Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusion

Karttunen, Vesa; Myllynen, Päivi; Prochazka, Gabriela; Pelkonen, Olavi; Segerbäck, Dan; Vähäkangas, Kirsi

doi:10.1016/j.toxlet.2010.04.028

Cited by 62 publications

(31 citation statements)

References 49 publications

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“…Evidence is emerging that nicotine can damage the genome, disrupt cellular metabolic processes, amplify oncogenes, inactivate tumor suppressor genes, and in this way promote a cancer-supporting environment [10]. The carcinogenic polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene in cigarette smoke has been shown to cross human placental barrier [103]. Evidence from animal studies supports the increased cancer risk by PAHs observed in epidemiological studies [4].…”

Section: Discussionmentioning

confidence: 99%

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

et al. 2016

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BackgroundIn spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases.ObjectivesThe aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the associated early life cancer types, and to quantify the associations.MethodsIn a systematic literature search 825 articles were identified in PubMed and Web of Science, and 55 more through the reference lists. Of these 62 fulfilled the criteria for inclusion in meta-analyses. Using Mantel-Haenszel or DerSimonian and Laird method, depending on heterogeneity of the studies, pooled estimates and 95% confidence intervals for eight cancer types were calculated.ResultsSmoking during pregnancy was associated with an increased risk for for brain and central nervous system tumors (OR = 1.09; 95% CI = 1.02–1.17). Although the risk for lymphoma was also associated (OR = 1.21; 95% CI = 1.05–1.34), it did not hold up in subgroup analyses. Leukemia was not found to be associated with maternal smoking. Five other cancer types (bone, soft tissue, renal, hepatic, and germ cell cancer) were also examined, but the number of studies was too limited to exclude the possibility of maternal smoking as a risk factor for cancer in offspring.ConclusionsAccording to our meta-analyses, maternal smoking is associated with nervous system cancers, but not with leukemia in early life. Confirming or rejecting associations of maternal smoking with lymphoma and the five other cancer types requires further studies.

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Section: Discussionmentioning

confidence: 99%

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

et al. 2016

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“…Many of these substances, such as polycyclic aromatic hydrocarbons, readily pass through the placental barrier into the foetal compartment [2]. Maternal smoking increases the risk of miscarriage, ectopic pregnancy, placenta praevia and foetal orofacial clefts in early pregnancy and foetal growth restriction, placental insufficiency, placental abruption, premature rupture of placental membranes and preterm delivery in late pregnancy [3], [4].…”

Section: Introductionmentioning

confidence: 99%

The human placental proteome is affected by maternal smoking

Huuskonen

Amezaga

Bellingham

et al. 2016

Reproductive Toxicology

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“…In ovarian tissue, BPDE-DNA adducts were detected in oocytes and luteal cells in ovaries of adult women who were exposed to cigarette smoke from smoking themselves or from secondhand smoke (Wright et al, 2006). B[a]P was reported to cross the placenta in mice, rats, and guinea pigs following maternal injection, dermal, or inhalation exposure to B[a]P (Karttunena et al, 2010). Evidence from human studies indicates that BPDE-DNA adducts have been found in the placentas of smoking mothers (Motejlek et al, 2006).…”

Section: Benzo[a]pyrene and Female Fertilitymentioning

confidence: 99%

Benzo[a]pyrene and Human Embryo

Shi¹,

Liu²,

Ye³

2012

The Human Embryo

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Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusion

Cited by 62 publications

References 49 publications

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

The human placental proteome is affected by maternal smoking

Benzo[a]pyrene and Human Embryo

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