Placental transfer of and infantile exposure to perchlorate

Zhang, Tao; Ma, Yufang; Wang, Dou; Li, Rudan; Chen, Xiaojia; Weiwen, Mo,; Qin, Xiaolei; Sun, Hongwen; Kannan, Kurunthachalam

doi:10.1016/j.chemosphere.2015.09.073

Cited by 32 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blount et al specifically analyzed the perinatal exposure to goitrogen chemicals in 150 mothers from New Jersey (USA), showing that the placental barrier was more permeable to I respective to goitrogens and maternal urinary ClO 4 − concentrations were directly correlated with ClO 4 − concentration in amniotic fluid, thus resulting an useful tool for assessing fetal exposure [ 91 ]. As observed in a Chinese population, ClO 4 − was detected in infant’s urine (22.4 ng/mL) and cord blood serum (3.2 ng/mL) at a concentration about 22 times greater compared to that reported by Blount (0.14 µg/L) [ 92 ]. This finding is difficult to explain, but could be attributable to different environmental exposures or dissimilarities in assay or both.…”

Section: Resultsmentioning

confidence: 76%

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

et al. 2020

View full text Add to dashboard Cite

Background: Perchlorate-induced natrium-iodide symporter (NIS) interference is a well-recognized thyroid disrupting mechanism. It is unclear, however, whether a chronic low-dose exposure to perchlorate delivered by food and drinks may cause thyroid dysfunction in the long term. Thus, the aim of this review was to overview and summarize literature results in order to clarify this issue. Methods: Authors searched PubMed/MEDLINE, Scopus, Web of Science, institutional websites and Google until April 2020 for relevant information about the fundamental mechanism of the thyroid NIS interference induced by orally consumed perchlorate compounds and its clinical consequences. Results: Food and drinking water should be considered relevant sources of perchlorate. Despite some controversies, cross-sectional studies demonstrated that perchlorate exposure affects thyroid hormone synthesis in infants, adolescents and adults, particularly in the case of underlying thyroid diseases and iodine insufficiency. An exaggerated exposure to perchlorate during pregnancy leads to a worse neurocognitive and behavioral development outcome in infants, regardless of maternal thyroid hormone levels. Discussion and conclusion: The effects of a chronic low-dose perchlorate exposure on thyroid homeostasis remain still unclear, leading to concerns especially for highly sensitive patients. Specific studies are needed to clarify this issue, aiming to better define strategies of detection and prevention.

show abstract

Section: Resultsmentioning

confidence: 76%

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The median DI breast of ∑NEOs (45.3 ng/kg bw/d) was higher than the median DI formula‑MW (36.5 ng/kg bw/d), which indicates that breast-fed infants tend to have higher exposure to NEOs (Figure ). Previous studies have also reported higher exposure to polybrominated biphenyl ethers, organochlorine compounds, and perchlorate among breast-fed infants than in formula-fed infants. However, the dissolved infant formula samples contained higher median concentrations of ACE and THD relative to breast milk, and the DI formula‑MW values for these NEOs were higher than the DI breast values (Figure ).…”

Section: Resultsmentioning

confidence: 81%

Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources

Zhang

Wang

Zhu

et al. 2023

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Little is known about exposure of infants to neonicotinoid insecticides (NEOs). In this study, concentrations of six parent NEOs (p-NEOs) and N-desmethyl-acetamiprid (N-dm-ACE) were measured in urine and whole blood samples from infants, in addition to breast milk, infant formula, and tap water collected in South China. The p-NEO with the highest median concentration in urine (0.25 ng/mL) and blood (1.30) samples was dinotefuran (DIN), while imidacloprid (IMI) was abundant in breast milk (median: 0.27 ng/mL), infant formula (0.22), and tap water (0.028). The older infants (181–360 days) might face higher NEO and N-dm-ACE exposure than younger infants (0–180 days). Blood samples contained a significantly (p < 0.01) higher median concentration of ∑6 p-NEOs (2.03 ng/mL) than that of urine samples (0.41), similar to acetamiprid (ACE), IMI, thiacloprid (THD), DIN, and N-dm-ACE, suggesting that NEOs readily partition into blood. Furthermore, breast-fed infants tend to have higher exposure levels than formula-fed infants. Infant formula prepared with tap water augmented the daily intake of ∑NEOs. The external sources contributed 80% of the total dose to IMI and clothianidin (CLO) exposure, while other unknown sources contributed to ACE, THD, and DIN exposure in infants. To the best of our knowledge, this is the first study to assess levels and sources of infantile exposure to NEOs through internal and external exposure assessment.

show abstract

“…It inhibits iodine fixation, a process necessary for the production of thyroid hormones, leading to hypothyroidism (Ghosh et al 2014;Murray and Bolger 2014;Cao et al 2019). The thyroid gland, considered a major target for perchlorate, plays an important role in the regulation of metabolism and is essential for normal growth and development in children (Bruce et al 1999; Agency for Toxic Substances and Disease Registry 2008; Bardiya and Bae 2011;Murray and Bolger 2014;Zhang et al 2016).…”

Section: Health Effects On Humansmentioning

confidence: 99%

Perchlorate Contamination: Sources, Effects, and Technologies for Remediation

Acevedo-Barrios

Olívero-Verbel

2021

Reviews of Environmental Contamination and Toxicology

View full text Add to dashboard Cite

Perchlorate is a persistent pollutant, generated via natural and anthropogenic processes, that possesses a high potential for endocrine disruption in humans and biota. It inhibits iodine fixation, a major reason for eliminating this pollutant from ecosystems. Remediation of perchlorate can be achieved with various physicochemical treatments, especially at low concentrations. However, microbiological approaches using microorganisms, such as those from the genera Dechloromonas, Serratia, Propionivibrio, Wolinella, and Azospirillum, are promising when perchlorate pollution is extensive. Perchlorate-reducing bacteria, isolated from harsh

show abstract

Placental transfer of and infantile exposure to perchlorate

Cited by 32 publications

References 47 publications

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources

Perchlorate Contamination: Sources, Effects, and Technologies for Remediation

Contact Info

Product

Resources

About