Placental Transfer of Hepatitis a Antibodies in Full Term and Preterm Infants

Linder, Nehama; Karetnyi, Yuori; Gidony, Yariv; Ohel, Gonen; Sapir, Einav; J, Kuint; Davidovich, Nadav; Gidony, Ifat; Mendelson, Ella; Barzilai, Asher

doi:10.1097/00006454-199702000-00015

Cited by 10 publications

(3 citation statements)

References 5 publications

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“…28 Anti-HAV levels at 2 months of age from passively acquired maternal antibody are substantially higher than those observed after IG administration and would be expected to have a similar or greater effect on the response to vaccine. 29 All vaccinated infants of anti-HAV-positive mothers had protective levels of anti-HAV at 15 months of age that were lower than levels of infants born to anti-HAV-negative mothers. However, the clinical implications of these lower anti-HAV levels are unclear.…”

Section: Discussionmentioning

confidence: 89%

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Letson¹,

Shapiro²,

Kuehn³

et al. 2004

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 89%

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Letson¹,

Shapiro²,

Kuehn³

et al. 2004

The Journal of Pediatrics

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“…Various data suggest that the influence of gestational age on the efficiency of antibody transport may vary according to the antigen tested and to the characteristics of the antibody against a given antigen. In this regard, viral antibody concentrations in preterm infants are lower than [Linder et al, 1998;Gonçalves et al, 1999;Ozbek et al, 1999] or similar to [Linder et al, 1997;Wesumperuma et al, 1999] those in term infants.…”

Section: Introductionmentioning

confidence: 93%

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Mussi-Pinhata¹,

Pinto²,

Yamamoto³

et al. 2002

Journal of Medical Virology

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Maternal antibodies may protect the fetus and neonate against severe forms of CMV-caused disease, therefore this study investigated the efficiency of the placental transfer of naturally acquired, maternal total anti-cytomegalovirus (CMV) IgG and neutralizing antibodies at different gestational ages. The study was conducted on 182 healthy CMV-seropositive Brazilian mothers and their 196 infants who were not infected congenitally with CMV, as determined by CMV detection in urine. The study groups were composed of 44 infants aged 28-30 weeks; 51 infants aged 31-33 weeks; 62 infants aged 34-36 weeks, and 39 infants of gestational age > or = 37 weeks. Quantitative detection of total CMV IgG was carried out using EIA and virus neutralizing titers were determined by a microneutralization assay in sera from mothers and infants. CMV IgG levels and neutralizing titers of the infants correlated with maternal levels (r=0.873 and r=0.841, respectively). The efficiency of placental transfer of these antibodies was enhanced significantly as gestation progressed until 34-36 weeks, when values similar to those of full-term infants (90-100%) were found. Transfer ratios were significantly higher for neutralizing compared to total CMV IgG antibodies at gestational age 31-33 weeks (100% vs. 84%, respectively) and at gestational age 28-30 weeks (75% vs. 60%, respectively). We conclude that placental transfer of naturally acquired maternal CMV neutralizing and total CMV IgG antibodies are similarly efficient above 34 weeks of gestational age. At less than 34 weeks of gestational age, transfer of neutralizing antibodies may be favored and these antibodies reach the neonatal serum of 99% of these premature infants.

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“…The seroprevalence in all three populations increased in relation to the age of the subjects and reached its peak with the Thai people residing in the border area who, on average, were older than Myanmar immigrant workers but younger than positive subjects within the general Thai population. As it has been previously shown that HAV IgG antibodies can be trans-placentally transferred (8), the spike of seroprevalence in infancy merely reflected the seroprevalence of HAV infection among women of childbearing age which was almost equivalent to the overall seroprevalence among this population.…”

Section: Discussionmentioning

confidence: 84%

Seroprevalence of Hepatitis A among Thai Population Residing Near Myanmar Border

Rianthavorn

Fakthongyoo²,

Yamsut³

et al. 2011

J Health Popul Nutr

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When compared with Thailand, the seroprevalence of hepatitis A virus (HAV) is extremely high among its neighbouring countries. To investigate the seroprevalence of HAV among the Thai people residing in the border area between Thailand and Myanmar, 308 residents in Umphang, Maesod district, Tak, were recruited. Sera were tested for HAV IgG antibodies by enzyme-linked immunosorbent assay. The overall seroprevalence among the Thai people residing in the border area of Thailand was significantly higher than that among the general Thai population (71% vs 27% respectively, p<0.05). As asymptomatic or mild HAV infection typically occurs in children, the Thai people residing in the border area may receive little benefit from universal HAV vaccination. Lower protective antibodies against HAV, along with the exclusion of HAV vaccine from the Expanded Programme on Immunization, potentially increase the susceptibility to HAV among the general Thai population and may lead to more future outbreaks if HAV is introduced from the border areas. The findings suggest that HAV vaccines should be recommended to travellers before their journey to the border between Thailand and Myanmar where HAV is endemic.

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Placental Transfer of Hepatitis a Antibodies in Full Term and Preterm Infants

Cited by 10 publications

References 5 publications

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Seroprevalence of Hepatitis A among Thai Population Residing Near Myanmar Border

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