes, with IgG1 being transferred more efficiently than IgG2 antibodies (Garty et al, 1994;Englund et al, 1995;Malek et al, 1996;de Voer et al, 2009;Palmeira et al, 2009).…”

Biodistribution and toxicity of epitope‐functionalized dextran iron oxide nanoparticles in a pregnant murine model

“…their dominant epitopic regions (Braunschweig et al, 2013). During gestation, maternal immunoglobulin G (IgG) antibodies cross the placenta into the fetal compartments to provide the IgG-naïve fetus with passive immunity (Garty, Ludomirsky, Danon, Peter, & Douglas, 1994).…”